Not_yet_recruitingNANCT07530562

A Health Coach-Led Digital Lifestyle Intervention (HEALDI) for the Regression of Diffuse Myocardial Fibrosis: A Randomised Controlled Trial

Sponsor: National University of Singapore

Trial Details

ConditionMyocardial Fibrosis, Left Ventricle Hypertrophy, Hypertensive Disease, Hypertension
InterventionHEALDI Intervention
PhaseNA
StatusNot_yet_recruiting
Participants200
Est. Completion1 June 2028
Last Updated15 Apr 2026

Primary Outcome

Regression of diffuse myocardial fibrosis

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * Left ventricular hypertrophy on cardiovascular magnetic resonance based on local age and sex specific criteria * Age 40-70 years old * Has internet access * Owns and uses a smartphone daily * Able to converse and comprehend the English or Chinese language Exclusion Criteria: * History of major cardiovascular events (MACE), which is defined as coronary heart disease death, non-fatal myocardial infarction, stroke * Diagnosed with secondary causes of hypertension (E.g., renal causes - renal artery stenosis, chronic renal failure; endocrine causes- pheochromocytoma, Cushing's syndrome, hyperthyroidism; cardiac causes - coarctation of the aorta) * Diagnosed with significant coronary artery disease with previous percutaneous intervention or coronary artery bypass surgeries * Diagnosed with cardiac arrhythmias such as atrial fibrillation and frequent premature ventricular contractions * Diagnosed with inherited/acquired cardiomyopathies (E.g., hypertrophic cardiomyopathy, dilated cardiomyopathy) * Diagnosed with infiltrative disease (E.g., cardiac amyloid, cardiac sarcoid) * Contraindications to Brain and Cardiac Magnetic Resonance or gadolinium contrast (E.g., renal failure- eGFR \<30ml/min/m2 or documented contrast allergy; implantable devices such as cardiac pacemakers, brain aneurysms or clips, metal implants (including braces), foreign bodies in the eye; claustrophobia; end organ failure; women who are pregnant or breast-feeding) * Any pre-existing medical conditions or disabilities that limits their participation in lifestyle interventions (E.g., Dementia) * Individuals who have achieved the Singapore physical activity guideline of 150 minutes of moderate intensity exercise or 75 minutes of vigorous intensity exercise per week or an equivalent combination per week * Limited life expectancy of less than 12 months * Participating in other research projects involving behavioural therapy or changes related to physical activity

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