Evaluating the Impact of HeartAge, Genetic Risk Scores, and HOPE, an Evidence-based Digital Platform for Behaviour Change, on Cardiovascular Disease Risk Factors
Sponsor: National University of Singapore
Trial Details
| Condition | Cardiovascular Diseases |
| Intervention | HeartAge; HOPE-CVD Mobile App; Genetic Risk Score |
| Phase | NA |
| Status | Completed |
| Participants | 1,121 |
| Est. Completion | 10 Oct 2025 |
| Last Updated | 27 Apr 2026 |
Primary Outcome
Change in 10-yr predicted absolute risk of cardiovascular disease; Change in Health-Related Quality of Life; Change in Goal-directed behaviours for living well
Eligibility Criteria
Inclusion Criteria
Inclusion Criteria: 1. Aged 30-74 years; 2. Singapore citizen, or permanent resident 3. Able to read and understand English 4. Have access to and is comfortable using an internet-enabled device 5. At least 5% risk of CVD, as measured by the Framingham Risk Score (FRS), based on previous health screening results Exclusion Criteria: 1. Existing heart disease or a prior history of coronary artery disease/angina/myocardial infarction/revascularisation, transient ischaemic attack/stroke, peripheral vascular disease, heart failure and cardiac arrhythmia 2. Suffering from cancer or chronic kidney disease 3. Currently prescribed with statins, exetimibe and pcsk-9 inhibitors to treat cholesterol levels 4. Been told by a doctor that they should only do physical activity recommended by a doctor due to a heart condition 5. Serious mental illness (Eg. A patient who is suffering from serious mental illness refers to those who need assistance in daily activities due to their mental illness.) 6. The following groups of individuals will be excluded as most of them would require pharmacological therapy for risk factors based on clinical guidelines in Singapore: * Diagnosed with diabetes * For those with FRS of 5-9%, LDL ≥160mg/dL * For those with FRS of 10-19%, LDL ≥130mg/dL * For those with FRS of ≥20%, LDL ≥100mg/dL * Total cholesterol \>280 mg/dL at the point of screening * Systolic blood pressure \>160 mmHg at the point of screening * Triglycerides ≥4.5 mmol/L 7. Pregnant or planning to be pregnant in the next 7 months 8. Unable to give informed consent 9. Current or previous participants in HOPE Pilot Study, or HOPE-CVD-GP study 10. Members of the same household or family of existing enrolled participants
Trial Sites
Countries
This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service