ActiveNCT07566013

THE ROLE OF FRAILTY INDICES AND PREOPERATIVE BIOMARKERS IN PREDICTING MYOCARDIAL INJURY AFTER NON-CARDIAC SURGERY IN ELDERLY ORTHOPEDIC PATIENTS: A MACHINE LEARNING ANALYSIS

Sponsor: DİLEK KALAYCI

Trial Details

ConditionGeriatric Patients, Postoperative Complications, Frailty, Myocardial Ischemia, Hip Surgeries
InterventionPreoperative Risk Assessment and Machine Learning Modeling
StatusActive
Participants600
Est. Completion1 June 2026
Last Updated4 May 2026

Primary Outcome

Incidence of Myocardial Injury after Non-cardiac Surgery (MINS)

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * All patients aged 65 years and older. * Patients undergoing major orthopedic surgery (hip fracture repair, total knee/hip arthroplasty, and revision surgeries). * Patients operated on within the designated study period (January 2021 - December 2023). * Patients with complete access to preoperative clinical data (comorbidities, medication use) and baseline laboratory parameters (Hemoglobin, Creatinine, Albumin). * Patients who had at least one postoperative cardiac troponin (hs-cTn) measurement within the first 72 hours after surgery. Exclusion Criteria: * Patients with a documented history of acute myocardial infarction or elevated baseline troponin levels in the preoperative period (to differentiate acute injury from surgical causes). * Patients with end-stage renal disease (ESRD) requiring dialysis (as chronic kidney dysfunction persistently elevates baseline troponin levels). * Patients with missing critical preoperative data or incomplete postoperative troponin follow-up.

Trial Sites

Countries

Turkey (Türkiye)
View Registry Entry

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