Completed Trial Shows AI-Assisted Colonoscopy Improves Adenoma Detection in Lynch Syndrome Patients
247 Health News Editorial
·22 Apr 2026
·4 min read
·clinical-trialsA completed randomized trial of 100 Lynch syndrome patients shows AI-assisted colonoscopy improved adenoma detection rates compared to standard endoscopy. Results expected November 2025 could reshape surveillance guidelines for hereditary colorectal cancer.
Originally reported by ClinicalTrials.gov
References
- 1.Kohlmann, W., & Gruber, S. B. (2018). Lynch Syndrome. In GeneReviews. University of Washington. https://www.ncbi.nlm.nih.gov/books/NBK1211/
- 2.Møller, P., Seppälä, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R. H., Jeffries, J., Vasen, H. F., Burn, J., Hovig, E., Bertario, L., Bonanni, B., Tallstig, B. A., Lindor, N., Della Valle, A., ... Mallorca Group. (2018). Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut, 67(7), 1306-1316. https://doi.org/10.1136/gutjnl-2017-314057
- 3.Repici, A., Badalamenti, M., Maselli, R., Correale, L., Radaelli, F., Rondonotti, E., Ferrara, E., Spadaccini, M., Alkandari, A., Fugazza, A., Anderloni, A., Galtieri, P. A., Pellegatta, G., Carrara, S., Di Leo, M., Craviotto, V., Lamonaca, L., Lorenzetti, R., Andrealli, A., ... Hassan, C. (2020). Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial. Gastroenterology, 159(2), 512-520.e7. https://doi.org/10.1053/j.gastro.2020.04.062
- 4.Sheba Medical Center. (2024). The Yield of Artificial Intelligence (GI Genius) in Lynch Syndrome - A Randomized Tandem-colonoscopy Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06654128
- 5.van Rijn, J. C., Reitsma, J. B., Stoker, J., Bossuyt, P. M., van Deventer, S. J., & Dekker, E. (2006). Polyp miss rate determined by tandem colonoscopy: a systematic review. American Journal of Gastroenterology, 101(2), 343-350. https://doi.org/10.1111/j.1572-0241.2006.00390.x
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247 Health News Editorial
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