THE ROLE OF FRAILTY INDICES AND PREOPERATIVE BIOMARKERS IN PREDICTING MYOCARDIAL INJURY AFTER NON-CARDIAC SURGERY IN ELDERLY ORTHOPEDIC PATIENTS: A MACHINE LEARNING ANALYSIS
Sponsor: DİLEK KALAYCI
Trial Details
| Condition | Geriatric Patients, Postoperative Complications, Frailty, Myocardial Ischemia, Hip Surgeries |
| Intervention | Preoperative Risk Assessment and Machine Learning Modeling |
| Status | Active |
| Participants | 600 |
| Est. Completion | 1 June 2026 |
| Last Updated | 4 May 2026 |
Primary Outcome
Incidence of Myocardial Injury after Non-cardiac Surgery (MINS)
Eligibility Criteria
Inclusion Criteria
Inclusion Criteria: * All patients aged 65 years and older. * Patients undergoing major orthopedic surgery (hip fracture repair, total knee/hip arthroplasty, and revision surgeries). * Patients operated on within the designated study period (January 2021 - December 2023). * Patients with complete access to preoperative clinical data (comorbidities, medication use) and baseline laboratory parameters (Hemoglobin, Creatinine, Albumin). * Patients who had at least one postoperative cardiac troponin (hs-cTn) measurement within the first 72 hours after surgery. Exclusion Criteria: * Patients with a documented history of acute myocardial infarction or elevated baseline troponin levels in the preoperative period (to differentiate acute injury from surgical causes). * Patients with end-stage renal disease (ESRD) requiring dialysis (as chronic kidney dysfunction persistently elevates baseline troponin levels). * Patients with missing critical preoperative data or incomplete postoperative troponin follow-up.
Trial Sites
Countries
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