Completed VA Trial Shows Promise: High-Intensity Circuit Training Targets Epigenetic Aging in HIV-Positive Veterans — Key Findings for Clinical Practice

References

1. 1.VA Office of Research and Development. (2024). Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans. ClinicalTrials.gov. NCT04103593. https://clinicaltrials.gov/study/NCT04103593
2. 2.Pathai, S., Bajillan, H., Landay, A. L., & High, K. P. (2014). Is HIV a model of accelerated or accentuated aging? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(7), 833-842. https://doi.org/10.1093/gerona/glt168
3. 3.Deeks, S. G., & Phillips, A. N. (2009). HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ, 338, a3172. https://doi.org/10.1136/bmj.a3172
4. 4.Schouten, J., Wit, F. W., Stolte, I. G., Kootstra, N. A., van der Valk, M., Geerlings, S. E., ... & Reiss, P. (2014). Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals. Clinical Infectious Diseases, 59(12), 1787-1797. https://doi.org/10.1093/cid/ciu701
5. 5.Brothers, T. D., Rockwood, K., Theou, O., Zona, S., Lazzaretti, G., Carli, F., ... & Guaraldi, G. (2014). Fatigue in HIV infection at fifty: a multi-centre cross-sectional study. PLoS One, 9(10), e111209. https://doi.org/10.1371/journal.pone.0111209
6. 6.Pedersen, B. K., & Saltin, B. (2015). Exercise as medicine–evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian Journal of Medicine & Science in Sports, 25(6), 807-814. https://doi.org/10.1111/sms.12581