CompletedNANCT06212557

Evaluation of KIOS in a 12-week Randomized Controlled Trial

Sponsor: The University of Texas Health Science Center at San Antonio

Trial Details

Condition	Opioid Use Disorder
Intervention	KIOS App; KIOS App education; Treatment as usual
Phase	NA
Status	Completed
Participants	116
Est. Completion	29 Dec 2025
Last Updated	13 July 2026

Primary Outcome

Retention in treatment

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: 1. Male or female outpatients 18 years of age or older 2. Patients must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent. 3. DSM-5 (Diagnostic and Statistical Manual of Mental Disorders fifth edition) criteria for opioid use disorder 4. Ability to access KIOS via smartphone or tablet 5. Recently (less than 6 months) enrolled in and currently participating in MOUD at a clinic in Texas Exclusion Criteria: 1. Unwilling or unable to comply with study requirements 2. Psychiatric or medical disorder interfering with ability to use the app 3. Incarceration

Trial Sites

Countries

United States

View Registry Entry

Related Analysis

Phase III Digital Therapeutics Trial: KIOS App vs Standard Care in Opioid Use Disorder — What Addiction Medicine Specialists Need to Know

New RCT evaluates KIOS mobile app versus standard care for opioid use disorder treatment retention. The 116-participant trial addresses critical dropout challenges in medication-assisted treatment programs.

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