ActivePHASE3NCT05766631

Treating Polysubstance Use in Methadone Maintenance: Application of Novel Digital Technology

Sponsor: Friends Research Institute, Inc.

Trial Details

Condition	Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
Intervention	DynamiCare Health; Methadone Treatment-As-Usual
Phase	PHASE3
Status	Active
Participants	240
Est. Completion	30 June 2027
Last Updated	19 May 2026

Primary Outcome

Retention in Methadone Treatment through 48 Weeks

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: 1. Age 18 or older 2. Cocaine use (self-reported in the past 30 days) 3. Willing and able to provide informed consent Exclusion Criteria: 1. Severe psychiatric disorders 2. On home detention 3. Visual impairment that would make the use of the phone app impractical 4. Living arrangement that currently restricts phone access

Trial Sites

Countries

United States

View Registry Entry

Related Analysis

Phase III Trial Tests Digital Contingency Management App for Polysubstance Use in Methadone Patients — Novel Approach to Retention and Abstinence

A phase III trial tests DynamiCare Health, a smartphone app using remote drug testing and financial incentives, as an add-on to methadone maintenance therapy for patients with concurrent opioid and cocaine use disorders. The study aims to improve 48-week retention rates and reduce polysubstance use through digital contingency management.

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