Lysosomal Membrane Proteins: Key Regulators of Glucose Metabolism and Its Associated Diseases

Clinical Snapshot

Key Findings

• P Value: Not applicable for systematic review

• Effect Size: Not quantified in abstract

• Primary Outcome: LMPs play core roles in regulating glucose homeostasis through multiple mechanisms

• Nnt Or Sensitivity: Not applicable - mechanistic review focus

• Confidence Interval: Not provided

Clinical Application

Limited by lack of specific therapeutic recommendations or clinical protocols Relevant to Australian diabetes management guidelines and PBS-listed metabolic therapies, though specific applications unclear from abstract Patients with metabolic disorders, diabetes, and glucose homeostasis dysfunction

Abstract

Glucose homeostasis, which is critical for maintaining energy supply and health, involves glycogen metabolism, glycolysis, and gluconeogenesis. Lysosomal membrane proteins (LMPs) play core roles in regulating these processes. However, no focused systematic review of the topic has been reported. This review provides an in-depth analysis of the central roles of LMPs in glucose metabolism, focusing on the regulation of glucose homeostasis and their potential effects on metabolic diseases through the regulation of autophagy, signaling networks, specialized transporter functions, and other relevant mechanisms. In general, LMPs play core roles in lysosomal biosynthesis, and an in-depth study of their relationship with glucose metabolism could significantly highlight the important contribution of lysosomes in the development of related diseases.

References

1. 1.Xu, J., Jin, Y., Liu, S., Dong, S., Xiong, C., Zhang, R., Pei, W., Wu, X., Wang, L., & Gao, J. (2026). Lysosomal membrane proteins: Key regulators of glucose metabolism and its associated diseases. *FASEB Journal*, *40*(8), e23456. https://doi.org/10.1096/fj.202501587R