Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)
Sponsor: Vanderbilt University Medical Center
Trial Details
| Condition | Aging, Depression, Cognitive Symptoms |
| Intervention | Depression Cognitive Training; Non-Specific Cognitive Training; tDCS (active stimulation); tDCS (sham stimulation) |
| Phase | NA |
| Status | Not_yet_recruiting |
| Participants | 69 |
| Est. Completion | 30 May 2028 |
| Last Updated | 15 May 2026 |
Primary Outcome
NIH Examiner; Resting state fMRI functional connectivity
Eligibility Criteria
Inclusion Criteria
Inclusion Criteria: * Age \> 60 years * Evidence of executive dysfunction via SUBJECTIVE COMPLAINTS (At least one subdomain of the Behavior Rating Inventory of Executive Function in Adults (BRIEF-A) at T \> 65, or At least one average score of \> 1.5 on Planning, Organization, or Attention subdomains of the Everyday Cognition Scale (ECog)) or OBJECTIVE PERFORMANCE (At least one demographically adjusted z-score \> -1.0 SD below the mean on a measure of executive functioning (Digits backward, Trails B, or total Verbal Fluency) on the National Alzheimer's Coordinating Center (NACC) Uniform Data Set 3.0). * DSM-5 diagnosis of a current or past (within last 3 years) depressive episode (e.g., Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD)) via the using the Structured Clinical Interview for DSM-5 Disorders (SCID-5). * Presence of 2 or more lifetime depressive episodes to be considered "recurrent." * Either stable antidepressant regimen for at least 6 weeks or no current antidepressant treatment (no plans to change treatment over course of study). * Fluent in English Exclusion Criteria: * Other psychiatric conditions via the SCID-5 (including history of bipolar disorder and psychosis, excluding comorbid anxiety disorders) * Severe depression (MADRS score \> 29) * Acute suicidality on clinical evaluation by study clinician and via response on MADRS item 10 (score of 4 or more would require further assessment) * Acute grief (occurring within past month) * History of alcohol use disorder or substance use disorder of moderate or greater severity in the last 12 months * Medications that would significantly interfere with tDCS effects (i.e., sodium channel blockers, GABA-ergic or glutamatergic drugs; see Appendix B for exclusionary list)40 * Primary neurological disorder (e.g., epilepsy, brain tumor, Parkinson's disease, Alzheimer's disease, dementia diagnosis) * Montreal Cognitive Assessment (MoCA) \< 23 * Primary amnestic cognitive profile (\>1.5 SD below demographically-adjusted mean on NACC memory measures in context otherwise normal cognitive profile, or per clinician judgement) * Any physical or intellectual disability affecting ability to complete assessments * Unstable medical illness needing urgent treatment * MRI contraindications * Electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) in last 2 months * Current involvement in psychotherapy * Current involvement in other research studies (including but not limited to: neuromodulation \[TMS or tDCS\] or investigational drug studies). Observational studies \[without intervention\] are acceptable.
Trial Sites
Countries
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service