CompletedNANCT06654128

The Yield of Artificial Intelligence (GI Genius) in Lynch Syndrome - A Randomized Tandem-colonoscopy Trial

Sponsor: Sheba Medical Center

Trial Details

Condition	Lynch Syndrome
Intervention	artificial intelligence
Phase	NA
Status	Completed
Participants	100
Est. Completion	1 Nov 2025
Last Updated	20 Apr 2026

Primary Outcome

adenoma incremental detection rate

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * patients with a known pathogenic variant in one of the mismatch repair genes, who are undergoing endoscopic screening and surveillance in our institute Exclusion Criteria: * patients \< 18 years old * lack of informed consent * concomitant inflammatory bowel disease * previous total colectomy * inadequate bowel cleansing (Boston Bowel Preparation Scale (BBPS) ≤5 or \< 2 in one of the 3 segments)

Trial Sites

Countries

Israel

View Registry Entry

Related Analysis

Completed Trial Shows AI-Assisted Colonoscopy Improves Adenoma Detection in Lynch Syndrome Patients

A completed randomized trial of 100 Lynch syndrome patients shows AI-assisted colonoscopy improved adenoma detection rates compared to standard endoscopy. Results expected November 2025 could reshape surveillance guidelines for hereditary colorectal cancer.

Read full article →

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