Health Technology/clinical-trials

Digital Decision Support Tool Aims to Optimise Beta-Lactam Use in Patients with Reported Penicillin Allergies

247 Health News Editorial

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8 June 2026

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3 min read

·clinical-trials

A completed Spanish study evaluated a digital clinical decision support tool to optimise beta-lactam antibiotic prescribing in hospitalised patients with reported penicillin allergies. The intervention addressed the challenge that over 90% of patients with penicillin allergy labels receive alternative antibiotics despite fewer than 10% having confirmed allergies.

Originally reported by ClinicalTrials.gov

References

  1. 1.Althaia Xarxa Assistencial Universitària de Manresa. (2024). Optimization of antibiotic treatment in patients with a reported penicillin allergy using a digital clinical decision support tool. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07604597
  2. 2.Blumenthal, K. G., Peter, J. G., Trubiano, J. A., & Phillips, E. J. (2019). Antibiotic allergy. The Lancet, 393(10167), 183-198. https://doi.org/10.1016/S0140-6736(19)30558-8
  3. 3.Macy, E., & Contreras, R. (2014). Health care use and serious infection prevalence associated with penicillin allergy in hospitalized patients: A cohort study. Journal of Allergy and Clinical Immunology, 133(3), 790-796. https://doi.org/10.1016/j.jaci.2013.09.021
  4. 4.Trubiano, J. A., & Phillips, E. J. (2019). Antimicrobial stewardship's new weapon? A review of antibiotic allergy and pathways to 'de-labeling'. Current Opinion in Infectious Diseases, 32(6), 571-578. https://doi.org/10.1097/QCO.0000000000000581
  5. 5.Australian Commission on Safety and Quality in Health Care. (2018). Antimicrobial stewardship in Australian health care. ACSQHC. https://www.safetyandquality.gov.au/publications-and-resources/resource-library/antimicrobial-stewardship-australian-health-care-2018
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247 Health News Editorial

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