Recruiting🇦🇺 Australian SiteNCT06067347

Integration of Machine Learning and Genomics to Predict Outcomes for Newly Diagnosed, Relapsed and Refractory Mature T-cell and NK/T-cell Lymphomas: a Global Study of the PETAL Consortium

Sponsor: Massachusetts General Hospital

Trial Details

ConditionT-Cell and NK-Cell Neoplasm
StatusRecruiting
Participants1,200
Est. Completion1 Jan 2028
Last Updated9 Apr 2026

Primary Outcome

Overall Survival; Progression-free Survival; Duration of Response; Time to progression; Number of subjects proceeding to stem cell transplantation; Association of tumor specific somatic variants with treatment response

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * Untreated, relapsed, or refractory histologically confirmed mature T-cell or NK-cell neoplasm. * All subtypes of PTCL are eligible except for T-cell large granular lymphocytic leukemia, cutaneous T-cell lymphoma such as but not limited to mycosis fungoides and transformation, Sézary syndrome, and primary cutaneous CD30+ disorders. Exclusion Criteria: * Precursor T/NK neoplasms, T-cell large granular lymphocytic leukemia, cutaneous T-cell lymphoma such as but not limited to mycosis fungoides and transformation, Sézary syndrome, and primary cutaneous CD30+ disorders. * Adults who are unable to consent, individuals who are not yet adults such as infants, children and teenagers, pregnant women, and prisoners.

Trial Sites

🇦🇺 Australian Sites (2)

Countries

United StatesAustraliaJapanSouth Africa
View Registry Entry

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