Not_yet_recruitingNANCT06898138

Acute Stimulation for the Modulation of Epileptic Events With a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy

Sponsor: Mayo Clinic

Trial Details

Condition	Epilepsy
Intervention	Brain Interchange System
Phase	NA
Status	Not_yet_recruiting
Participants	8
Est. Completion	15 Feb 2029
Last Updated	18 May 2026

Primary Outcome

Feasibility of Detection of Stereotyped HFOs; Feasibility of Delivering Closed-Loop Stimulation

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * Patients with medically refractory epilepsy, who have been deemed appropriate candidates for intracranial EEG monitoring * Adult men and women (18≤ age \<70 years) * Children (3≤ age \<18 years) * Includes women and minorities Exclusion Criteria: • Subjects will be excluded if their condition makes them unable to continue with recordings.

Trial Sites

Countries

United States

View Registry Entry

Related Analysis

Phase I Feasibility Trial Opens: Novel Closed-Loop Brain Stimulation System Targets Pre-Seizure Activity in Drug-Resistant Epilepsy

Mayo Clinic launches first-in-human trial of novel Brain Interchange System that targets pre-seizure brain activity to prevent epileptic seizures, rather than waiting to abort them after onset. The study evaluates closed-loop stimulation guided by high-frequency oscillations in 8 patients with drug-resistant epilepsy.

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