Research Appraisals
Evidence-based critical appraisals of the latest medical research, systematically evaluated using Oxford CEBM methodology.
Showing 63 appraisals
Bulletin of the World Health Organization
Digital epidemiology investments, Saudi Arabia
PROBLEM: Traditional epidemiological surveillance methods are often limited by delays in reporting and fragmented data systems. Saudi Arabia faces additional public health challenges from mass gatherings during Hajj and Umrah, an increasing burden of noncommunicable diseases and rapid urbanization, highlighting the need for investing in digital epidemiology. APPROACH: Saudi Arabia has accelerated digital transformation in health care through Vision 2030 initiatives. The strategies include health information exchange platforms, analytics driven by artificial intelligence, telemedicine services and digital monitoring systems used during Hajj. We review current initiatives to invest in digital epidemiology in Saudi Arabia, implementation challenges and policy priorities. LOCAL SETTING: Saudi Arabia's health system operates under a predominantly public model. The health ministry is the main provider, regulator and finance provider of most health-care services. Health-care coverage is nearly universal, with citizens receiving services free of charge through the public system. Ongoing reforms aim to gradually decentralize certain functions. RELEVANT CHANGES: The initiatives under Vision 2030 have supported disease surveillance, data integration and public health response capacities. Existing digital health reforms have created a foundation for integrating digital epidemiology into routine public health practice. However, challenges remain, including fragmented interoperability between institutions, workforce shortages, unequal digital access, and concerns about data governance, privacy and algorithmic bias. LESSONS LEARNT: Saudi Arabia's experience suggests that digital epidemiology is more effective when integrated within broader digital health reforms. Successful implementation requires not only digital infrastructure, but also workforce development, ethical governance, transparency and mechanisms for integrating digital data into public health decision-making. PROBLÈME: Les méthodes traditionnelles de surveillance épidémiologique sont souvent limitées par des retards dans la transmission des données et par la fragmentation des systèmes de données. L’Arabie saoudite est confrontée à des défis supplémentaires en matière de santé publique liés aux rassemblements de masse lors du Hajj et de la Omra, au fardeau croissant des maladies non transmissibles et à l’urbanisation rapide, ce qui souligne la nécessité d’investir dans l’épidémiologie numérique. APPROCHE: L’Arabie saoudite a accéléré la transformation numérique dans le domaine des soins de santé grâce aux initiatives de la Vision 2030. Ces stratégies comprennent des plateformes d’échange d’informations de santé, des analyses alimentées par l’intelligence artificielle, des services de télémédecine et des systèmes de surveillance numérique employés pendant le Hajj. La présente étude passe en revue les initiatives actuelles visant à investir dans l’épidémiologie numérique en Arabie saoudite, les défis liés à leur mise en œuvre et les priorités politiques. ENVIRONNEMENT LOCAL: Le système de santé saoudien fonctionne selon un modèle majoritairement public. Le ministère de la Santé est le principal prestataire, régulateur et bailleur de fonds de la plupart des services de santé. La couverture des soins de santé est pratiquement universelle, les citoyens bénéficiant de services gratuits au travers du système public. Les réformes en cours visent à décentraliser progressivement certaines fonctions. CHANGEMENTS SIGNIFICATIFS: Les initiatives menées dans le cadre de la Vision 2030 ont favorisé la surveillance des maladies, l’intégration des données et le renforcement des capacités d’intervention de santé publique. Les réformes existantes en matière de santé numérique ont jeté les bases nécessaires à l’intégration de l’épidémiologie numérique dans les pratiques courantes de santé publique. Toutefois, des défis subsistent, notamment le manque d’interopérabilité entre les établissements, la pénurie de main-d’œuvre, les inégalités d’accès au numérique, ainsi que des préoccupations en matière de gouvernance des données, de confidentialité et de biais dû aux algorithmes. LEÇONS TIRÉES: L’expérience de l’Arabie saoudite suggère une plus grande efficacité de l’épidémiologie numérique lorsque celle-ci s’inscrit dans le cadre de réformes plus larges en matière de santé numérique. La réussite de la mise en œuvre nécessite non seulement une infrastructure numérique, mais aussi le développement des ressources humaines, une gouvernance éthique, la transparence ainsi que des mécanismes d’intégration des données numériques dans la prise de décision en matière de santé publique. SITUACIÓN: Los métodos tradicionales de vigilancia epidemiológica suelen verse limitados por retrasos en la notificación y por sistemas de datos fragmentados. Arabia Saudí se enfrenta además a desafíos de salud pública derivados de las concentraciones masivas de personas durante el Hach y la Umrah, del aumento de la carga de las enfermedades no transmisibles y de la rápida urbanización, lo que destaca la necesidad de invertir en epidemiología digital. ENFOQUE: Arabia Saudí ha acelerado la transformación digital de la atención sanitaria mediante las iniciativas de la Visión 2030. Las estrategias incluyen plataformas de intercambio de información sanitaria, análisis basados en inteligencia artificial, servicios de telemedicina y sistemas digitales de vigilancia utilizados durante el Hach. Se examinan las iniciativas actuales de inversión en epidemiología digital en Arabia Saudí, los desafíos para su implementación y las prioridades en materia de políticas. MARCO REGIONAL: El sistema sanitario de Arabia Saudí funciona bajo un modelo predominantemente público. El ministerio de salud es el principal proveedor, regulador y financiador de la mayoría de los servicios sanitarios. La cobertura sanitaria es prácticamente universal y la ciudadanía recibe servicios gratuitos a través del sistema público. Las reformas en curso tienen por objeto descentralizar gradualmente determinadas funciones. CAMBIOS IMPORTANTES: Las iniciativas de la Visión 2030 han fortalecido la vigilancia de enfermedades, la integración de datos y la capacidad de respuesta en salud pública. Las reformas existentes en materia de salud digital han creado una base para integrar la epidemiología digital en la práctica habitual de la salud pública. No obstante, persisten desafíos, entre ellos la interoperabilidad fragmentada entre instituciones, la escasez de personal, las desigualdades en el acceso digital y las preocupaciones relacionadas con la gobernanza de los datos, la privacidad y los sesgos algorítmicos. LECCIONES APRENDIDAS: La experiencia de Arabia Saudí sugiere que la epidemiología digital es más eficaz cuando se integra en reformas más amplias de salud digital. Su implementación satisfactoria requiere no solo infraestructura digital, sino también desarrollo de capacidades del personal, gobernanza ética, transparencia y mecanismos para incorporar los datos digitales a la toma de decisiones en salud pública. المشكلة: غالبًا ما تكون طرق الرصد الوبائي التقليدية محدودة بسبب التأخيرات في الإبلاغ وأنظمة البيانات المشتتة. وتواجه المملكة العربية السعودية تحديات إضافية في مجال الصحة العامة نتيجة للتجمعات الكبيرة خلال موسمي الحج والعمرة، وتزايد عبء الأمراض غير المعدية، والتوسع الحضري السريع، مما يُبرز الحاجة إلى الاستثمار في علم الأوبئة الرقمي. الأسلوب: سارعت المملكة العربية السعودية في التحول الرقمي في مجال الرعاية الصحية من خلال مبادرات رؤية 2030. وتشمل هذه الاستراتيجيات منصات تبادل المعلومات الصحية، والتحليلات المدعومة بالذكاء الاصطناعي، وخدمات العلاج الطبي عن بُعد، وأنظمة المراقبة الرقمية المستخدمة خلال موسم الحج. نستعرض في هذا البحث المبادرات الحالية للاستثمار في علم الأوبئة الرقمي في المملكة العربية السعودية، وتحديات التنفيذ، وأولويات السياسة الحكومية. المواقع المحلية: يعمل النظام الصحي في المملكة العربية السعودية بموجب نموذج حكومي بشكل رئيسي. وتُعد وزارة الصحة هي المزود الرئيسي، والجهة المنظمة، والممول لمعظم خدمات الرعاية الصحية. وتعد تغطية الرعاية الصحية شاملة تقريبًا، حيث يحصل المواطنون على الخدمات مجانًا من خلال النظام الحكومي. وتهدف الإصلاحات الجارية إلى تطبيق اللامركزية تدريجيًا على وظائف محددة. التغيّرات ذات الصلة: إن المبادرات بموجب رؤية 2030 تدعم رصد الأمراض، وتكامل البيانات، وقدرات الاستجابة في مجال الصحة العامة. لقد أدت إصلاحات الصحة الرقمية إلى إنشاء أساس لدمج علم الأوبئة الرقمي في ممارسات الصحة العامة الروتينية. ومع ذلك، لا تزال هناك تحديات، تشمل التشغيل المشترك المشتت بين المؤسسات، ونقص الكوادر، والوصول غير العادل إلى البيانات الرقمية، والمخاوف المتعلقة بحوكمة البيانات، والخصوصية، والتحيز الخوارزمي. الدروس المستفادة: تشير تجربة المملكة العربية السعودية إلى أن علم الأوبئة الرقمي يكون أكثر فعالية عند دمجه ضمن إصلاحات أوسع نطاقًا في مجال الصحة الرقمية. ويتطلب التنفيذ الناجح ليس فقط بنية تحتية رقمية، بل أيضًا تطوير القوى العاملة، والحوكمة الأخلاقية، والشفافية، وآليات دمج البيانات الرقمية في عملية صنع القرار في مجال الصحة العامة. 问题: 传统流行病学监测手段常受制于报告滞后与数据系统碎片化的问题。沙特阿拉伯还面临朝觐与副朝期间大型聚众活动、非传染性疾病负担攀升以及快速城市化带来的额外公共卫生难题，凸显出投资发展数字流行病学的必要性。. 方法: 沙特阿拉伯依托《2030 愿景》(Vision 2030) 相关举措，加快推进医疗健康领域数字化转型。相关举措包括医疗信息交互平台、人工智能驱动的数据分析、远程医疗服务以及朝觐期间启用的数字化监测系统。本文梳理了沙特阿拉伯的当前数字流行病学投资项目、项目实施方面的挑战及政策优先发展方向。. 当地状况: 沙特阿拉伯的医疗卫生体系以公立运营模式为主。卫生部是大多数医疗护理服务的主要提供方、监管机构和出资主体。医疗卫生保障基本实现全民覆盖，本国公民可通过公立医疗体系免费就医。现行改革旨在逐步下放部分职能。. 相关变化: 《2030 愿景》框架下的各项举措，助力完善疾病监测、数据整合与公共卫生应急处置能力建设。现有的数字医疗改革为将数字流行病学融入常规公共卫生工作奠定了基础。然而，仍存在一些挑战：医疗机构间数据互通割裂、人才短缺、数字资源获取不均衡，以及数据治理、隐私安全与算法偏见等隐患问题。. 经验教训: 沙特阿拉伯的实践经验表明，将数字流行病学融入大范围数字医疗改革体系中，其实施成效更佳。实施成功不仅需要数字化基础设施，还需人才队伍建设、合规伦理治理、信息公开制度，以及把数字化数据纳入公共卫生决策的配套机制。. ПРОБЛЕМА: Традиционные методы эпидемиологического надзора часто ограничены задержками в предоставлении отчетности и фрагментированностью систем данных. Саудовская Аравия сталкивается с дополнительными проблемами общественного здравоохранения, связанными с массовыми скоплениями людей во время хаджа и умры, растущим бременем неинфекционных заболеваний и стремительной урбанизацией. Все это подчеркивает необходимость инвестиций в цифровую эпидемиологию. ПОДХОД: Саудовская Аравия ускорила цифровую трансформацию здравоохранения в рамках инициатив программы Vision 2030. Среди ключевых направлений – платформы для обмена медицинской информацией, аналитические системы на основе искусственного интеллекта, телемедицинские сервисы и цифровые системы мониторинга, используемые во время хаджа. Авторы рассматривают текущие инвестиционные инициативы в области цифровой эпидемиологии в Саудовской Аравии, проблемы внедрения и приоритетные направления политики. МЕСТНЫЕ УСЛОВИЯ: Система здравоохранения Саудовской Аравии опирается преимущественно на государственную модель. Министерство здравоохранения является основным поставщиком медицинских услуг, регулятором и главным источником финансирования большинства медико-санитарных услуг. Охват медицинской помощью практически всеобщий: граждане получают услуги бесплатно через государственную систему. Текущие реформы направлены на постепенную децентрализацию отдельных функций. ОСУЩЕСТВЛЕННЫЕ ПЕРЕМЕНЫ: Инициативы в рамках программы Vision 2030 способствовали развитию эпидемиологического надзора, интеграции данных и укреплению потенциала реагирования системы общественного здравоохранения. Проводимые реформы в области цифрового здравоохранения заложили фундамент для внедрения цифровой эпидемиологии в повседневную практику общественного здравоохранения. Однако сохраняются проблемы, включая недостаточную совместимость информационных систем разных учреждений, нехватку кадров, неравномерный доступ к цифровым технологиям, а также вопросы управления данными, конфиденциальности и алгоритмической предвзятости. ВЫВОДЫ: Опыт Саудовской Аравии показывает, что цифровая эпидемиология наиболее эффективна, когда интегрирована в более широкие реформы цифрового здравоохранения. Для успешного внедрения необходима не только цифровая инфраструктура, но и развитие кадрового потенциала, этическое регулирование, прозрачность и механизмы интеграции цифровых данных в процессы принятия решений в сфере общественного здравоохранения.
2 Aug 2026
Read appraisal →Current obesity reports
A Systematic Review of Community-based Interventions to Promote Physical Activity or Reduce Sedentary Behavior among Adults in Low- and Middle-Income Countries
PURPOSE OF REVIEW: Community-based interventions (CBIs) are widely used to address behavioral risk factors for non-communicable diseases, yet evidence of their effectiveness in low- and middle-income countries (LMICs) remains limited. This study systematically reviewed evidence on the effectiveness of CBIs promoting physical activity (PA) and/or reducing sedentary behavior (SB) among community-dwelling adults in LMICs. We searched PubMed, Embase, Scopus, and the Cochrane Library (2000-2024) for CBIs in LMICs. Primary outcomes were changes in PA and/or SB. Descriptive and graphical depictions were used to draw inferences. RECENT FINDINGS: We selected 24 studies (11 RCTs) from 15,396 for review. Most studies (n = 16) reported significant improvements in PA outcomes. Changes were observed in Metabolic Equivalents (+ 100 - +2,700), moderate-to-vigorous PA (+ 7 to + 60 min/week), and steps/day (+ 3,000). Broadly, interventions were delivered using digital/technology format (n = 10), peer-led/community health worker-facilitated (n = 8), and Environmental restructuring (n = 6), with the digital interventions depicting the most consistent significant improvements. Two studies directly measured SB as a primary outcome. Short- (≤ 6 months; n = 11) and medium-duration (6-12 months; n = 4) interventions more frequently reported significant PA improvements than long-duration interventions (> 12 months; n = 9). PA/SB-focused CBI demonstrated proportions of significant effects similar to those of broader lifestyle interventions (88.9% and 53.3%, respectively). CBIs can be effective in improving PA in LMICs, although evidence is heterogeneous and SB is less addressed. Digital interventions show more consistent positive signals, but high heterogeneity in studies precludes firm conclusions. The impact of duration on effectiveness looks counterintuitive but underscores the need for more rigorous evaluation of longer-duration interventions and SB outcomes. PROSPERO registration number: CRD42024579461.
23 July 2026
Read appraisal →Molecular genetics and genomics : MGG
The use of artificial intelligence in advancing molecular biology in Africa: a narrative review
Artificial intelligence (AI) is rapidly becoming a core methodological pillar of molecular biology and precision medicine, and Africa is a uniquely consequential setting for this transition because the continent combines the world's greatest human genomic diversity with the most severe underrepresentation of that diversity in the datasets and reference resources on which AI models are built and benchmarked. This narrative review examines, for a genetics and genomics readership, where AI-driven methods are already strengthening African molecular biology, where the supporting evidence remains preliminary, and what is required to translate technical capability into scientifically robust and equitable benefit. The central argument is that AI is especially consequential in African molecular biology, not simply because it automates analysis, but because it can help unlock insight from African genomic diversity, pathogen biology, and clinically relevant multi-omics data that remain underrepresented in global models. Across core molecular domains, AI is accelerating protein structure prediction, high-throughput variant calling and pan-genomic reference construction, genome-wide association analysis, transcriptomic interpretation, drug discovery, and CRISPR guide design. African initiatives such as H3Africa, the African Genome Variation Project, H3ABioNet, and the H3D Centre show that locally generated datasets and African-led computational pipelines can already support meaningful discovery, from improved variant interpretation to structure-guided therapeutic prioritization. At the same time, persistent barriers remain, including underrepresentation of African genomes in training data and reference genomes, uneven computational infrastructure, limited interdisciplinary training, fragmented governance, and the risk that AI-derived benefits will remain inaccessible to the populations whose data enable them. We conclude that the future impact of AI in African molecular biology will depend less on adopting global tools in the abstract and more on building African-led datasets, validation pipelines, governance frameworks, and translational pathways that make molecular discovery both scientifically robust and equitably useful. Looking ahead, the central perspective offered by this review is that Africa's exceptional genomic diversity should be treated as a scientific asset rather than an analytical liability: realising this will require population-representative pan-genome references, sustained computational capacity, and governance structures that ensure African populations are not only the source of the underlying data but also the principal beneficiaries of the discoveries it enables.
23 July 2026
Read appraisal →BMJ open
Determinants of cervical screening in Ghana: a systematic review
BACKGROUND: Cervical cancer remains a leading cause of morbidity and mortality among women in Ghana, yet screening coverage is extremely low and organised national programmes are limited. Although several studies have examined determinants of screening, no comprehensive synthesis has summarised the evidence to guide effective policy and intervention design. OBJECTIVE: To synthesise existing evidence on determinants of cervical screening in Ghana and identify opportunities to strengthen national screening strategies. DESIGN: This is a systematic review conducted following Aromataris and Pearson's methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Searches across PubMed Central, CINAHL, Web of Science, Scopus and grey literature (January 2000-July 2025) identified studies reporting barriers and facilitators of cervical screening in Ghana. Risk of bias was assessed using standard appraisal tools. SETTING: This study was conducted in the context of Ghana. RESULTS: Of 7833 records screened, 32 studies met inclusion criteria. Barriers to cervical screening spanned individual, interpersonal, health system, socio-cultural and structural factors, including poor knowledge, fear, limited access, financial constraints and social norms. Facilitators included knowledge and awareness, provider recommendation, social support, positive health perceptions, healthcare access and cost-related enablers. Overall, 23 studies were rated low risk of bias, while nine were rated moderate risk of bias. CONCLUSION: Cervical screening behaviour in Ghana is influenced by structural, cultural, psychological and informational factors. The reviewed evidence suggests that these determinants do not operate in isolation but interact in ways that may vary across contexts and populations. OSF REGISTRATION NUMBER: https://doi.org/10.17605/OSF.IO/M4XKT.
11 July 2026
Read appraisal →Transactions of the Royal Society of Tropical Medicine and Hygiene
Predicting challenges and opportunities in improving snakebite envenoming management in Ghana
BACKGROUND: Snakebite envenoming (SBE) is a neglected tropical disease and a major public health crisis in Africa. We integrated a maximum difference experimental design and machine learning (ML) models to predict challenges and opportunities for improving SBE management in Ghana. METHODS: This cross-sectional study included 137 healthcare workers, identified through multistage sampling, from August to December 2024 in two districts of the Eastern Region, Ghana. We employed five-fold cross-validation and analysed the dataset using 12 ML models. RESULTS: The most significant obstacle to managing SBE was 'delayed health-seeking behaviour by patients', followed by 'high cost of treatment' and 'inadequacy/shortage of antivenom'. On the opportunity side, 'increasing public awareness and knowledge about snakebite prevention and initial management before reaching a healthcare facility' was deemed crucial. Other opportunities such as 'conducting research into alternative management for snakebite to complement or replace antivenoms' and 'increasing awareness and knowledge about snakebite management among healthcare workers' were also recognized as trade-offs. CONCLUSIONS: This study significantly contributes to the existing research on artificial intelligence/ML, as previous studies have not quantified the challenges and opportunities in managing SBE. Policymakers and healthcare providers can use these findings to implement strategies such as promoting better health-seeking behaviours, subsidizing treatment costs, ensuring access to effective antivenom and raising public awareness about snakebite prevention and initial care.
9 July 2026
Read appraisal →Transactions of the Royal Society of Tropical Medicine and Hygiene
Atomic clarity: how structural biology is shaping blood-stage malaria vaccines
Developing an effective malaria vaccine is challenging because Plasmodium parasites use complex strategies to invade host cells. The blood stage, where parasites replicate inside red blood cells, causes disease symptoms and relies on large multiprotein surface complexes that are difficult to target. Understanding their structure is essential for rational vaccine design. Cryogenic electron microscopy (cryoEM) enables atomic-level analysis of dynamic and membrane-associated complexes without crystallization, revealing key processes such as protein trafficking, nutrient uptake, and host cell remodeling. Recent advances in artificial intelligence and deep learning have improved cryoEM data analysis and structural modeling. Together with genomic data, this integrated approach is accelerating progress toward broadly protective malaria vaccines.
9 July 2026
Read appraisal →Transactions of the Royal Society of Tropical Medicine and Hygiene
Extreme weather effects on health services and communities in low and lower-middle income countries: a thematic systematic review
Most previous research about the dangers of extreme weather events was applicable to populations in high-income countries. Data summarising harms related to extreme weather events in low-income settings are lacking. A systematic review thematically summarising evidence about weather event-linked harms and responses in low- and lower-middle-income countries was conducted. Peer-reviewed and grey literature was systematically searched and selected. Data were extracted about harms, responses and outcomes relevant to six WHO building blocks of healthcare systems. Framework analysis was used to identify predominant themes related to harms, responses and the WHO building blocks. In total, 183 reports were included. Flooding and high winds were the most common types of extreme weather events documented. The main community experience themes identified were the displacement of populations and disruption. The main themes identified for health service delivery were vulnerability, disruption and resilience. Documented examples of resilience or recovery were far fewer for all six WHO healthcare system building blocks than descriptions of vulnerability and disruption. Extreme weather events can be highly disruptive and harmful to healthcare systems and communities in LMIC settings that are often already highly vulnerable.
8 July 2026
Read appraisal →Journal of global health
Leapfrogging medical infrastructure: a novel bilateral exchange model driven by digital medicine in Kazakhstan.
The geographic maldistribution of highly specialised neurosurgical care in Central Asia, particularly Kazakhstan, presents a critical challenge driven by medical education pipeline constraints and brain drain. Traditional assistance models relying on short-term missions or conventional hardware donations are insufficient to bridge this fundamental infrastructural gap. We present a novel 'Bilateral Medical Exchange Model' established between Showa Medical University in Japan and top Kazakh medical institutions. By utilising advanced digital medicine - specifically, high-performance computing-driven artificial intelligence and 3D extended reality visualisation - as the primary diplomatic catalyst, this framework successfully engaged both grassroots clinicians and top-tier government officials. We highlight how targeting these technologies toward localised capacity building and edge-computing infrastructure circumvents traditional barriers. While long-term clinical outcomes remain to be systematically evaluated, this technology-driven diplomatic approach provides a foundational, hypothesis-generating framework for bridging the digital divide, integrating digital innovation with decentralised education to ultimately improve equitable patient outcomes in transitioning economies.
6 July 2026
Read appraisal →International health
Antimicrobial stewardship interventions currently implemented at primary healthcare settings across low- and lower-middle-income countries (LLMICs)
BACKGROUND: Antimicrobial resistance (AMR) is a top global public health and development threat. Antimicrobial stewardship programs (AMSPs) are one of the most cost-effective interventions to optimize the use of antimicrobials. This study reviews AMSPs that have been implemented in low- and lower middle-income countries. METHODS: A systematic search was conducted on electronic databases including MEDLINE, PubMed, Embase, OVID, Web of Science and Cochrane Library on 18 July 2024 for published papers from 2014 to 2024 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Relevant published literature was then selected based on the established inclusion/exclusion criteria. Each article was screened by two independent reviewers. Data were extracted and synthesized in the review. RESULTS: Of the 425 articles screened, only 13 were eligible for review and included in this study. Two studies were multinationals. Five studies were randomized controlled trials. Among the three key focuses of AMSPs, most of the interventions focused on optimizing antibiotic use (n=8), followed by improving diagnostics and monitoring (n=3) and education and training (n=2). The most commonly reported barriers to implementing AMSPs was a lack of resources (n=9). Facilitators reported included knowledge of AMS (n=8), availability of educational and training resources (n=8), adequate funding (n=6), accountable and transparent procedures (n=5) and positive communication within healthcare facilities (n=4). CONCLUSIONS: All included studies show improvement in AMS through innovative programs. However, only a few have been adopted nationwide and influence policy formulation in the country. We recommend adoption of effective AMSPs into the national strategic planning and implementation across primary health settings.
5 July 2026
Read appraisal →BMJ global health
Lifestyle interventions for dementia prevention in low- and middle-income countries: a systematic review.
INTRODUCTION: By 2050, two-thirds of people with dementia will live in low-and-middle-income countries (LMICs). However, multimodal prevention lifestyle interventions for people at risk are being developed predominantly in higher-income countries. METHODS: We systematically reviewed randomised controlled trials (RCTs) evaluating non-pharmacological interventions in individuals with mild cognitive impairment and subjective cognitive decline in LMICs. We assessed quality using the Mixed Methods Assessment Tool, meta-analysed and synthesised evidence. RESULTS: We included 25 RCTs from six countries (most in China, n=17), involving 1304 participants. In the 15 studies with sufficient data to meta-analyse, we found significant positive effects on cognition favouring interventions (1.49 (standardised mean difference, 95% CI 1.06 to 1.93)). There was significant publication bias. We classified interventions into exercise, multidomain and arts/creative expression. Exercise (1.67, 95% CI 1.24 to 2.11, n=8) and multidomain (1.22, 95% CI 0.22 to 2.21, n=5) had replicated evidence of effectiveness. There was insufficient data to meta-analyse the arts/creative category. CONCLUSION: We propose greater consideration and investment in the development of interventions accounting for specific LMIC contexts from the outset, so they are acceptable and used by local services. PROSPERO REGISTRATION NUMBER: CRD42023403908.
24 June 2026
Read appraisal →BMJ paediatrics open
Smartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala
OBJECTIVE: To test the feasibility of a smartphone app, BebeApp, that provides evidence-based early childhood development (ECD) guidance in rural Guatemala and pilot procedures for an adequately powered randomised controlled trial. DESIGN: We conducted an individually randomised pilot feasibility trial to compare BebeApp to printed ECD guidance. SETTING: This trial was conducted in Tecpán, Chimaltenango, a semi-rural community that is 95% Kaqchikel Indigenous Maya. PATIENTS: First-time primary caregiver-infant (0-28 days) dyads. INTERVENTIONS: BebeApp provides age-dependent, evidence-based caregiver guidance for breastfeeding and complementary feeding, sleep and developmental support. MAIN OUTCOME MEASURES: A mixed-methods evaluation of BebeApp's implementation and acceptability using the Reach, Effectiveness, Adoption, Implementation, Maintenance framework. App usability, usefulness and satisfaction were assessed via questionnaires, semi-structured interviews and app interaction data. RESULTS: 41 infant-caregiver dyads were enrolled with 40 completing the study. Engagement was high with caregivers opening BebeApp a median (IQR) 11 (6-21) times per month. Usability was found to be acceptable but no difference was found between pre-measurements and post-measurements. In interviews, caregivers expressed some initial difficulty using BebeApp but were able to gain confidence with a training session. App usefulness and satisfaction responses were positive. Caregivers often noted that BebeApp was their only source of ECD information outside of their family. CONCLUSIONS: We found that caregivers in rural Guatemala responded positively to a smartphone ECD app and engaged with it throughout the trial. Given the urgent need for ECD programmes in low- and middle-income settings, smartphone apps may be a method to deliver services directly to caregivers.
14 June 2026
Read appraisal →Global health action
mHealth-supported tuberculosis contact investigation by community health workers in high-burden countries: a scoping review
Mobile health (mHealth) implementation strategies in tuberculosis (TB) contact investigations are intended to increase community health workers' (CHWs) engagement in TB contact investigations and case detection. This scoping review aimed to map and synthesize existing evidence on the design and development of acceptable and feasible mHealth implementation strategies for CHW-led TB contact investigations. We conducted a scoping review following the Arksey and O'Malley framework and PRISMA-ScR guidelines. We searched PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar for English-language studies published through October 2024 on mHealth interventions for TB contact investigation by CHWs. Eligible studies included empirical studies conducted in high-burden countries (HBCs) for TB, HIV-associated TB, and MDR/RR-TB. Studies were screened, and data were extracted using Rayyan AI-assisted software. We mapped implementation strategies, barriers, facilitators, acceptability, and feasibility of mHealth interventions. Quantitative findings were described, and qualitative data were synthesized thematically. Nine studies were included. Most interventions used hybrid mHealth technologies for communication, case registration, health records, and decision support. Implementation strategies specified actors, actions, targets, temporality, dose, and justifications. Barriers were related to CHWs, digital systems, service implementation, and TB-affected persons. Facilitators included stakeholder support, CHW training, mHealth design, community engagement, and patient-centered approaches. Overall, CHWs perceived mHealth interventions as acceptable and feasible. Successful implementation in HBCs requires strengthened CHW capacity, reliable technology, optimizing interaction between CHWs and digital tools, and continuous monitoring and evaluation throughout implementation. Main findings: Health interventions for tuberculosis contact investigation by community health workers in three global lists of high-burden countries for tuberculosis, human immunodeficiency virus-associated tuberculosis, and multidrug-resistant/rifampicin-resistant tuberculosis are generally acceptable and feasible, but their effectiveness depends heavily on a clear implementation strategy and the ability to address multilevel barriers at the individual, technology, and service system levels.Added knowledge: Given the ongoing development of digital health interventions for TB contact investigation by community health workers, this review provides a novel contribution by systematically mapping seven dimensions of implementation strategies, classifying barriers and facilitators at multiple levels, and highlighting the importance of synergies between human actors and digital systems in determining implementation success.Global health impact for policy and action: These findings confirm that strategic integration of mHealth into national tuberculosis policies and programs – with sustained funding, community health worker capacity building, digital system interoperability, and implementation-based monitoring – is crucial for closing the contact investigation gap and accelerating the achievement of the global tuberculosis elimination target.
11 June 2026
Read appraisal →BMJ paediatrics open
Impact of flash glucose monitoring versus capillary blood glucose monitoring on glycaemia in Indian youth with type 1 diabetes: a randomised crossover study
BACKGROUND: Data relating to flash glucose monitoring (FGM) use in low-resource settings are limited. Our study investigated the impact of FGM versus self-monitoring of blood glucose (SMBG) on glycaemia in Ahmedabad, India. METHODS: A randomised crossover study of FGM versus SMBG was undertaken. Participants aged 10-25 years (type 1 diabetes (T1D)>1 year) were randomised 1:1 to either Freestyle Libre 1 FGM use (intervention) for 6 months, followed by SMBG≥4 times/day (local care standard) for 6 months; or SMBG≥4 times/day, followed by FGM. After 12 months, everyone entered a 6-month observation period using the monitoring method choice. Insulin and dietary adjustments were undertaken as per local care standards. Glycated haemoglobin (HbA1c) was measured at 0, 3 and 6 months (period 1) and 9 and 12 months (period 2). Analyses included use of linear mixed-effects analysis of covariance, a paired Wilcoxon signed-rank test, and cumulative link mixed tests and model. RESULTS: Of 106 participants, 91 (86%) completed 12 months follow-up (47.3% female). At baseline, mean±SD age was 17.8±3.8 years, diabetes duration 9.9±5.0 years and HbA1c 8.6±1.9% (70±21 mmol/mol).HbA1c decreased when using FGM versus SMBG (difference -0.44% (4.8 mmol/mol); p=0.006), with greater reduction in those with higher baseline HbA1c (p=0.003). In the FGM→SMBG group, HbA1c initially decreased from 8.6±2.2% (70±24 mmol/mol) to 7.9±1.1% (62±12 mmol/mol) at 3 and 6 months (both p<0.05). After SMBG crossover, HbA1c was unchanged (7.9±1.1% (63±12 mmol/mol) at 9 months and 8.1±1.3% (65±14 mmol/mol) at 12 months). In the SMBG→FGM group, HbA1c was initially stable (8.6±1.4% (70±15 mmol/mol) at baseline; 8.8±1.7% (73±19 mmol/mol) at 6 months), but decreased after crossover to FGM (8.4±1.4% (68±15 mmol/mol) at 9 months; 8.3±0.9% (67±10 mmol/mol) at 12 months; p=0.023). CONCLUSION: This study provides evidence of improvement in glycaemic outcomes while using FGM in youth living with T1D in India. TRIAL REGISTRATION NUMBER: Clinical Trial Registry of India (CTRI/2022/02/020175).
1 June 2026
Read appraisal →PloS one
Effect of digitizing Community Health Information System on the delivery and use of maternal and child health services: Propensity score matching analysis
INTRODUCTION: In 2018, Ethiopia's government digitized its Community Health Information System (eCHIS) to enhance Health Extension Program service delivery. However, the impact of eCHIS on health outcomes remains unclear. This study, therefore, examined the effects of eCHIS on the uptake of maternal and child health services. METHODS: A post-test-only, non-equivalent group household survey design was used, collecting data from July to August 2024 in rural communities with and without eCHIS. A stratified multistage sampling technique was employed to recruit respondents. A sample of 1,728 women of reproductive age (271 in eCHIS and 1,457 in non-eCHIS woredas), 1,118 women with children ages 0-11 months (188 in eCHIS and 930 in non-eCHIS), and 569 women with children ages 12-23 months (301 in eCHIS and 268 in non-eCHIS) were included in this study. Propensity scores were used to match intervention and comparison communities based on women's age, religion, parity, education, household wealth, distance to health facilities, and autonomy. A modified Poisson regression analysis, adjusting for covariates, was conducted to estimate the adjusted prevalence ratios (PR) for maternal and child health outcomes. RESULTS: Modern contraceptive use was 66% in intervention areas versus 56% in comparison areas. Institutional delivery rates were 95% in intervention and 79% in comparison areas. In intervention areas, 94% of children received the first dose of the Pentavalent vaccine compared to 83% in comparison areas, while 85% and 68%, respectively, received the third dose. Adjusted analyses showed that eCHIS intervention areas had statistically significant increases in contraceptive use (13.0 percentage points; PR: 1.25; p-value < 0.01) and institutional deliveries (8.9 percentage points; PR: 1.18; p-value < 0.01) compared to comparison areas. Similarly, the average treatment effect of eCHIS on Pentavalent 1, Pentavalent 3, and full vaccination coverage showed significant increases of 10.3 (PR: 1.13; p-value < 0.01), 13.6 (PR: 1.26; p-value < 0.01), and 14.6 (PR: 1.36; p-value < 0.01) percentage points, respectively. CONCLUSION: This study underscores the transformative potential of eCHIS in improving maternal and child health outcomes in Ethiopia. Sustained investment in digital health systems can help scale effective health care services to rural and underserved communities.
31 May 2026
Read appraisal →Journal of global health
Global, regional, and national trends in blindness and vision loss, 1990-2021: a secondary ecological trend analysis based on modelled population estimates.
BACKGROUND: We aimed to provide global, regional, and national estimates of the burden of blindness and vision loss from 1990 to 2021, stratified by cause, age, and sociodemographic index (SDI). METHODS: This population-based study used data from the 2021 Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD) study, covering 1990 to 2021. It evaluates the burden of blindness and vision loss based on prevalence, age-standardised prevalence rate (ASPR), disability-adjusted life years (DALYs), age-standardised DALY rate (ASR of DALY), and average annual percent changes (AAPCs). RESULTS: Globally, the ASPR of blindness and vision loss increased from 12 453.52 (95% uncertainty interval (UI) = 10 287.58, 15 226.09) in 1990 to 15 784.33 (95% UI = 12 761.44, 19 502.32) in 2021, with an AAPC of 0.85 (95% confidence interval (CI) = 0.7, 1.11, P < 0.001). In contrast, the ASR of DALYs remained stable, changing from 342.01 (95% UI = 237.87, 482.17) in 1990 to 342.78 (95% UI = 224.21, 503.61) in 2021, with an AAPC of 0.05 (95% CI = -0.04, 0.2, P = 0.298). Notably, near vision loss and cataract showed consistent increases, with AAPCs of 1.14 (95% CI = 0.94, 1.51, P < 0.001) and 0.25 (95% CI = 0.16, 0.33, P < 0.001), respectively. Blindness and vision loss prevalence was significantly higher in low and low-middle SDI regions compared to other SDI regions. CONCLUSIONS: Global blindness and vision loss increased from 1990 to 2021, while DALYs stayed stable. Prevention should be tailored by region, country, gender, cause, and age.
31 May 2026
Read appraisal →African journal of reproductive health
Reproductive health in the digital and social age: AI, education, law, and community-based interventions.
Reproductive health has increasingly emerged as a complex, multidimensional field that extends far beyond clinical care into the domains of education, technology, law, culture, and socio-economic systems. This special issue of the African Journal of Reproductive Health brings together fifteen diverse yet interconnected papers that collectively illuminate how reproductive health outcomes are shaped by dynamic interactions across disciplines, geographies, and social structures. The contributions - spanning China, Spain, and Pakistan - underscore a unifying premise: that sustainable reproductive health improvements depend on integrative approaches that harness innovation while remaining grounded in cultural and social realities. La santé reproductive s'affirme de plus en plus comme un domaine complexe et multidimensionnel qui dépasse largement le cadre des soins cliniques pour englober l'éducation, la technologie, le droit, la culture et les systèmes socio-économiques. Ce numéro spécial de l'African Journal of Reproductive Health rassemble quinze articles divers mais interconnectés qui, ensemble, mettent en lumière la manière dont les résultats en matière de santé reproductive sont façonnés par des interactions dynamiques entre disciplines, territoires et structures sociales. Ces contributions, provenant de Chine, d'Espagne et du Pakistan, soulignent un principe unificateur : l'amélioration durable de la santé reproductive repose sur des approches intégratives qui exploitent l'innovation tout en restant ancrées dans les réalités culturelles et sociales.
30 May 2026
Read appraisal →Neurosurgical review
Modified tubular retractor for deep brain tumour resection: enhanced surgical outcomes in resource-constrained settings
Tubular retractors permit minimally invasive access to deep-seated intracranial tumours; however, limitations in visualisation and manoeuvrability reduce their suitability for lesions ≥ 3 cm, particularly in resource-limited centres. We evaluated a modified, low-cost tubular retractor incorporating enhanced visualisation and ergonomic features, comparing its performance with Leyla spatula-based retraction and traditional syringe-derived tubular systems. A prospective comparative cohort of 105 patients with deep brain tumours ≥ 3 cm was analysed. Patients underwent Leyla retraction (Group 1, n = 38), conventional tubular systems (Group 2, n = 32), or a modified tubular retractor (Group 3, n = 35). Outcomes included intraoperative visualisation, retractor stability, manoeuvrability, extent of resection, complications, and three-month Glasgow Outcome Scores. Owing to non-normal distribution, continuous variables were analysed using non-parametric tests and binary logistic regression. The modified tubular retractor demonstrated greater stability, broader visualisation, and enhanced instrument handling compared with conventional tubular systems. Gross total resection was achieved in 91.4% with the modified device, 78.9% with Leyla-based retraction, and 28.9% with traditional tubular systems. Logistic modelling identified retractor type (OR 2.59, p = 0.035), intraoperative visualisation (OR 2.01, p = 0.036), and histopathology (OR 1.41, p = 0.036) as independent predictors of residual tumour. The modified retractor group exhibited fewer complications, shorter ICU stays, and superior functional outcomes (GOS ≥ 4 in 91%). The modified tubular retractor demonstrated favourable operative handling and outcome trends for deep-seated tumours ≥ 3 cm, with improved visualisation, stability, and ergonomic access compared with conventional systems. However, limitations related to non-randomised design, learning-curve effects, advanced mapping, fluorescence integration, and supramaximal resection warrant cautious interpretation pending multicentre long-term validation.
29 May 2026
Read appraisal →PloS one
Determinants of maternal postnatal care utilization in Bangladesh: A machine learning and SHAP-based analysis of BDHS 2022 data
Postnatal care (PNC) plays a crucial role in minimizing maternal and neonatal morbidity and mortality, but the uptake of services in Bangladesh remains below the recommended level. Although logistic regression has been widely used, it may miss complex nonlinear interactions among social, economic, and healthcare factors. This study contributes to the body of knowledge by using machine learning (ML) to identify the most significant determinants of PNC and to enhance prediction accuracy. We compared logistic regression to several ML models, including Random Forest, XGBoost, CatBoost, Support Vector Machine, AdaBoost, and Gradient Boosting, using nationally representative data from the 2022 Bangladesh Demographic and Health Survey (BDHS) with ADASYN oversampling to correct class imbalance. Among all models, Random Forest achieved the highest AUC (0.9050), closely followed by XGBoost (0.9036) and CatBoost (0.9028), all of which substantially outperformed logistic regression (AUC = 0.8470). SHAP analysis of the Random Forest model indicated that delivery place, husband's occupation, rural residence, wealth index, and media exposure were the most influential predictors of PNC utilization, alongside maternal education, women's occupation, and age-related factors. The results indicate that ML is more effective than classical procedures for revealing latent patterns and making accurate predictions. Policy implications include encouraging facility-based deliveries, improving maternal education, reducing wealth disparities, and enhancing media coverage of health, particularly among rural and low-income groups. This paper not only identifies key drivers of PNC in Bangladesh but also demonstrates how ML can supplement traditional methods to reinforce maternal health policy and interventions.
28 May 2026
Read appraisal →BMJ open
Prevalence of teenage pregnancy and associated factors in Uganda: a meta-analysis and systematic review
OBJECTIVE: Teenage pregnancy is a major public health problem with huge consequences for maternal health and pregnancy outcomes. This calls for a concerted effort from different stakeholders involved in issues of teenagers' sexual reproductive health to achieve the SDG target of 2030 on the reduction of maternal mortality. The objective of this systematic review was to estimate the prevalence of teenage pregnancy and its associated factors in Uganda. DESIGNS: We conducted a systematic review and random-effects meta-analysis according to Preferred Reporting Items for Systematic Review and Meta-analysis standards. DATA SOURCES: After prospective registration (PROSPERO CRD42023486460), a literature search was conducted in PubMed, African Journals Online and Google Scholar in December 2023. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Observational studies that reported the prevalence of teenage pregnancy among teenagers were included. DATA EXTRACTION AND SYNTHESIS: Articles were screened for relevance at the title, abstract and full-text levels by multiple reviewers. The quality of studies was independently appraised using the Joanna Briggs Institute Critical Appraisal Checklist and Newcastle-Ottawa Scale. Any discrepancies were resolved by reaching a consensus. The process of extracting data included study information, geographical categorisation, type of studies, population, sample size, results/outcomes and prevalence of teenage pregnancy. The risk of bias was determined by Egger's test. The results were pooled using random-effects models to calculate the prevalence of teenage pregnancy with a CI of 95% and I² statistic. RESULTS: Of 918 records screened, 10 studies (4143 participants) were included. The pooled prevalence of teenage pregnancy was 25.5% (95% CI 13.7% to 39.5%; I²=98.9%), with individual study estimates ranging widely from 3.0% to 56.4%, reflecting substantial heterogeneity across study settings, populations and periods of data collection. Higher estimates were observed in the Central-Eastern region (31.7%, 95% CI 19.5% to 45.1%). The overall certainty of evidence was rated as very low using the Grading of Recommendations, Assessment, Development and Evaluation framework, primarily due to very serious inconsistency across included studies (I²=98.9%). CONCLUSIONS: Pooling studies of mixed quality revealed a slightly higher prevalence of teenage pregnancy in Uganda. This review provides valuable insight for policymakers and healthcare providers in developing interventions and policies to reduce the burden of teenage pregnancy from disadvantaged backgrounds. PROSPERO REGISTRATION NUMBER: CRD42023486460.
28 May 2026
Read appraisal →NEJM evidence
Outcomes of Pneumonia in ICUs in Low- and Middle-Income Countries - A Systematic Review
BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of intensive care unit (ICU) admission and death in low- and middle-income countries (LMICs). We conducted a systematic review and meta-analysis to estimate mortality among patients with CAP admitted to ICUs in LMICs. METHODS: We searched multiple databases using terms related to CAP admitted to the ICU and LMIC. We included both observational studies and clinical trials. The primary outcome was all-cause ICU, 28-day or 30-day mortality. Demographics, comorbidities, clinical characteristics, mechanical ventilation, and length of ICU stay were described. We registered the study in PROSPERO (CRD42022363048). RESULTS: A total of 52 studies from 18 countries met inclusion criteria, encompassing 48,707 patients. Most studies originated in upper-middle-income countries and no studies from low-income countries were identified. The most frequent comorbidities were hypertension, chronic obstructive pulmonary disease, and diabetes. Mechanical ventilation was reported in 36 studies, with median use in 59% (interquartile range, 41.4-77.4) of patients. Pooled mortality was 37% (95% confidence interval [CI], 31-42), rising to 61 (44-75) among patients requiring mechanical ventilation. In a meta-regression, age and mechanical ventilation were the strongest moderators of mortality, explaining 55.2% of heterogeneity in short-term mortality. CONCLUSIONS: Mortality among patients with CAP admitted to ICUs in middle-income countries remains high, especially in older and mechanically ventilated patients. The lack of data from low-income countries is notable.
27 May 2026
Read appraisal →Global health action
Integrating GIS and local knowledge for optimised medical supply prepositioning in flood-prone Nigeria: a strategic framework
BACKGROUND: Nigeria faces recurring flood disasters that severely disrupt its healthcare systems and delays medical relief efforts. Current medical supply prepositioning by the National Emergency Management Agency (NEMA) remains inadequate due to infrastructure limitations, funding constraints, and poor coordination. OBJECTIVE: To develop and validate a Strategic Medical Hub Locator Framework that integrates Geographic Information Systems (GIS) analysis with qualitative local knowledge to optimise medical supply prepositioning for flood emergencies in Nigeria. METHODS: We employed a mixed-methods approach, combining qualitative analysis of 22 GIS-based flood risk studies in Nigeria and structured expert survey responses from 34 professionals with flood response experience, including five with direct NEMA warehouse experience. The framework was grounded in Disaster Risk Reduction theory and supported by Protection Motivation Theory and Theory of Planned Behaviour. RESULTS: The framework identified eight strategic medical hub locations: six existing NEMA warehouses (Abuja, Lagos, Kano, Gombe, Maiduguri, Kaduna) with the strongest performance, and two new strategic sites (Akure and Uyo) to address service gaps in South-South and South-East regions. Abuja emerged as the highest-performing hub with a composite score reflecting good centrality, governance capacity, and operational readiness. The framework successfully bridged data silos between spatial flood risk patterns and operational constraints. CONCLUSIONS: Integration of GIS thematic analysis with qualitative local data provides a viable, replicable method for enhancing humanitarian medical logistics in flood-prone regions. The Strategic Medical Hub Locator Framework offers a structured decision-support tool that can inform evidence-based investment in Nigeria's disaster health infrastructure, while being adaptable to other Global South contexts. Key findings: Where primary geospatial data silos are present, GIS analysis can be enhanced by combining it with local qualitative insights, thereby bridging the gap between technical modelling and practitioner realities.Added knowledge: The paper offers a methodological contribution through the design of a Strategic Medical Hub Locator Framework that is replicable in contexts where primary data and complex modelling are not feasible.Global health impact for policy and action: This study provides policymakers and humanitarian actors with a proof-of-concept decision-support tool. The exploratory framework offers a scalable model that can be adapted to other flood-prone settings where primary data and practical knowledge are scattered, thereby strengthening disaster preparedness and health system resilience strategies.
27 May 2026
Read appraisal →Health policy and planning
Partial pictures: what routine health data can and cannot tell us about the quality of maternal and neonatal health services in Tanzania
Measurement of contact coverage of maternal and newborn health services may overestimate the benefits of the care that is provided, because the quality of care is not captured. It is therefore important to better understand the opportunities and challenges of capturing elements of care quality in routine health information systems (RHIS). This study explored healthcare workers' (HCWs), health sector managers' and policymakers' perspectives on the value and limits of routine health data to understand the quality of maternal and neonatal health services in Tanzania. We conducted qualitative research during two periods to capture perspectives across facility, district, regional and national levels. In Mtwara region in 2023, we conducted ethnographic observations at two hospital labour wards and 29 in-depth interviews with healthcare workers, hospital leaders, and district/regional managers. In 2025, we carried out 17 additional interviews with regional managers in Mtwara and with key national-level stakeholders. Our findings demonstrate that Tanzania's RHIS provides a valuable but partial picture of quality of care for maternal and neonatal health services. Care processes-including both provision and experience of care-are captured only to a limited extent. Using boundary object theory, we highlight how the same health information must serve diverse stakeholder needs. While there are opportunities to integrate more quality-of-care indicators, standardized RHIS cannot be expected to comprehensively capture the multifaceted nature of care quality. For quality measurement to support meaningful local health service improvement, a flexible, bottom-up approach is essential. However, the current emphasis on top-down oversight acts as a barrier for local-level data use. Relevant and feasible measurement of the quality of facility-based care requires a fundamental shift in current RHIS priorities-from systems that extract data for those 'up there' to platforms that also create value for those who provide care.
21 May 2026
Read appraisal →Health policy and planning
Pain, policy, and the opioid dilemma in sub-Saharan Africa: a systematic review of access, regulation, and health governance from 1990 to 2024
Sub-Saharan Africa (SSA) faces a dual opioid dilemma: widespread undertreatment of moderate to severe pain due to limited access to essential opioid analgesics, alongside increasing concern about misuse and diversion in selected contexts. Opioids are clinically indicated for severe cancer-related pain, advanced chronic illness, major trauma, surgery, and end-of-life care; yet, regional consumption remains disproportionately low relative to documented disease burden, indicating systemic under-provision rather than low need. This systematic review synthesizes evidence on opioid policy, regulation, access, and governance in SSA to examine how legal frameworks, institutional arrangements, political dynamics, and data systems shape medical availability. Following PRISMA and SWiM guidance, we reviewed peer-reviewed and gray literature addressing national drug control laws, regulatory implementation, procurement and supply systems, prescribing authority, and surveillance capacity; 33 studies met inclusion criteria. Across settings, restrictive or ambiguously interpreted legislation, multi-layered administrative controls, fragmented mandates across health and enforcement institutions, weak forecasting and distribution systems, concentrated prescribing authority, professional risk aversion, and chronic data gaps were consistently associated with constrained access. Concurrently, rising political and media attention to non-medical use, particularly of tramadol, has reinforced enforcement-oriented narratives that may further limit reform space. Persistent deficiencies in routine consumption data and unmet need assessment contribute to conservative import quotas and regulatory inertia. Addressing this imbalance requires proportionate, sequenced reform that strengthens data and forecasting systems, clarifies and aligns legal mandates with public health objectives, invests in workforce capacity and supply chains, and embeds safeguards against diversion while correcting avoidable under-treatment.
21 May 2026
Read appraisal →PloS one
A computational text analysis of recent African digital health strategies and their attention to vulnerable populations
BACKGROUND: Digital health offers opportunities to transform healthcare systems and improve access to care, particularly in low- and middle-income countries. However, there is concern that national digital health strategies may inadequately address the needs of vulnerable populations, risking the reinforcement of existing health inequalities. OBJECTIVE: This study investigates the extent to which recent African national digital health strategies consider and prioritize vulnerable populations particularly at risk of digital exclusion (women, children and the elderly). METHODS: We conducted a computational text analysis of 13 recent national digital health strategy documents from African countries to identify major topical priorities within the strategies and to systematically assess the frequency and context of references to vulnerable populations. RESULTS: Most strategies focus on broad goals such as health system strengthening, infrastructure development, and stakeholder coordination. While there are mentions of women and children, these references are often indirect and not accompanied by concrete plans or dedicated actions. References to the elderly are especially rare. Few strategies include specific measures to ensure digital inclusion or equity for these vulnerable populations. CONCLUSIONS: Recent African digital health strategies currently prioritize systemic and infrastructural development, but the needs of vulnerable populations are often overlooked or superficially addressed. To prevent the digital divide from widening, national strategies should embed explicit equity targets, actionable plans, and mechanisms for meaningful inclusion and participation of all population groups.
20 May 2026
Read appraisal →Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Is iron supplementation likely to impair linear growth and gut microbiota composition of Myanmar young children when complementary feeding is not optimized? A randomized controlled trial.
Iron deficiency, with or without anemia, remains a major public health concern among young children in Myanmar. While iron supplementation is widely recommended, its potential adverse effects on growth and gut microbiota warrant investigation, particularly in contexts of poor complementary feeding. To assess the effects of iron supplementation, with or without complementary feeding recommendations (CFRs), on micronutrient status, linear growth and gut microbiota composition among Myanmar children aged 12-23 months, a 24-week randomized controlled trial was conducted in Ayeyarwady Region of Myanmar. Fourteen clusters (villages/wards) were randomized to receive CFRs or not, and children within the clusters were randomized to receive daily aqueous iron or placebo, creating four arms: Placebo (n = 104), CFR (n = 112), Fe (n = 105) and CFRFe (n = 112) totalling 433 children. All intervention groups (CFR, Fe, CFRFe) improved haemoglobin and reduced anaemia risk compared with Placebo (AOR = 0.31 (0.15-0.62), 0.15 (0.07-0.32), 0.14 (0.07-0.31), respectively). CFR and CFRFe also improved zinc status. However, iron-alone (Fe) increased the stunting risk (AOR= 2.74 (1.04-7.23)), while CFRFe did not. No significant effects were observed on gut microbiota composition. Aqueous iron supplementation may impair linear growth when diets are not optimized; combining supplements with optimized complementary feeding may support healthier outcomes. This article is part of the theme issue 'Biological, biomedical and environmental drivers of stunting'.
17 May 2026
Read appraisal →European journal of preventive cardiology
Elevated blood pressure levels among 533 167 adults living in Sub-Saharan Africa: a systematic review and meta-analysis
AIMS: Synthesizing contemporary data from sub-Saharan African countries, we did a systematic review and meta-analysis of blood pressure (BP) levels and hypertension among adults living in the region. METHODS AND RESULTS: We searched PubMed and other databases to identify studies published from 1 January 2010 to 31 December 2021. We used a random-effects model to estimate the pooled-prevalence of hypertension and mean systolic/diastolic BP overall and on a sex- and age-specific basis. Heterogeneity (I²) was assessed via the χ² test on Cochran's Q statistic. We identified 170 high-quality studies (195 samples) comprising 533 167 adults living in 26 countries. The pooled prevalence of hypertension was 30.5% (95% CI 28.4-32.6%). Overall mean systolic/diastolic BP was 128 (95% CI 127-129)/80 (95% CI 79-80) mmHg, with males recording higher mean BP levels (3.10 [95% CI 2.30-3.90]/0.69 [95% CI 0.10-1.29] mmHg) compared with females. Reflecting increasingly higher BP levels with age, the pooled estimates of hypertension prevalence initially rose three-fold (from 10.6% [95% CI 8.2-13.0%] to 30.9% [95% CI 27.8-34.0%]) in those aged 21-30 to 41-50 years, and then two-fold to 66.4% (95% CI 64.2-68.7%) among those aged 71-80 years, respectively. Hypertension prevalence was lower in healthy weight [28.4% (95% CI 26.1-30.6%)] compared with overweight [35.8% (95% CI 31.4-40.1%)] adults. Regionally, prevalent hypertension was lowest in those living in Eastern Africa [27.2% (95% CI 24.8-29.7%)]. CONCLUSION: Our findings suggest a steep age-related pattern of increasing BP levels in the region that will adversely affect millions of people within the next 10-20 years without urgent intervention. A detailed review and analysis of 170 studies involving more than half a million adult men and women living in 26 sub-Saharan Africa countries, revealed that one in three have elevated blood pressure/hypertension.Elevated blood pressure levels, and the markedly increased risk of suffering a debilitating or fatal cardiovascular event at an early age, rose steeply from around one in ten affected at age 20–30 years to around one in three by the age of 50 years.Beyond the influence of age, the risk of having elevated blood pressure was different, given it increased markedly for overweight men and women, whilst those living in (mainly poorer) Eastern African countries had the lowest blood pressure levels.
16 May 2026
Read appraisal →Journal of global health
Global prevalence of underweight and overweight/obesity among migrant workers: a systematic review and meta-analysis
BACKGROUND: Migrant workers are increasingly recognised as a nutritionally vulnerable population due to unstable working conditions, disrupted food environments, and limited access to health services. However, global estimates of malnutrition in this group remain fragmented. We aimed to identify the global prevalence of underweight and overweight/obesity among migrant workers and identify key moderating factors. METHODS: We conducted a systematic review and meta-analysis following PRISMA guidelines. We searched seven databases without restrictions on language, region, or year of publication. Observational studies reporting the prevalence of underweight (body mass index (BMI) < 18.5 kg/m2) or overweight/obesity (BMI ≥ 25 kg/m2) among migrant workers were included. We calculated pooled prevalence estimates using generalised linear mixed models with random effects. We assessed heterogeneity with I2 and Cochran's Q statistics. Moderator analyses were conducted using meta-regression and subgroup comparisons. Further, we appraised study quality using the Joanna Briggs Institute tools, and assessed the certainty of the evidence using GRADE. RESULTS: We included 30 studies involving 135 404 migrant workers with a mean age of 32.3 years (standard deviation = 11.1). The pooled prevalence was 4.7% (95% confidence interval (CI) = 3.1, 6.9) for underweight and 43.7% (95% CI = 39.8, 47.6) for overweight/obesity, suggesting a substantial double burden of malnutrition. Underweight was more common among local migrants and in lower-middle-income settings, particularly in South Asia, whereas overweight/obesity was more common among international migrants, especially in high-income countries and in Europe and Central Asia. Moderator analyses identified female proportion, destination country or region, income level, and marital status as significant moderators for both outcomes. CONCLUSIONS: Migrant workers experience a substantial double burden of malnutrition, although the pattern varies across migration contexts. Undernutrition remains a concern in lower-income settings, whereas overweight and obesity are more common in high-income settings. Integrating nutrition-sensitive strategies into labour and migration health policies, including healthier food environments, routine nutritional screening, and culturally appropriate interventions, may help reduce health inequalities in this population. REGISTRATION: INPLASY: 202540030.
16 May 2026
Read appraisal →BMJ open
Transitioning from paper-based to electronic health management information systems in Africa: a scoping review protocol
INTRODUCTION: The rising shift from paper-based to electronic health management information systems (EHMIS) among global health systems has shown promising strides over the past decade. Yet, most African health systems have continued to use paper records with attendant gaps and challenges. Most African governments have now started transitioning from paper to EHMIS but lack adequate guidance to support this shift. There is therefore a need for harmonised regional guidance to ensure that such transitions are carried out systematically and take into account country-specific contexts. OBJECTIVE: The objective of this study protocol is to conduct a scoping review to generate evidence that will inform the development of a comprehensive guide to support countries in the WHO African Region in transitioning from paper-based to EHMIS. METHODS AND ANALYSIS: The review will follow established methodological guidance for scoping reviews as outlined by Arksey and O'Malley and further refined by Levac et al and the Joanna Briggs Institute, with reporting guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. A search strategy will be developed to systematically identify relevant studies from both published and grey literature sources including PubMed, Cochrane Library, Scopus and African Index Medicus. Other sources will include Google Scholar, Emerald Journal, the WHO Regional Office for Africa Library and websites of WHO, ITU and Ministries of Health. Reference lists of the retrieved published articles will be manually searched to identify additional relevant studies. Descriptive qualitative content analysis will be undertaken using the policy analysis framework and key findings will be summarised and presented using tables, charts and maps. ETHICS AND DISSEMINATION: This study does not involve the collection of primary data; therefore, ethical approval will not be required. On completion of the study, findings will be submitted for publication in a peer-reviewed scientific journal and will also be presented at national, regional and international conferences to support knowledge sharing and policy engagement.
16 May 2026
Read appraisal →Philosophical transactions of the Royal Society of London. Series B, Biological sciences
A meta-analysis of gut microbiome research in malnourished African populations: a natural language processing approach
Malnutrition still affects millions of children in Africa. Changes in the gut microbiome have been implicated in malnutrition, but there has been inconsistent nomenclature of microbes. This meta-analysis reviews the microbiome literature using natural language processing (NLP) methods. We searched PubMed for gut microbiome studies of undernourished children living in low- and middle-income countries (LMICs). The primary analysis focused on continental coverage and study characteristics of microbiome research in sub-Saharan Africa (ss-Africa). We also used an NLP tool for normalizing primary data from full-text publications in ss-Africa compared with other LMICs, and between diseased and healthy children. We identified 16 studies. Most studies were conducted in Malawi and characterized the faecal microbiome using 16S rRNA sequencing. For comparison, 18 studies conducted in Bangladesh, India, Pakistan and Peru were included. With this, we identified frequently reported microbes that were distinctly identified in ss-Africa and highlighted possible signatures of an undernourished faecal microbiome across the globe. The consistent associations between elevated Pseudomonadota levels and severe acute malnutrition provide new insights into host-microbiome interactions in African contexts. However, the overlap between taxa associated with healthy and stunting underscores the need for further research to better inform potential targeted interventions in Africa. This article is part of the theme issue 'Biological, biomedical and environmental drivers of stunting'.
15 May 2026
Read appraisal →BMJ global health
Integrated mass drug administration for yaws eradication: evidence from a comparative observational study in Papua New Guinea and a systematic review with network meta-analysis
BACKGROUND: Yaws is a chronic infectious disease that disproportionately affects under-reached communities. In 2023, Papua New Guinea (PNG) reported 100 165 suspected yaws cases, accounting for 45% of cases reported worldwide. The WHO targets yaws eradication by 2030, primarily through mass drug administration (MDA) of azithromycin. This study evaluates the impact of an integrated MDA programme in PNG and reviews global evidence on optimal MDA strategies through a network meta-analysis (NMA). METHODS: A comparative observational study was undertaken analysing outpatient department (OPD) attendances between West New Britain province (WNB; intervention) and New Ireland province (NIP; comparator) from November 2023 to August 2024. The intervention in WNB involved a single-round, integrated four-drug MDA provided in December 2023, comprising azithromycin, ivermectin, diethylcarbamazine and albendazole. Temporal trends in OPD attendances were analysed using negative binomial regression. A Bayesian NMA of six studies identified through a systematic review compared the effectiveness of azithromycin-based regimens for yaws eradication. RESULTS: Between Q3 2023 and Q1 2024, yaws-related OPD attendances in WNB declined significantly, with a 41% (p<0.0001) reduction relative to the comparator province (NIP). This reduction was sustained for at least 6 months following MDA. Over the same period, a 33% decline in total skin-related outpatient attendances was observed. In the NMA, three rounds of azithromycin MDA were associated with lower odds of active yaws at follow-up than observation (OR 0.04, 95% CrI 0.005 to 0.24) and had the highest probability of being ranked most effective. Single-round azithromycin MDA was also associated with reduced odds of active yaws at follow-up (OR 0.15, 95% CrI 0.05 to 0.45). CONCLUSION: In a high-burden setting, a single round of integrated MDA was associated with substantial early reductions in yaws burden. Multi-round azithromycin strategies, particularly three-round regimens, were associated with larger and more sustained reductions in community prevalence. These findings inform considerations for yaws control efforts in settings with persistent transmission.
15 May 2026
Read appraisal →Lancet (London, England)
Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
BACKGROUND: Malaria vaccines have been added to immunisation schedules in 25 sub-Saharan African countries, with the expectation that deaths in young children would be prevented. The introduction of the RTS,S/AS01E malaria vaccine (RTS,S) in Ghana, Kenya, and Malawi in 2019 was evaluated over 4 years to show the impact on mortality in young children and to monitor severe malaria admissions, vaccine uptake, and safety. Favourable evidence on safety and impact on severe malaria admissions during the first 2 years contributed to WHO's recommendations on malaria vaccines. Here, we report the primary analysis of the impact on mortality at 46 months. METHODS: Clusters of administrative units (districts in Ghana, subcounties in Kenya, and groups of immunisation clinics in Malawi), each with an estimated annual birth cohort of about 4000 children, were randomly assigned 1:1 to introduce the RTS,S malaria vaccine in 2019 (implementation areas), or to implement later (comparison areas). RTS,S was delivered in a four-dose schedule, at age 6, 7, 9, and 24 months in Ghana and Kenya, and at age 5, 6, 7, and 22 months in Malawi. Surveillance for post-neonatal mortality in children younger than 5 years was established throughout by a network of 26 000 local reporters who notified deaths in their community. The families were then visited at home by study staff to confirm details and complete a verbal autopsy. Surveillance for severe malaria and other conditions was strengthened in 18 sentinel hospitals serving part of the study area and maintained for 46 months. Uptake of RTS,S and other vaccines was monitored by the Expanded Programme on Immunisation in each country and independently through three household coverage surveys, at baseline, and at about 18 months and 30 months after introduction of RTS,S. The primary outcome of this impact evaluation was mortality due to any cause, except injury, in children eligible to receive three doses of RTS,S. Mortality rate ratios were estimated by comparing the ratio of deaths among vaccine-eligible age groups to deaths in non-eligible age groups between implementation and comparison areas. This evaluation is registered on ClinicalTrials.gov (NCT03806465) and is complete. FINDINGS: 158 clusters (66 in Ghana, 46 in Kenya, and 46 in Malawi) were selected and randomly assigned; 79 areas served as implementation areas and 79 as comparison areas. By the end of the 46-month evaluation period, 1 289 504 children had received the first dose of RTS,S, 1 158 850 had received the second dose, 1 068 039 had received a third dose, and 436 527 had received a fourth dose. Coverage assessed in 2022 was 82·8% (95% CI 80·7-84·9) for the first dose, 71·1% (68·8-73·5) for the third dose, and 39·9% (36·9-42·9) for the fourth dose. Excluding deaths due to injury, there were 5576 deaths in implementation areas versus 6152 in comparison areas in children eligible to have received the third dose of RTS,S, and 7534 versus 7044 deaths among non-eligible children. The mortality rate ratio was 0·87 (95% CI 0·77-0·97; p=0·016). INTERPRETATION: Introduction of the RTS,S malaria vaccine in routine immunisation programmes was associated with a significant reduction in mortality in young children, averting about one in eight deaths, in areas with moderate coverage of three doses of the vaccine and low uptake of the fourth dose. These results highlight the urgency to accelerate the deployment of malaria vaccines in areas of Africa where malaria continues to be a leading cause of child mortality. FUNDING: WHO; Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and Unitaid. TRANSLATIONS: For the French translation of the abstract see Supplementary Materials section.
13 May 2026
Read appraisal →Vaccine
Factors affecting human papillomavirus vaccination: A review of individual, interpersonal, and structural factors affecting vaccine uptake among adolescents.
BACKGROUND: Human papillomavirus (HPV) related cancers, particularly cervical cancer, remain a major public health challenge in low- and lower-middle-income countries (LLMICs), which bear a disproportionate share of global HPV-attributable mortality. Despite the availability of safe and effective vaccines for nearly two decades, vaccination coverage remains low in LLMICs. Several barriers ranging from health misinformation to systemic delivery challenges have hindered efforts to scale up vaccination programs in these settings. OBJECTIVES: This systematic review aims to identify and synthesize the behavioral and structural factors influencing HPV vaccine uptake among adolescents in LLMICs. Guided by a multi-level behavioral health framework, findings were categorized across: individual, interpersonal, and structural domains. METHODS: A comprehensive search of seven databases identified 639 records, of which 34 empirical studies met inclusion criteria. Eligible studies focused on HPV vaccination uptake among adolescents in World Bank-defined LLMICs and were assessed for thematic relevance. Data extraction emphasized barriers and facilitators to uptake. RESULTS: Individual-level barriers included limited awareness, misconceptions about HPV and the vaccine, and fear of side effects. Interpersonal dynamics-particularly parental consent, gendered norms, and community endorsement-shaped adolescent vaccine decision-making. Structural barriers included vaccine stock-outs, weak delivery infrastructure, and limited reach among out-of-school youth. School-based delivery models, trusted healthcare workers, and community sensitization emerged as key facilitators. CONCLUSIONS: Improving HPV vaccine coverage in LLMICs requires coordinated, multi-level interventions that simultaneously address behavioral and structural determinants. Findings highlight the critical role of community engagement, flexible delivery models, and long-term sustainability planning to ensure effective implementation. These insights have direct implications for national immunization policy, health system strengthening, and achievement of global cervical cancer elimination targets in resource-limited settings. Tailoring implementation to the contextual realities of LLMICs will be essential to advancing equity in HPV-related cancer prevention.
13 May 2026
Read appraisal →BMJ open respiratory research
Prevalence and determinants of drug-resistant pulmonary tuberculosis in the MENA region: a systematic review and meta-analysis
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a constraining challenge for tuberculosis (TB) control worldwide. The Middle East and North African (MENA) region represents a significant part of the global MDR-TB burden. AIM: To estimate the pooled prevalence of MDR-TB and its determinants in the MENA region. METHODS: We searched for studies published in English and French on the subject up to 31 January 2026 on Web of Science, PubMed, Scopus and Cochrane, without time restriction. Original studies reporting data on the prevalence of MDR-TB in individuals living in the MENA region were selected. The meta-analysis was done using the random effects model considering the heterogeneity among the included studies and I 2 statistic was used to assess the heterogeneity. RESULTS: A total of 1239 articles were identified and 25 studies from 6 countries were included in this review. The prevalence of MDR-TB in the MENA region ranged from 0% (95% CI 0% to 4.1%) to 17.1% (95% CI 10.6% to 25.4%). The pooled prevalence was 3.54% (95% CI 2.18% to 5.72%) with a high heterogeneity, I2 =95.6%; 95% CI 94.4% to 96.5%. Previous exposition to TB treatment, HIV infection, smoking and the presence of comorbidities were the most reported associated factors. CONCLUSION: This review underscores the persistence of MDR-TB in the MENA region, suggesting insufficiency in TB control. Multisectoral interventions integrating strong prevention measures, standardised treatment protocols and measures to enhance treatment adherence should be implemented.
12 May 2026
Read appraisal →International health
Neglected tropical diseases in conflict-related humanitarian emergency settings: a systematic review of the literature
Neglected tropical diseases (NTDs) are a group of 21 conditions affecting an estimated 1 billion people worldwide, causing significant mortality and morbidity. WHO has targeted their control, elimination or eradication by 2030, while highlighting that conflict and humanitarian emergencies are risks to achieving this. A systematic review of peer-reviewed literature was undertaken, using terms related to conflict-related humanitarian emergencies (CRHE), based on the Armed Conflict Location & Event Data Project codebook terms for defining emergencies and terms including all WHO-defined NTDs. After a two-stage screening process, 26 papers were included. Common challenges for NTD programmes in CRHE were healthcare access, infrastructure, population movement and data quality. Multisectoral collaboration between actors in conflict-settings was offered as a learning for NTD programmes, along with community participation and decentralisation. Evidence gaps were identified in the knowledge base for certain NTDs and in high-quality evidence for interventions in CRHE. Collaboration is a key area for focused improvement for NTD programmes in CRHE. This should be across sectors and extend to research and analysis approaches, to ensure the most effective interventions are identified and implemented and that NTD road map targets can be achieved.
12 May 2026
Read appraisal →International health
Systematic narrative review on Menstrual health and hygiene (MHH) in Nigeria, Ghana, Liberia and The Gambia
Menstrual health and hygiene (MHH) are critical components of women's well-being, yet they continue to be overlooked in many low-resource settings. Addressing MHH issues in West Africa is crucial due to their widespread impact on education, health and gender equality, particularly among adolescent girls and women of reproductive age. This systematic narrative review consolidates the existing literature on MHH practices, knowledge, barriers and interventions in Nigeria, Ghana, Liberia and The Gambia. A comprehensive search was conducted across four databases (PubMed, Scopus, CINAHL Plus and Africa Journals Online) for studies published from 2000 to 2024. The search terms were related to menstruation, hygiene and the four West African countries. Both peer-reviewed articles and grey literature (Google Scholar, policy documents) were included to capture a broad spectrum of findings. Studies were selected based on their relevance to MHH in the target countries and data were extracted and analysed thematically. Of 345 articles identified, 26 studies met the inclusion criteria. Key findings highlighted the widespread lack of adequate MHM resources, such as sanitary products and functional sanitation facilities. Socio-economic disparities, cultural stigma and insufficient educational resources were major barriers to effective MHM. The review also found a strong link between inadequate MHM and adverse outcomes, including school absenteeism, psychological distress and increased vulnerability to infections. This review underscores the pressing need for comprehensive interventions to address MHH as a public health and human rights issue in Nigeria, Ghana, Liberia and The Gambia. Ensuring access to sanitary products, improved sanitation facilities and robust educational programs can help empower girls and women to manage menstruation with dignity, thereby improving their health, education and social participation.
12 May 2026
Read appraisal →International journal of biometeorology
Recent trajectories of biometeorology in the Global South: a systematic review of biometeorology research in the International Journal of Biometeorology
Literature reviews have become increasingly prominent in scientific discourse; however, few have critically examined the geographic distribution of research, particularly in the field of biometeorology, where studies remain disproportionately concentrated in the Global North. Building on previous regional reviews and special issues, this paper critically examines geographic disparities in publication trends, authorship, and methodological approaches to aid in identifying challenges and opportunities for equitable and justified future research. Using a PRISMA-style framework, 591 empirical studies conducted across 147 Global South countries were identified from a total of 3,046 publications in the International Journal of Biometeorology (IJBM) between 2000 and 2024. The review reveals a steady increase in contributions from the Global South over time, but highlights persistent gaps in representation, especially in author affiliation and research leadership. Thematic and methodological analyses highlight the diversity and innovation present in Global South contexts, while also revealing structural barriers to equitable participation in the field. This work advocates for more inclusive research practices and enhanced institutional support to bridge the divide between the Global North and South, fostering a more representative and collaborative future for biometeorology.
12 May 2026
Read appraisal →Journal of global health
The effectiveness and cost-effectiveness of cash plus interventions to prevent acute malnutrition in Somalia: evidence from an adaptive cluster randomised control trial
BACKGROUND: Acute malnutrition affects millions of children aged <5 years, as well as pregnant and lactating women globally, especially in humanitarian settings. Although cash plus interventions - cash or food transfers combined with complementary components - are widely implemented, evidence remains limited on which combinations and durations are most effective at preventing acute malnutrition. METHODS: We conducted a three-arm cluster-randomised trial within the 'Save the Children's Cash Plus for Nutrition' programme in Somalia. Monthly support was provided as cash alone (arm 1), cash plus social and behaviour change communication (arm 2), or cash plus an additional cash top-up (arm 3). Further, we randomised 33 villages across arms, targeting approximately 1500 households. Primary outcomes included the prevalence and incidence of acute malnutrition in children aged 6-59 months and in mothers, assessed at baseline, midline (three months), and endline (six months). We also conducted market monitoring, qualitative data collection, and analysis. RESULTS: Child acute malnutrition prevalence was approximately 15.0% in each arm at baseline. After three months, prevalence declined by 2.0 percentage points in arm 1 to 13.0% (95% confidence interval (CI) = 10.3, 16.1), representing a relative reduction of 13.3%. In arm 2, prevalence declined by 5.9 percentage points to 9.1% (95% CI = 6.8, 11.8), a relative reduction of 39.3%. In contrast, prevalence in arm 3 remained essentially unchanged, increasing to 15.1% (95% CI = 12.1, 18.6). By endline, there was little change from midline in all arms. Maternal malnutrition improved most in arm 2, but differences were not statistically significant. All arms showed improvements in dietary diversity and food security, but only arm 2 achieved sustained nutrition gains. Household livelihood conditions appeared to improve overall, though monthly expenditures nearly doubled. Arm 2 was the most effective and cost-effective. CONCLUSIONS: Adding social and behaviour change communication to cash transfers significantly improved child nutrition compared to cash alone, highlighting that integrated approaches can enhance nutritional outcomes and at minimal additional cost in humanitarian settings. REGISTRATION: ClinicalTrials.gov: NCT06642012.
12 May 2026
Read appraisal →International health
Atopic dermatitis in Ethiopia: a systematic review and meta-analysis
Despite being a leading contributor to the global burden of skin disease there is no information on the national prevalence of atopic dermatitis in Ethiopia. Therefore, the purpose of this systematic review and meta-analysis was to estimate the pooled national prevalence of atopic dermatitis in Ethiopia. A computerized systematic search using multiple databases was performed in search of relevant English articles from the inception of the databases to 30 July 2023. It was done in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis (i.e. PRISMA) standard. R and R Studio software were used for statistical analysis. A random-effects model was used for calculating the pooled estimate of the prevalence of atopic dermatitis. Forest plots and tables were used to represent the data. We found 10 full-text observational studies with 25 920 participants suitable for the review after checking for inclusion and exclusion criteria. The overall pooled prevalence of atopic dermatitis in Ethiopia was 12.75% (95% CI 8.32 to 17.17%). The subgroup analysis found that the atopic dermatitis pooled prevalence was 7% (95% CI 3 to 10%), 17% (95% CI 4 to 30%) and 20% (95% CI 15 to 24%) in the Oromia region, Amhara region and Addis Ababa city administration, respectively. This study demonstrates that atopic dermatitis is highly prevalent in Ethiopia, affecting approximately one in eight individuals, with significant geographical variations. To effectively address this condition, it is crucial to implement awareness campaigns, prioritize specialized training for healthcare professionals, allocate resources to high-prevalence areas, establish a national registry for monitoring, develop community support programs and encourage further research, as there are currently few studies on the condition.
11 May 2026
Read appraisal →International health
Pneumonia in Ghana: prevalence, mortality and antimicrobial resistance-a systematic review and meta-analysis
Pneumonia is a major cause of morbidity and mortality in Ghana, especially among children <5 y of age and the elderly. However, comprehensive data on its prevalence and distribution remain limited. This systematic review addresses this gap by analysing the prevalence, regional variations, risk factors, antimicrobial resistance and mortality rates of pneumonia in Ghana. We searched PubMed, ScienceDirect, Web of Science and African Journals Online databases, including 21 studies with a total of 124 582 participants. A random-effects meta-analysis estimated pooled prevalence and subgroup differences based on age, region and participant type. Heterogeneity was assessed using the I2 test and meta-regression, with sensitivity analysis also conducted. Study quality was evaluated using standardized Joana Briggs Institute checklists for prevalence studies. The pooled prevalence of pneumonia in Ghana was 22.01%, with significant regional variations. The highest prevalence was observed in a study conducted in the Greater Accra and Northern regions (32.31%), while the lowest was in the Upper West (4.83%). The prevalence in children <5 y of age was 17.79%. Hospitalized patients had a higher prevalence (22.14%) than community children (21.49%). Streptococcus pneumoniae was the most common pathogen, with high resistance (>70%) to co-trimoxazole, gentamicin and tetracycline. Key risk factors included indoor air pollution and seasonal changes. The mortality rate for pneumonia was found to be 3.07%. This systematic review highlighted significant regional disparities, pathogen resistance patterns and environmental risk factors that shape the burden of pneumonia in Ghana, providing critical evidence for targeted public health strategies. The findings highlight avenues for future research, including environmental drivers of transmission, focusing on underreported regions and surveillance of antibiotic resistance of pathogens isolated from pneumonia patients.
11 May 2026
Read appraisal →European journal of pediatrics
Prognosis of neonates receiving invasive mechanical ventilation in low-resource settings: a systematic review and prognostic meta-analysis
Provision of invasive mechanical ventilation (IMV) in the neonatal intensive care has seen a steady rise in low-esource settings (LRS). However, outcomes among those exposed to IMV remain under-reported, with the current evidence base being restricted to single-centre observational studies, thus limiting comparative analyses and effective healthcare planning. This study aims to estimate the pooled proportion of mortality and morbidity among neonates exposed to IMV in low-resource settings. Medline, Embase, and CENTRAL were searched until 22 August 2025. Randomised and non-randomised studies were included. Two reviewers, blinded to each other, extracted data independently. Proportion-based meta-analyses using random-effects model were performed. Risk of bias was assessed using ROBINS-E, and evidence-certainty was evaluated using the GRADE approach. One hundred of 117 studies were included, with most conducted in South Asia. In-hospital mortality was reported in 68 studies (7193 neonates), with a pooled estimate of 45% (39%-50%), evidence-certainty being very low. Among the secondary outcomes, the pooled rates were as follows: bronchopulmonary dysplasia, 10% (5%-18%); intraventricular haemorrhage (any grade), 10% (5%-19%); necrotising enterocolitis (any stage), 14% (6%-31%); retinopathy of prematurity (any stage), 33% (22%-46%); ventilator-associated pneumonia, 21% (14%-29%); sepsis, 32% (25%-40%) and pulmonary haemorrhage, 9% (6%-14%). Evidence-certainty for all the secondary outcomes was also very low. Subgroup analysis comparing two distinct time epochs revealed a significant difference in mortality, 43% (36%-50%) (I2 = 93.5%) in the post-2010 epoch compared to 55% (48%-63%) (I2 = 82.9%) in the pre-2010 epoch (p = 0.004). Heterogeneous outcome definitions and predominance of unadjusted analyses across studies limit the existing evidence.Conclusions: In LRS, the mortality and morbidity rates among neonates receiving IMV remain substantially high with a modest improvement in survival in the past decade. Improving outcomes mandates moving beyond access to the provision of IMV to investing in comprehensive training and scaling up critical auxiliary resources. Future research must adopt standardised outcome definitions and adjusted analyses to precisely quantify the impact of IMV in LRS.
11 May 2026
Read appraisal →Transactions of the Royal Society of Tropical Medicine and Hygiene
Quality of life in Indian people affected by leprosy? A systematic review from the country with the highest burden of leprosy cases.
Quality of life (QoL) is important for people with leprosy since the disease can cause physical and psychological problems. These problems may result in stigma and social discrimination. India reported 107 851 new leprosy cases for the year 2023-24, accounting for 61.6% of new cases detected globally. This systematic review was conducted to assess the QoL among people affected by leprosy in India using existing literature. The Scopus, PubMed and Infolep databases were searched for articles for this systematic review and included only studies conducted in India. The critical appraisal tool of cross-sectional studies (AXIS) was used to assess the study quality and risk of bias. The search identified 253 articles. After screening titles and abstracts, 23 full-text articles were assessed for eligibility and 12 studies were included in the systematic review. The World Health Organization Quality of Life-Bref instrument was used to measure QoL. Of the 12 studies, the factors of disability (9 studies) and old age (8 studies) were highly associated with low levels of QoL. Five studies identified that low levels of QoL are associated with being female with the leprosy. Early identification and prevention of disabilities are important steps in improving the QoL. Increased investment is needed in leprosy programmatic activities and research to achieve the target of zero leprosy.
10 May 2026
Read appraisal →BMJ health & care informatics
i-MoMCARE: AI-enabled mobile app for maternal and child health care in Cambodia - a pilot implementation and evaluation study
OBJECTIVES: In Cambodia, village health support groups (VHSGs) are central to maternal and child health (MCH) service delivery, yet maternal mortality remains high with regional disparities. Although digital health solutions show promise, their real-world use is underexplored. This study therefore aims to evaluate the i-MoMCARE app in supporting VHSGs and health centre staff for delivering MCH services. METHODS: A mixed-methods approach guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework was used. Reach was assessed using programme records (number of users trained and MCH cases managed). Effectiveness and adoption were evaluated using the mHealth App Usability Questionnaire (MAUQ) and qualitative data on user experience and intention to use. Implementation was examined through system usage monitoring and feedback on workflow integration. Maintenance was explored using qualitative insights on long-term use, barriers and recommendations. RESULTS: 44 VHSGs and 10 health centre staff were trained, and 96 MCH cases were managed with the app. Usefulness was rated highly (MAUQ 5.58, SD 1.04), with users appreciating the user-centric design that improved usability and integration into daily workflows. Effectiveness was similarly high (MAUQ 5.50, SD 0.95); the clinical decision support system and point-of-care alerts were valued as reliable decision-support tools, and the electronic medical record (EMR) was seen as a secure data repository. However, adoption was hindered by hardware and software limitations (MAUQ 5.79, SD 0.75), including device availability and low digital literacy. DISCUSSION: Our findings highlight the value of the i-MoMCARE app in supporting VHSGs, particularly those with limited training, by enhancing their decision-making. The study also lays the groundwork for a unified EMR in primary care. However, concerns around hardware and software limitations hinder adoption and sustained use. CONCLUSION: To enable scale-up, we recommend reducing access barriers and supporting sustained use through diversifying the platform's design and implementing phased incentivisation strategies.
27 Apr 2026
Read appraisal →PloS one
Protocol for a randomized pilot trial of COMPASS, an open‑source, culturally adapted cognitive behavioral therapy program for forcibly displaced Venezuelan adults in Peru
Task-sharing approaches have shown promise in low-resource settings, yet few culturally adapted interventions have been systematically evaluated for forcibly displaced populations. Since 2016, over 1.7 million Venezuelans have migrated to Peru, facing significant barriers to healthcare and elevated risks of anxiety, depression, and post-traumatic stress disorder (PTSD). This protocol describes COMPASS (Cognitive-behavioral Open-source Mental-health Program Adapted for migrants, Sustainably delivered by lay providers and Supported by evidence). COMPASS is a transdiagnostic, open-source cognitive behavioral therapy program co-designed with forcibly displaced populations. This protocol describes the procedures for an ongoing randomized pilot trial with n = 90 forcibly displaced Venezuelan people (Clinicaltrials.gov: NCT06635486). COMPASS guides, or lay providers, trained through an intensive apprenticeship model, will deliver 6-12 weekly remote sessions. Primary outcomes include changes in anxiety, depression, and PTSD symptoms, assessed with validated Spanish-language measures. Secondary outcomes include feasibility (recruitment, retention, fidelity) and acceptability (therapist and participant ratings). Exploratory outcomes will examine integration, migration experiences, and demographic moderators of intervention effectiveness. Analyses will follow the intention-to-treat principle, using descriptive statistics and regression models to evaluate symptom trajectories across baseline, post-intervention, and 3- and 6-month follow-ups. This study represents the first effectiveness evaluation of an open-source, lay-delivered CBT program tailored for forcibly displaced people in Peru. Findings will inform feasibility, acceptability, and preliminary effectiveness of COMPASS, with potential to expand scalable, culturally relevant mental health services for forcibly displaced populations in resource-constrained settings worldwide.
27 Apr 2026
Read appraisal →American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Tech That Scales: A Practical Framework for Artificial Intelligence-Enabled Cancer Care in Low- and Middle-Income Countries and Underserved US Counties
Cancer outcomes remain starkly unequal: 5-year survival rates for common malignancies in low- and middle-income countries (LMICs) often lag 20-40 percentage points behind high-income benchmarks, and similar disparities persist between well-resourced metropolitan centers and rural or safety-net settings within high-income countries. The gap is driven less by the absence of effective interventions than by workforce shortages, fragmented referral pathways, limited infrastructure, and loss to follow-up after abnormal screens. Technologies that scale must therefore function as deployable workflows integrating staffing, logistics, quality assurance (QA), governance, and monitoring not merely as stand-alone algorithms or devices.1 This review synthesizes evidence across four complementary technology families that address these constraints across the continuum of care: artificial intelligence (AI)-supported screening and triage as the population entry-point layer; Project ECHO telementoring as the workforce-capacity layer; electronic patient-reported outcomes and remote symptom monitoring as the longitudinal continuity layer; and AI-powered clinical trial prescreening hubs as the access-to-innovation layer. The technologies do not carry equal evidentiary weight, and they should not be deployed identically in every setting. Our aim is to show how oncology leaders can sequence them pragmatically inside a common operating logic while adapting to local infrastructure and governance. We organize the framework in patient journey order entry into care through screening, workforce support through telementoring, continuity through remote monitoring, and access to innovation through trial prescreening, and draw examples from both LMIC programs and underserved US settings. We therefore present a practical implementation playbook, including a 90-day launch checklist, staffing models, QA frameworks, equity and bias monitoring metrics, and a program outcomes dashboard designed for oncology leaders seeking to move beyond pilots toward durable, monitored deployment.
27 Apr 2026
Read appraisal →BMJ health & care informatics
Barriers associated with the implementation, adoption, scale-up and sustainability of mHealth in Sub-Saharan Africa: a systematic review guided by the NASSS Framework
OBJECTIVES: The objectives of this study were to highlight and evaluate the factors affecting the non-adoption, abandonment of and challenges to scale-up, spread and sustainability of mHealth in Sub-Saharan Africa (SSA) and to assess the appropriateness of the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability (NASSS) Framework in the SSA context. METHODS: A systematic search of published research was conducted using PubMed and Embase research databases from 2012 to 2025. Peer-reviewed studies from SSA countries, evaluating mHealth interventions, were included in this study. Papers were analysed to identify barriers according to the seven domains of the NASSS Framework, which are (1) condition, (2) technology, (3) value proposition, (4) adopters, (5) organisation(s), (6) wider system, (7) embedding and adaptation over time RESULTS: This study identified 409 barriers across 91 papers. 309 barriers were covered by the seven NASSS Framework domains, while 100 were unaddressed by the framework. The main barriers were associated with domain 2, the technical aspects of the technology (27%). Other prominent barriers related to the wider system (18%), the adopter (11%), the organisation (9%) or condition (8%), with the value proposition (1%) and embedding and adaptation over time (1%), least hindering implementation. Challenges which were unaddressed by the framework (24%) included socioeconomic and infrastructural issues, distinct to lower and middle-income countries (LMIC). DISCUSSION: This paper highlights the importance of evaluating rudimentary aspects of mHealth and preparing infrastructure before addressing more complex issues during mHealth implementation in SSA. CONCLUSION: Although the NASSS Framework is applicable to the SSA region, it would benefit from some further development to improve its applicability in LMICs.
25 Apr 2026
Read appraisal →Journal of the American College of Cardiology
African Representation in Randomized Controlled Trials Published in Leading Medical and Cardiovascular Journals, 2019-2024
BACKGROUND: Despite accounting for a substantial proportion of the global population and disease burden, African countries are underrepresented in randomized controlled trials (RCTs), including those informing cardiovascular (CV) care. OBJECTIVES: In this study, we sought to quantify African representation in RCTs published from 2019 to 2024 in: 1) 5 leading general medical journals; and 2) 3 leading CV journals. METHODS: We conducted a systematic review of RCTs published from 2019 to 2024 in the British Medical Journal, the Journal of the American Medical Association, The Lancet, Nature Medicine, and the New England Journal of Medicine, and in Circulation, the European Heart Journal, and the Journal of the American College of Cardiology. Eligible studies included traditional, pragmatic, cluster, and stepped-wedge RCTs. African representation was assessed by trial scope (Africa-only vs multicontinental), country and regional participation, disease category, and African authorship. RESULTS: Among 2,138 RCTs published in leading general medical journals, only 83 (3.9%) were conducted exclusively in Africa, and 195 (9.1%) were multicontinental studies including at least 1 African site. In the CV journals, 2 out of 334 RCTs (0.6%) were conducted exclusively in Africa, and African sites were included in only 9 multicontinental trials (2.7%). South Africa accounted for the majority of Africa-based RCTs across both journal categories. Regionally, southern Africa predominated and central Africa was minimally represented. Trials published in general medical journals and conducted exclusively in Africa largely focused on infectious diseases (n = 63; 75.9%), with only 3 addressing cardiovascular disease (CVD). In contrast, Africa-including multicontinental trials more frequently investigated noncommunicable diseases, including CVD. African leadership was common in Africa-only trials but rare in multicontinental studies. CONCLUSIONS: African countries are profoundly underrepresented in RCTs published in the world's most influential medical and CV journals. Addressing this imbalance requires expanding African participation in global trials, investing in local research capacity, and promoting equitable leadership to strengthen the relevance and validity of clinical evidence. (Underrepresentation of African Countries in Randomized Controlled Trials: A Systematic Review of Leading General Medical and Cardiovascular Journals; CRD42024603157).
24 Apr 2026
Read appraisal →PloS one
Forecasting under-five stunting in Ethiopia using classical and machine learning time series models
BACKGROUND: The prevalence of under-five stunting in Ethiopia remains above 30%, which, according to World Health Organization (WHO), constitutes a major public health concern. Stunting has long-term consequences for child growth, development, and overall health. Accurate forecasting of its prevalence is therefore essential to guide policymakers and inform targeted interventions. This study aimed to forecast the prevalence of under-five stunting in Ethiopia for the period 2025-2030 using historical data and time series modeling. METHODS: Annual under-five stunting prevalence data for Ethiopia from 2000 to 2024 were retrieved from the WHO Global Health Observatory. Time series forecasting models, including Autoregressive Integrated Moving Average (ARIMA), Exponential Smoothing (ETS), Multilayer Perceptron (MLP), and Long Short-Term Memory (LSTM), were developed and evaluated. Model performance was assessed using time series cross-validation with mean absolute error (MAE), mean absolute percentage error (MAPE), and R² as evaluation metrics. The best-performing model was applied to forecast stunting prevalence for 2025-2030. RESULTS: The ETS model demonstrated the best predictive performance (MAE = 1.09, MAPE = 2.71%, R² = 0.903) and was selected for forecasting. Forecasting indicated a gradual decline in under-five stunting prevalence in Ethiopia from 33.95% in 2025 to 31.95% in 2030. The projected prevalence for 2029 is 32.35% (95% CI: 26.90-37.79%), above the national target of 19%, and the 2030 forecast remains well above the SDG target of ending all forms of malnutrition. CONCLUSION AND RECOMMENDATION: Under-five stunting in Ethiopia is projected to remain above national and SDG targets by 2030, indicating current nutrition efforts are insufficient; national program evaluation and evidence-based policy adjustments are recommended.
24 Apr 2026
Read appraisal →Medicine
Trends and determinants of tuberculosis incidence in Turkey: A secondary data analysis
Tuberculosis remains a major public health concern, with incidence rates influenced by social determinants of health. Although tuberculosis incidence in Turkey has declined markedly in recent decades, the factors associated with this decline have not been comprehensively evaluated at the country-level. This study aimed to examine trends in tuberculosis incidence in Turkey from 1982 to 2021 and to identify determinants of tuberculosis incidence rates between 2000 and 2021, considering variables categorized under composite development, economic indicators, population, and health services. A longitudinal ecological study was conducted using secondary data to examine trends and determinants of tuberculosis incidence in Turkey. Univariate and multivariable linear regression were employed to evaluate the associations between tuberculosis incidence rates and 10 selected variables. Tuberculosis incidence in Turkey declined substantially over the 40-year period analyzed, with an overall decrease of 86.6% and sharper reductions observed in certain intervals. In multivariable linear regression, only the Human Development Index remained independently associated with tuberculosis incidence (β = -1.041, P < .001), indicating that higher Human Development Index values were associated with lower tuberculosis incidence rates in Turkey. These findings indicate that tuberculosis incidence in Turkey has declined alongside changes in human development, as reflected by the composite Human Development Index.
20 Apr 2026
Read appraisal →PloS one
Uptake and determinants of immediate and extended postpartum long-acting reversible contraceptive use in Eastern and Western Africa: A systematic review and meta-analysis
BACKGROUND: Reducing unintended pregnancies and improving maternal/child health relies heavily on postpartum family planning (PPFP). Despite their high effectiveness, the use of long-acting reversible contraceptives (LARC), such as intrauterine contraceptive device (IUCD) and implants, is inconsistent in Africa after childbirth. This systematic review and meta-analysis aimed to assess the prevalence and determinants of immediate and extended postpartum use of long-acting reversible contraceptives in Eastern and Western Africa. METHODS: We searched PubMed, the Cochrane Library, Hinari, and gray literature sources (Google Scholar) for studies published between January 1, 2015, and December 12, 2025. Eligible studies reported LARC uptake within 12 months of postpartum. Heterogeneity was assessed using the I² statistic, publication bias using Egger's test, and study quality using the JBI 2020 checklist. Data were analyzed using Stata version 17 and R version 4.5. RESULTS: Sixty-eight studies were included, most of which were from Eastern Africa. The pooled prevalence was 21.7% for immediate postpartum LARC (IPP-LARC) and 19.5% for extended postpartum LARC (EPP-LARC). Uptake was significantly associated with counseling during maternal and child health visits, partner involvement, prior family planning use, and good knowledge. Age ≥ 35 years and higher education level also favored immediate postpartum IUD use. CONCLUSION: The uptake of postpartum LARCs remains low in Eastern and Western Africa. Strengthening FP counseling during MCH services, encouraging partner involvement, and improving knowledge are critical strategies to increase coverage and reduce unmet needs. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews (ID: CRD420250577642).
19 Apr 2026
Read appraisal →Water research
Representation of urban and rural contexts in the application of wastewater surveillance for antimicrobial resistance: A systematic review.
Wastewater surveillance (WWS) can reveal community health trends through targeted monitoring of sewage. Given concerns regarding the global dissemination of drug-resistant infections, there is growing integration of antimicrobial resistance (AMR) in WWS infrastructure. However, most WWS has focused on highly urbanized sewersheds in resource-rich areas, which may exacerbate disparities in disease burdens and clinical datasets. This work presents both a systematic and scoping review of current published WWS efforts targeting antimicrobial resistance (AMR), with the aim to quantify and compare applied monitoring efforts capturing rural vs. urban areas and lower-income vs. higher-income countries. Of the 2,873 deduplicated manuscripts identified through a systematic search of four databases, 454 examined untreated domestic sewage and were characterized via a brief scoping review. Of these, 48 articles included an explicit focus on monitoring for population health surveillance, and were subject to methodological data extraction and risk of bias assessment. Sampling trends observed in the scoping and systematic review were similar. Only 13-19 % of scoping review sampling sites were classified as rural, and 44 % were located within lower- or middle-income countries (LMICs). Few articles examined AMR within unsewered communities. While analytical methods were similar across income brackets, rural monitoring efforts were more reliant on culture-based techniques than urban efforts. Monitoring in rural sites and LMICs were typically part of multi-site campaigns and featured less longitudinal sampling. Overall, methodological inconsistencies rendered a meta-analysis infeasible. The combined lack of research in rural and low-income areas indicates that key at-risk communities for circulation of AMR are an oversight.
17 Apr 2026
Read appraisal →PloS one
Virologic suppression among HIV-positive pregnant and lactating women receiving antiretroviral therapy in Africa: A systematic review and meta-analysis
BACKGROUND: The elimination of mother-to-child transmission of human immunodeficiency virus (HIV) is a key global public health priority. In Africa, virologic failure among people living with HIV continues to pose a significant public health challenge, affecting both individual well-being and community health. Maintaining viral load suppression is crucial to prevent vertical transmission of HIV and to minimize maternal morbidity and mortality. To stop the vertical transmission of HIV and lower the risk of maternal morbidity and mortality, it is important to achieve viral load suppression. Although many African countries have adopted the global 95-95-95 targets, comprehensive data on virologic suppression among pregnant and lactating mothers across the continent remains limited. The objective of this systematic review and meta-analysis was to determine the pooled estimate of virologic suppression and to examine the factors associated with it among HIV-positive pregnant and lactating women on antiretroviral therapy in Africa. METHODS: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD420251186121). We carried out a thorough systematic review by examining PubMed, ScienceDirect, Hinari, and Google Scholar for relevant studies. Data from the studies were retrieved using an Excel sheet and analyzed with STATA version 17. The Joanna Briggs Institute appraisal tool was used to evaluate the methodological quality of studies. A random-effects model with restricted maximum likelihood (REML) was applied to determine the pooled prevalence of virologic suppression (viral load threshold ≤1000 copies/ml) among pregnant and lactating mothers in Africa. A funnel plot and the Egger's test were used to investigate publication bias. Statistical heterogeneity was assessed using the I2 statistic and Cochrane's Q test. RESULTS: A total of 55 eligible studies, comprising 304,883 participants, were included in the quantitative meta-analysis. Accordingly, the overall prevalence of virologic suppression among HIV-positive pregnant and breastfeeding women in Africa was 80.86% (95% CI: 77.63%, 84.09%, I2 = 99.84%). In contrast, the pooled estimate for achieving an undetectable viral load was substantially lower, at 60.92% (95% CI: 52.46%, 69.39%; I2 = 99.91%). Virologic suppression was significantly associated with women's age (15-24 years) (AOR = 0.49; 95% CI: 0.32-0.77), disclosure of HIV status to a partner (AOR = 1.66; 95% CI: 1.31-2.11), first-line antiretroviral therapy regimen (AOR = 6.53; 95% CI: 1.93-22.06), and good antiretroviral drug adherence (AOR = 3.61; 95% CI: 1.18-11.02). In addition, other socio-demographic variables, higher educational level, being married/cohabitant, urban residency, healthcare utilization (time of ANC booking, time of ART initiation, duration of ART), fear of stigma, distance to health facility, shortage of health professionals, ART drug stock-out, and lack of HIV care commodities were significantly associated with virologic suppression among HIV-positive pregnant and lactating women in Africa. CONCLUSION: The pooled estimate of virologic suppression among HIV-positive pregnant and breastfeeding women in Africa was approximately 81%, below the global target of 95% virological suppression. This emphasizes the necessity of targeted strategies for younger HIV-positive women, disclosing HIV status, initiating first-line antiretroviral regimens, and promoting antiretroviral treatment adherence. Upgrading health care systems to enable regular viral load monitoring, as well as addressing socio-demographic and antiretroviral therapy-related variables, are vital steps towards attaining and sustaining VS in these groups of population, ultimately assisting in achieving elimination of MTCT of HIV.
14 Apr 2026
Read appraisal →BMJ paediatrics open
Systematic review of the evidence of cardiac dysfunction and intravenous fluid use among children with severe acute malnutrition and severe dehydration
BACKGROUND: A sizeable proportion of cholera attributed mortality occurs among children with severe acute malnutrition (SAM). International guidelines severely limit the use of intravenous fluids among children with SAM and cholera due to their perceived vulnerability to fluid overload. We reviewed the cardiac function evidence and studies of intravenous fluid use among children with SAM. METHODS: Two systematic reviews of Chinese, English, French and Spanish language papers published after the last Global Task Force for Cholera Control recommendations on the treatment of children with cholera and SAM (2017) were conducted. The first included studies of cardiac function among children presenting to hospital with SAM. The second included studies of intravenous fluid use among children with dehydrating diarrhoea and SAM. RESULTS: Among eight echocardiographic studies of cardiac function in children with SAM at presentation to hospital, all found left ventricular mass to be decreased but none found systolic function to be impaired. Seven of the eight studies assessing diastolic function found some degree of mild-to-moderate impairment. Two echocardiographic studies monitored responsiveness to intravenous fluid resuscitation and found no evidence of fluid overload. Finally, four studies gave intravenous fluids to children with SAM and either shock or dehydration. Collectively, these studies included 251 children with SAM given intravenous fluid. No cases of fluid overload were observed. CONCLUSION: No evidence to support decreased systolic function among children with SAM and no documented cases of fluid overload during intravenous rehydration of these children were identified. These data call into question guidelines that severely restrict intravenous fluids among children with SAM and highly dehydrating conditions such as cholera.
12 Apr 2026
Read appraisal →Proceedings. Biological sciences
Statistical structure and the evolution of languages.
Human cultural development is marked by the emergence of new words and ideas, reflecting societal changes. But how does this evolution proceed? We use modern methods in natural language processing (namely, word embeddings) to measure statistical traces of cultural development, providing a testing ground to compare different models as to how this process works. We show that real embeddings of English and 21 other languages exhibit a series of previously unrecognized regularities. Specifically, these are: (i) frequency assortativity, where entities of high popularity cluster near other high-popularity entities; (ii) characteristic clustering velocity profiles due to aggregation into hierarchical structures; (iii) persistent temporal dynamics, where newly created entities appear disproportionately near other recent entries; and (iv) Taylor's law, implying that over time and across empirical semantic space the variance in new entity counts scales as a power of the mean, which helps systematize and quantify large historical fluctuations of neologisms. To explain these facts, we propose a class of generative models (specifically, directed preferential placement) that construct synthetic embeddings exhibiting similar regularities. We show that analogous regularities also occur in other datasets, suggesting that such generating models may shed light on new aspects of language and cultural evolution.
11 Apr 2026
Read appraisal →Sexual health
Resilience of STI service delivery in community-based organizations during the 2024 armed conflict: insights from Lebanon.
This study explores the potential impact of war on STI services in Lebanon. Programmatic STI service data from Lebanon were analyzed, alongside a targeted review of the literature on conflict-affected settings, using public health databases covering the period 2014-2024. Evidence-based STI service packages for conflict settings remain limited. Drawing insights from the COVID-19 crisis, periods of emergencies are associated with an elevated risk of STI surges among key populations. Programmatic data from the conflict further demonstrated this increased risk, reflected in reductions in prevention and early detection activities compared with pre- and post-conflict periods. Self-care and outreach service packages could be critical in these contexts. Community-based organizations (CBOs) should adapt STI services to the wartime environment and evaluate the effectiveness of these interventions post-conflict. CBOs are encouraged to prioritize the implementation of self-care modalities for STI prevention and early detection, expand the availability of telehealth services, and deploy mobile clinics to maximize service continuity. This editorial analyzes STI service delivery within the specific context of the Lebanese war.
9 Apr 2026
Read appraisal →BMJ open
Adverse childhood experiences and cognitive outcomes among older adults in low-income and middle-income countries: a systematic review
OBJECTIVES: While adverse childhood experiences (ACEs) have been consistently linked to poorer cognitive outcomes in later life, far less is known about ACEs' contribution to dementia and cognitive ageing risk in low-income and middle-income countries (LMICs), despite their growing and disproportionate share of global Alzheimer's disease and related dementias (ADRD) burden. This study aimed to systematically review existing evidence on the association between individual ACEs and cognitive outcomes among adults aged 40 years and older in LMIC settings. DESIGN: Systematic review and narrative synthesis. DATA SOURCE: We searched Medline, Embase, PsycINFO and CINAHL from the inception of each database to January 2026. ELIGIBILITY CRITERIA: Observational studies examining the association between individual ACEs and cognitive outcomes among adults aged 40 and older in LMICs. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently screened each record, assessed risk of bias using the Joanna Briggs Institute critical appraisal tool and extracted data. Results were illustrated using descriptive forest plots and a narrative synthesis. RESULTS: Our systematic review included 14 studies, primarily from upper-middle-income countries, that assessed the relationship between individual ACEs and cognitive impairment (n=4) and function (n=10). 10 studies reported significant associations between ACEs and poorer cognitive function and increased risk of cognitive impairment. No study assessed the association between ACEs and ADRD. Parental death, neglect and mental health issues in the family showed consistent associations with cognitive outcomes, whereas experiencing hunger and poor health in childhood showed inconsistent associations. CONCLUSIONS: Our review corroborated evidence from high-income countries that exposure to ACEs is associated with a long-term risk of poorer cognitive outcomes among older populations in LMICs. However, the available literature remains limited, with most studies originating from upper-middle-income countries, few examining cognitive impairment and none assessing ADRD. These findings underscore substantial gaps in knowledge and highlight the need for research across diverse LMIC settings to clarify the role of broader psychosocial and contextual childhood experiences in shaping cognitive ageing and dementia risk. PROSPERO REGISTRATION NUMBER: CRD42024501816.
8 Apr 2026
Read appraisal →European journal of cardiovascular nursing
A review and promise of digital health technologies to promote global cardiovascular health
Digital health technologies include an array of mobile or digital devices and apps that may be used by patients to support lifestyle modification or medical apps that monitor vital parameters and provide data that may influence treatment decisions. The use of digital health technologies is a growing opportunity for disease prevention and management of cardiovascular disease (CVD) for both patients to engage in self-management as well as nurses to monitor patients remotely and facilitate clinical decision support. The aims of this review article are to provide an overview of pertinent digital health technologies in CVD care, address social determinants of health and other enablers/barriers to digital health implementation, and provide perspectives on novel models of care incorporating digital technologies. Based on the latest evidence, recommendations for special considerations and implementation of digital health technologies in low- and middle- vs high-income countries are presented. In addition, tables reviewing functionality of the digital tools and global examples of their use are provided. Extensive empirical evidence from diverse populations suggests adoption of these innovative tools has been low in clinical settings. We provide a table summarizing these barriers and include the facilitators that can improve the adoption of digital health tools to improve behavioral lifestyle modification. For learning purpose, implementation of an innovative model of care is illustrated graphically and in text. We include a call to action to achieve the maximum impact of digital technology to support nurses who work in almost all settings improving CVD prevention and management globally. The multiple roles of nurses using digital health for global CVD prevention and management are discussed in the settings of clinical practice, research, education, public health, health policy/leadership, and informatics.
5 Apr 2026
Read appraisal →PloS one
Perception and acceptance of micronutrient-Fortified Bouillon among Non-Index Household Members: A longitudinal sub-study nested within a randomized trial in Northern Ghana
BACKGROUND: Fortified bouillon cubes offer a scalable strategy to address micronutrient deficiencies in West Africa. However, success depends on household members' perceptions and acceptance. This study assessed changes in perception and acceptance of fortified bouillon cubes over time and explored factors influencing these outcomes among non-index household members (NIHMs) from trial households in Northern Ghana. METHODS: This longitudinal mixed-methods study was nested within a double-masked randomised controlled trial. Households received micronutrient-fortified bouillon cubes (vitamin A, vitamin B12, folic acid, iron, zinc, iodine) or control cubes (iodine only) for nine months. One NIHM (≥15 years) per household (n = 1,047) was enrolled. Structured interviews were conducted during early (months 1-2; n = 731) and late (months 7-9; n = 796) phases. Composite perception (8 items) and acceptance (10 items) scores (range: 1-5; higher scores = more positive perceptions/greater acceptance) were derived from an 18-item validated instrument. Bayesian linear mixed-effects models assessed temporal changes and associated individual and household factors. Twenty-four focus group discussions (months 4-5) explored drivers and barriers. RESULTS: Mean age of NIHMs was 40 ± 14.7 years; 59% were female. Perception scores increased over seven months, from 3.4 to 4.1 (adjusted posterior mean difference [aPMD] = 0.69; 95% credible interval [CrI]: 0.57, 0.81). Acceptance remained high (4.59 to 4.58; aPMD = -0.02; 95% CrI: -0.07, 0.03). No differences were observed between trial arms. At early timepoint, perception scores were lower among household heads compared with other household members, and lower among formal employees compared with farmers. Acceptance was higher among individuals from severely food-insecure households and lower among those from mildly food-insecure households. Focus groups revealed that perceived health benefits, sensory appeal, and cultural fit drove acceptance, while infertility-related myths and food colour changes were barriers. CONCLUSION: Fortified bouillon cubes were accepted, with perceptions improving over time. Public education will be essential to address misconceptions. TRIAL REGISTRATION: ClinicalTrials.gov (NCT05178407); Pan-African Clinical Trial Registry (PACTR202206868437931). The authors confirm that all ongoing and related trials for this intervention are registered.
5 Apr 2026
Read appraisal →BMJ paediatrics open
Oxygen therapy for children with an oxygen saturation of 90-93% in Malawi: the NoGoLO2 pilot randomised controlled trial
OBJECTIVE: Oxygen is a cornerstone treatment for pneumonia with hypoxaemia. WHO guidelines recommend oxygen therapy for children with a peripheral arterial haemoglobin oxygen saturation (SpO2) <90%. Children in low- and middle-income countries with an SpO2 of 90-93% are at increased risk of mortality and may benefit from oxygen therapy. We aimed to determine the feasibility of a randomised controlled trial comparing standard of care (no oxygen), low-flow nasal cannula (LFNC) and high-flow nasal cannula (HFNC) among children with pneumonia and an SpO2 of 90-93%. DESIGN: Pilot, open-label, three-armed randomised control trial (NCT06176664). SETTING: Salima District Hospital, Malawi. PATIENTS: Children 1-59 months old with WHO-defined pneumonia and an SpO2 of 90-93%. INTERVENTIONS: Standard care (no oxygen), LFNC or HFNC. MAIN OUTCOME MEASURES: The primary outcome was feasibility defined as an average of ≤2 protocol deviations per participant. Secondary outcomes included consent refusal, participant attrition and treatment failure within 14 days. Treatment failure was defined as an SpO2 <90% for standard care participants or <94% in the LFNC and HFNC arms despite maximum therapy as described, any new severe respiratory distress (grunting, very severe chest indrawing) or any new WHO-defined emergency sign. RESULTS: Of the 29 eligible patients, 21 (72%) were enrolled and randomised. There was an average of 0.8 (16/21) deviations per participant. Seven (43.8%) protocol violations were related to study intervention protocols and nine (56.3%) to medication availability and routine care. No participants withdrew from the study. Three of 21 participants (14.3%) had treatment failure. All participants were successfully followed to obtain the 14-day outcome. CONCLUSIONS: A three-armed, open-label randomised control trial is feasible to compare standard of care, LFNC and HFNC oxygen for children with pneumonia and an SpO2 of 90-93% in Malawi. TRIAL REGISTRATION NUMBER: NCT06176664.
4 Apr 2026
Read appraisal →BMJ open
Utilisation of brain MRI for the diagnosis of dementia in low and middle-income countries: systematic review and meta-analysis
OBJECTIVES: To synthesise the prevalence and patterns of dementia-relevant structural brain MRI abnormalities in adults with suspected or confirmed dementia in low- and middle-income countries (LMICs), and to summarise MRI protocols and the incremental diagnostic contribution of MRI beyond cognitive screening. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, EMBASE, Web of Science and PsycINFO (January 1990-27 January 2025), plus reference list screening and targeted manual searches. ELIGIBILITY CRITERIA: Observational or diagnostic-accuracy studies from World Bank-defined LMICs including adults (≥50 years) with suspected or confirmed dementia who underwent brain MRI as part of diagnostic evaluation. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently screened, extracted data and assessed risk of bias using ROBINS-I. Random-effects models pooled prevalence of dementia-relevant MRI abnormalities; diagnostic-accuracy outcomes were synthesised narratively due to heterogeneous reference standards and incomplete reporting. RESULTS: 39 LMIC studies were included; 23 studies (2513 participants) contributed to the meta-analysis. Dementia-relevant MRI abnormalities (defined as ≥1 clinically relevant structural abnormality per study definition) were present in 1248/2513 participants. The pooled prevalence of dementia-relevant MRI abnormalities was 58% (95% CI 43% to 72%), with substantial heterogeneity (I²=95%) and a wide prediction interval (8-96%), indicating marked between-study variability; this estimate should be interpreted as a descriptive summary of study-level proportions rather than a precise population parameter. CONCLUSIONS: Brain MRI frequently demonstrates dementia-relevant pathology in LMIC clinical cohorts, usually with mixed neurodegenerative-vascular patterns. Structured visual ratings may add aetiologic specificity beyond cognitive screening, but pooled estimates should be interpreted as summaries of heterogeneous study-level findings rather than precise population parameters, given high heterogeneity and risk of bias. PROSPERO REGISTRATION NUMBER: CRD42024510241.
4 Apr 2026
Read appraisal →BMJ global health
The effects of antenatal interventions on gestational weight gain in low and middle-income countries: a systematic review
BACKGROUND: Gestational weight gain (GWG) during pregnancy is a critical factor that affects maternal and child health outcomes. The considerable burden of inadequate GWG and the rising tide of excessive GWG are overlooked challenges in low and middle-income countries (LMICs). METHODS: This systematic review assessed the impact of antenatal interventions on GWG in LMICs. Randomised controlled trials (RCTs) on antenatal interventions on GWG in LMICs were included. These interventions included educational, behavioural, nutritional supplementation and pharmacological therapies. A systematic literature search was conducted using PubMed, Embase, Web of Science, CINAHL and the Cochrane Library from the start of each database through September 2025. RESULTS: Out of the 33 642 unique articles identified, 70 articles were included in our systematic review, with 59 individual RCTs and 11 cluster RCTs. Nutritional interventions (31 studies) included food and micronutrient supplementations. Micronutrient supplementation such as multiple micronutrient supplementations was found to reduce the risk of severely inadequate or inadequate GWG among pregnant women compared to iron only or iron and folic acid supplementation (Grading of Recommendations Assessment, Development and Evaluation [GRADE]: moderate certainty). Food supplementation showed mixed results, although most trials demonstrated higher mean GWG among undernourished pregnant women and a greater likelihood of achieving Institute of Medicine-recommended ranges (GRADE: moderate certainty). Behavioural (counselling/education) interventions (20 studies) were associated with significant reductions in excessive GWG among pregnant women with overweight or obesity and improved adequacy of GWG (GRADE: moderate certainty). Physical activity (seven studies) was found to reduce the risk of excessive GWG (GRADE: moderate certainty). Combined dietary and physical activity interventions (six studies) were found to reduce the risk of excessive GWG among pregnant women (GRADE: low certainty). CONCLUSIONS: Well-structured antenatal interventions, initiated before 20 weeks of gestation and continuing beyond this period, tailored to local cultural contexts and available resources, can effectively help pregnant women in LMICs in achieving optimal GWG. PROSPERO REGISTRATION NUMBER: CRD42022366354.
4 Apr 2026
Read appraisal →BMJ global health
Impacts of rising food prices on nutritional outcomes and mortality of children in low and middle-income countries: a systematic review
BACKGROUND: Estimates indicate that 45% of mortality among children under 5-year old is linked to nutrition. Increased food prices can reduce access to nutritious foods, increasing nutritional and health risks for children, particularly in low and middle-income countries (LMICs). We synthesised evidence on the relationship of rising food costs with nutritional outcomes and mortality in children in LMICs. METHODS: EMBASE, MEDLINE, Global Health, EconLit, Web of Science and six grey literature sources were searched in September 2023. Searches included key phrases such as 'food price shocks' and 'child malnutrition'. We included any longitudinal study design, with any measure of food price increase and any measure of child malnutrition or mortality as outcomes. Results were analysed narratively with risk of bias assessed using the Newcastle Ottawa Scale. RESULTS: A total of 18 studies were included, covering 104 LMICs. There were 16 repeated cross-sectional or panel studies, one longitudinal cohort study and one quasi-experimental study. Five of these studies were multicountry. 16/18 studies reported a range of adverse nutritional outcomes associated with higher food costs, including mortality (five studies), stunting and low height for age (six studies), and wasting and low weight for height (five studies). Low birth weight, admissions to feeding centres, reduced consumption of rice, fruit, vegetables and animal protein, and reduced haemoglobin concentrations were also associated with higher food prices in one study each. Subgroup analyses were limited although two studies identified larger impacts on children in urban areas, and two studies identified larger impacts where children were exposed to higher food prices at younger ages. DISCUSSION: Rising food prices present a risk to child health and nutrition in LMICs. Policies should prioritise increasing household income alongside structural reforms to mitigate the nutritional impacts of elevated food prices on young children and pregnant women. PROSPERO REGISTRATION NUMBER: CRD42023469198.
4 Apr 2026
Read appraisal →BMC Palliat Care
Identification and mapping of mHealth interventions applied in palliative care in Sub Saharan Africa: a scoping review
BACKGROUND: Although palliative care is very essential for improving quality of life (QOL) by providing relief from pain and other distressing symptoms, its coverage in sub Saharan Africa remains remarkably low. Utilization of mHealth could be a fundamental healthcare system strengthening approach to enhance and promote palliative care in the region. There is paucity of evidence regarding evidence on the use of these interventions in SSA because it is a relatively new concept in the region. Therefore, there was need to identify and map the available/ applied mHealth interventions for palliative care in SSA basing on published and grey literature. AIM: To examine the nature and use of mHealth interventions for palliative care and factors influencing their use in sub Saharan Africa (SSA). METHODS: The review was based on the JBI methodology for scoping review. PUBMED, CINAHL, Embase and Google Scholar databases were searched for published articles with no time restrictions. Unpublished and grey literature was also searched for. Data was extracted from the retrieved sources and synthesized. The findings were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) in a comprehensive and transparent way. RESULTS: A total of 224 articles were identified and 35 of these met the inclusion criterion and were considered for the review. The results show use of mHealth interventions for palliative care in 12 countries of the SSA. Only 12 (35.3%) were app-based, 9(26.5%) were SMS-text-based, 4(11.8%) were telemedicine-based,5(14.7%) were phone call-based, 3(8.8%) were mixed while 1(2.9%) used wearable-sensor-based mHealth interventions. Key uses of mHealth interventions in palliative care included health strengthening, psychosocial support to patients and families, enhancement of compliance to appointments for patients, promotion of adherence to medication, health education, monitoring, evaluation and research and capacity building for palliative care health professionals. A number of influencing factors were identified and they included wide-spread telephone ownership and access, great robustness of telephone and internet connectivity, high degree of perceived usefulness and ease of use, feasibility and acceptability of mHealth. Also, vital barriers such as low levels of technological advancement/expertise, irregularity and paucity of electric power supply, high likelihood to compromise patients' privacy and confidentiality and high illiteracy rates among the population were articulated by the articles. CONCLUSION: About a quarter of SSA countries have incorporated mHealth interventions for palliative care, underscoring the need for further research and development of the technologies. These approaches are quite beneficial to SSA, where there is a disproportionate disease burden and an inadequate healthcare system.
1 Feb 2026
Read appraisal →J Pain Symptom Manage
First-Ever Global Ranking of Palliative Care: 2025 World Map Under the New WHO Framework
CONTEXT: Despite progress in policy and advocacy, global palliative care development remains highly uneven, with large segments of the population lacking access to quality services. A new WHO framework has provided an updated methodology for assessing national palliative care systems. OBJECTIVES: To assess the current state of palliative care development worldwide using the WHO framework and to produce the first global ranking of countries based on their performance across 14 indicators. METHODS: A cross-sectional, mixed-methods study was conducted across 201 countries and territories between 2023 and 2025. Trained national consultants conducted a structured survey based on WHO indicators. Scores were assigned across six domains: policy, essential medicines, service delivery, education, research, and community empowerment. Responses were validated and analyzed to produce a Global Development Score and to classify countries into four development levels: Emerging, Progressing, Established, and Advanced. RESULTS: Of the 201 countries assessed, 40% were classified as Emerging and 28% as Progressing, representing half the global population. Only 14% reached the Advanced level, and 17% were classified as Established. Significant gaps in access to essential medicines and specialized education persist-even in some high-income settings. Despite limited resources Thailand, Uganda,Chile, and Uruguay stand out as regional examples of advanced development. CONCLUSION: This study presents the first global ranking of palliative care development based on WHO indicators. The results highlight persistent disparities and offer a tool for targeted improvement. The Global Development Score enables countries to benchmark progress, identify gaps, and develop strategic responses to expand access and alleviate serious health-related suffering.
1 Nov 2025
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