RecruitingNCT06555757

Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation

Sponsor: Cambridge University Hospitals NHS Foundation Trust

Trial Details

ConditionHeart Failure
InterventionHeight, weight, and BMI; Medical history; Physical examination; Venous blood samples; Resting vital signs; Transthoracic echocardiogram; Sound recordings; Lung ultrasound; KCCQ questionnaire; ASCEND-HF score; Composite Everest congestion score; Bio impedance and total body water measurement
StatusRecruiting
Participants250
Est. Completion15 Aug 2027
Last Updated12 May 2026

Primary Outcome

Area under receiver operating curve (AUC); Negative and positive predictive value (NPV and PPV); Sensitivity; Specificity

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * Male or Female, aged 18 years or above. * Diagnosed with chronic stable heart failure NYHA Class 3 or 4 (either during most recent cardiology/heart failure clinic visit, or ADHF during recent/current hospitalization). * Participant is willing and able to give informed consent for participation in the study. * Participant has a smartphone device and can download a purposely designed mobile application on their phone (with guidance from the study investigators) or is willing to have sound recordings via a smartphone device loaned for the purpose of the study. Exclusion Criteria: * Unable to provide consent * Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula * Patients with currently known pneumonia * Patients with known significant pulmonary disease including asthma, COPD, pulmonary fibrosis/interstitial lung disease, pulmonary hemorrhage. * Patients with current Pulmonary embolus * Patients with other intercurrent acute symptomatic illness (e.g., viral/bacterial infection) at time of recording * Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula * Patients with tracheostomy or who have undergone a surgical procedure to the head/neck/larynx which would affect the normal functioning of the vocal cords. * Aphasic * Patients excluded at PI discretion

Trial Sites

Countries

United Kingdom
View Registry Entry

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