Health Technology/clinical-trials

Phase III Digital Lifestyle Trial Opens: AI-Assisted Health Coaching vs Control for Myocardial Fibrosis Regression — What Cardiologists Need to Know

247 Health News Editorial

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17 Apr 2026

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4 min read

·clinical-trials

The HEALDI trial investigates whether AI-assisted digital health coaching can reverse myocardial fibrosis in hypertensive heart disease. This Singapore-based RCT randomises 200 participants to 12-month lifestyle intervention versus control, with cardiac MRI endpoints.

Originally reported by ClinicalTrials.gov

References

  1. 1.National University of Singapore. (2024). A Health Coach-Led Digital Lifestyle Intervention (HEALDI) for the Regression of Diffuse Myocardial Fibrosis: A Randomised Controlled Trial. ClinicalTrials.gov. NCT07530562. https://clinicaltrials.gov/study/NCT07530562
  2. 2.Gonzalez, A., Schelbert, E. B., Diez, J., & Butler, J. (2018). Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. Journal of the American College of Cardiology, 71(15), 1696-1706. https://doi.org/10.1016/j.jacc.2018.02.021
  3. 3.Schulz, K. F., Altman, D. G., & Moher, D. (2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332. https://doi.org/10.1136/bmj.c332
  4. 4.Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., ... & Kjeldsen, S. E. (2018). 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal, 39(33), 3021-3104. https://doi.org/10.1093/eurheartj/ehy339
  5. 5.Aoki, T., Fukumoto, Y., Sugimura, K., Oikawa, M., Nakazato, K., Yasuda, S., & Shimokawa, H. (2011). Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. Journal of Cardiac Failure, 17(8), 634-641. https://doi.org/10.1016/j.cardfail.2011.06.005
  6. 6.Pandey, A., Parashar, A., Kumbhani, D., Agarwal, S., Garg, J., Kitzman, D., ... & Berry, J. (2015). Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circulation Heart Failure, 8(1), 33-40. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001615
  7. 7.Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G., Coats, A. J., ... & van Veldhuisen, D. J. (2016). 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 37(27), 2129-2200. https://doi.org/10.1093/eurheartj/ehw128
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