CompletedNANCT07575802

Lower Limb Muscle Strength and Power Predict Exercise-Induced Prefrontal Hemodynamic Response: An Interpretable Machine Learning Study Using fNIRS Data

Sponsor: Lincoln University College

Trial Details

ConditionPrefrontal Hemodynamics, Muscle Strength, Physical Performance
InterventionStandardized Lower-Limb Physical Performance Assessment and Aerobic Exercise Task
PhaseNA
StatusCompleted
Participants256
Est. Completion15 Mar 2025
Last Updated8 May 2026

Primary Outcome

Area Under the Curve of Oxygenated Hemoglobin (Δ HbO AUC) during Aerobic Exercise

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: 1. Healthy adults aged between 18.00 and 60.00 years. 2. Must be able to perform standardized lower-limb physical assessments, including isokinetic strength testing and explosive power tests (e.g., CMJ, SJ, and 30m sprints). 3. Capability to complete a 6-minute aerobic cycling task at a moderate intensity (60% VO\_2max). 4. Physically cleared for exercise as determined by a Physical Activity Readiness Questionnaire (PAR-Q). 5. Willingness to undergo functional near-infrared spectroscopy (fNIRS) monitoring with a Scalp Coupling Index (SCI) ≥ 0.7. Exclusion Criteria: 1. History of musculoskeletal injuries to the lower limbs within the past 6 months that would impede maximum voluntary contraction (MVC) or high-intensity efforts. 2. Known cardiovascular, respiratory, or neurological conditions that contraindicate maximal exercise testing (VO\_2max ramp protocol). 3. Body Mass Index (BMI) or health status that prevents the safe completion of high-impact explosive power tests like the 30cm drop jump (RSI assessment). 4. Presence of excessive motion artifacts or poor fNIRS signal quality, specifically a Signal-to-Noise Ratio (SNR) \< 5 dB or motion artifact frame ratio ≥$ 10%.

Trial Sites

Countries

Russia
View Registry Entry

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