Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans

Inclusion Criteria

Inclusion Criteria: * Veteran living with HIV and under care at VAMC * 50 years of age and older * Stable antiretroviral therapy (same ARV medications within 3 months) * At least one HIV-1 PCR \< 20 c/ml (viral load) within prior 6 months Exclusion Criteria: * History of AIDS defining illnesses (within 6 months; CDC Criteria) * Myocardial infarction (within 3 months) * Exertional or unstable angina (current chest pain that limits activity) * Severe congestive heart failure (EF \< 20% in last year or NYHA Classification III or IV) * Uncontrolled hypertension (SBP \>180 \&/or DBP \> 110 mm Hg) * Therapy with beta blockers or non-dihydropyridine calcium channel blocker (within 1 month) * Screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code) * Poorly controlled DM within prior 1 month (FBS\>180 mg/dl, RBS \> 299 mg/dl, or HbA1C \> 10) * Receiving treatment for cancer except skin cancer (within 3 months) * Peripheral vascular disease with claudication * Severe arthritis limiting ambulation * Neurologic disease limiting ambulation (requiring assist device) * End stage liver disease (decompensated liver disease) * Chronic renal failure (requiring dialysis) * Severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month) * Use of systemic steroids (testosterone or glucocorticoids) or growth hormone (within 6 months) * Dementia (based on Evaluation to Consent) * Signs or symptoms of any medical comorbidity that would preclude exercise testing or training * Exercise on routine basis (structured aerobic exercise \> 3 times per week) within 1 month * Past medical history of COPD or emphysema AND mMRC score =4