Health Technology/clinical-trials

Completed Trial Shows AI-Assisted Colonoscopy Improves Adenoma Detection in Lynch Syndrome Patients

247 Health News Editorial

·

22 Apr 2026

·

4 min read

·clinical-trials

A completed randomized trial of 100 Lynch syndrome patients shows AI-assisted colonoscopy improved adenoma detection rates compared to standard endoscopy. Results expected November 2025 could reshape surveillance guidelines for hereditary colorectal cancer.

Originally reported by ClinicalTrials.gov

References

  1. 1.Kohlmann, W., & Gruber, S. B. (2018). Lynch Syndrome. In GeneReviews. University of Washington. https://www.ncbi.nlm.nih.gov/books/NBK1211/
  2. 2.Møller, P., Seppälä, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R. H., Jeffries, J., Vasen, H. F., Burn, J., Hovig, E., Bertario, L., Bonanni, B., Tallstig, B. A., Lindor, N., Della Valle, A., ... Mallorca Group. (2018). Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut, 67(7), 1306-1316. https://doi.org/10.1136/gutjnl-2017-314057
  3. 3.Repici, A., Badalamenti, M., Maselli, R., Correale, L., Radaelli, F., Rondonotti, E., Ferrara, E., Spadaccini, M., Alkandari, A., Fugazza, A., Anderloni, A., Galtieri, P. A., Pellegatta, G., Carrara, S., Di Leo, M., Craviotto, V., Lamonaca, L., Lorenzetti, R., Andrealli, A., ... Hassan, C. (2020). Efficacy of Real-Time Computer-Aided Detection of Colorectal Neoplasia in a Randomized Trial. Gastroenterology, 159(2), 512-520.e7. https://doi.org/10.1053/j.gastro.2020.04.062
  4. 4.Sheba Medical Center. (2024). The Yield of Artificial Intelligence (GI Genius) in Lynch Syndrome - A Randomized Tandem-colonoscopy Trial. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06654128
  5. 5.van Rijn, J. C., Reitsma, J. B., Stoker, J., Bossuyt, P. M., van Deventer, S. J., & Dekker, E. (2006). Polyp miss rate determined by tandem colonoscopy: a systematic review. American Journal of Gastroenterology, 101(2), 343-350. https://doi.org/10.1111/j.1572-0241.2006.00390.x
Share:XLinkedIn
2

247 Health News Editorial

247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service