Health Technology/clinical-trials

Phase II Trial Opens: Combined tDCS and Cognitive Training vs Standard Approaches in Late-Life Depression with Executive Dysfunction — What Clinicians Need to Know

247 Health News Editorial

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24 May 2026

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3 min read

·clinical-trials

New trial combines brain stimulation with cognitive training to address persistent thinking problems in older adults with recurrent depression. The COG-D-R study targets executive dysfunction that often persists despite successful mood treatment.

Originally reported by ClinicalTrials.gov

References

  1. 1.Alexopoulos, G. S. (2019). Mechanisms and treatment of late-life depression. Translational Psychiatry, 9(1), 188. https://doi.org/10.1038/s41398-019-0514-6
  2. 2.Brunoni, A. R., & Vanderhasselt, M. A. (2014). Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: a systematic review and meta-analysis. Brain and Cognition, 86, 1-9. https://doi.org/10.1016/j.bandc.2014.07.001
  3. 3.Butters, M. A., Whyte, E. M., Nebes, R. D., Begley, A. E., Dew, M. A., Mulsant, B. H., ... & Becker, J. T. (2004). The nature and determinants of neuropsychological functioning in late-life depression. Archives of General Psychiatry, 61(6), 587-595. https://doi.org/10.1001/archpsyc.61.6.587
  4. 4.Koenig, A. M., Bhalla, R. K., & Butters, M. A. (2014). Effects of the antidepressant duloxetine on cognitive function in patients with major depressive disorder. International Journal of Neuropsychopharmacology, 17(9), 1-10. https://doi.org/10.1017/S1461145713001600
  5. 5.Morimoto, S. S., & Alexopoulos, G. S. (2013). Cognitive impairment in geriatric depression: implications for treatment. Psychiatric Clinics of North America, 36(4), 517-531. https://doi.org/10.1016/j.psc.2013.01.007
  6. 6.Motter, J. N., Pimontel, M. A., Rindskopf, D., Devanand, D. P., Doraiswamy, P. M., & Sneed, J. R. (2016). Computerized cognitive training and functional recovery in major depressive disorder: a meta-analysis. Journal of Psychiatric Research, 73, 30-37. https://doi.org/10.1016/j.jpsychires.2015.11.005
  7. 7.Semkovska, M., & Ahern, E. (2017). Cognitive function following recovery from major depressive disorder: a systematic review and meta-analysis. The Lancet Psychiatry, 4(11), 851-859. https://doi.org/10.1016/S2215-0366(17)30190-9
  8. 8.Vanderbilt University Medical Center. (2024). Cognitive Enhancement in Recurrent Depression (The COG-D-R Study). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07527273
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247 Health News Editorial

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