Optimization of Antibiotic Treatment in Patients With a Reported Penicillin Allergy Using a Digital Clinical Decision Support Tool.

Inclusion Criteria

Inclusion Criteria: * Age ≥ 16 years * Hospitalized patients * Diagnosis of infection requiring systemic antibiotic therapy * Documented penicillin and/or cephalosporin allergy in the electronic medical record or self-reported allergy during current admission * For the retrospective cohort: patients previously admitted to hospital or emergency department (≥16 hours) with a recorded penicillin allergy label * Ability to understand study information and provision of written informed consent (prospective cohort only) Exclusion Criteria: * Patients with a reported penicillin allergy who do not require systemic antibiotic treatment * Patients admitted to intensive care or intermediate care units * Patients receiving outpatient hospital care or dialysis units * Patients in end-of-life care or receiving palliative care * Patients receiving antibiotics for surgical prophylaxis only