RecruitingNANCT06799117

Adaptive Decision Support for Addiction Treatment (ADAPT)

Sponsor: Yale University

Trial Details

Condition	Opioid Use Disorder
Intervention	EMBED CDS; Nurse prompt to complete COWS; Provider Prompt; Patient facing materials; Optimized EMBED; Name of Intervention
Phase	NA
Status	Recruiting
Participants	1,912
Est. Completion	31 Mar 2028
Last Updated	11 June 2026

Primary Outcome

Proportion of encounters with Buprenorphine initiation in the ED; Proportion of alerted encounters with CDS engagement

Eligibility Criteria

Inclusion Criteria

Inclusion Criteria: * Emergency department patient * 18 years of age or older * Moderate to severe opioid use disorder Exclusion Criteria: * Under 18 years of age * Pregnant * Currently receiving medication for opioid use disorder

Trial Sites

Countries

United States

View Registry Entry

Related Analysis

Phase III Trial Opens: Novel Clinical Decision Support System vs Standard Care for Emergency Department Opioid Use Disorder Treatment — What Clinicians Need to Know

The ADAPT trial evaluates an optimised clinical decision support system to increase emergency department buprenorphine initiation for opioid use disorder. This 1,912-patient study could transform acute addiction care through automated workflows and real-time clinical guidance.

Read full article →

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service