Not_yet_recruitingNCT06527079

Evaluation of Clinical Decision Support in Opioid Tapering

Sponsor: University of Colorado, Denver

Trial Details

Condition	Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing, Opioid Overdose, Prevention
Intervention	Opioid Tapering Pathway Clinical Decision Support (CDS)
Status	Not_yet_recruiting
Participants	200,000
Est. Completion	1 Dec 2026
Last Updated	23 Apr 2026

Primary Outcome

Percentage of encounters tapering within CDC guidelines

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: Primary care patients being tapered from an opioid. Tapering patients: * Have an active opioid prescription for more than 3 months and * Prescribed more than 90 morphine milligram equivalents (MME) per day or * Co-prescribed an opioid and benzodiazepine or * Received a reduction in opioid dosage by more than 5% MME per day Exclusion Criteria: * Patients \<12 and \>89 * Patients with active cancer diagnosis in last 1 year * Patients with hospice care/palliative care order * Patients with sickle cell disease diagnosis

View Registry Entry

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Large-Scale Pragmatic Trial Tests Clinical Decision Support for Safe Opioid Tapering in Primary Care — 200,000 Patients Enrolled

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