Machine Learning Approaches to Personalized Therapy for Advanced Non-small Cell Lung Cancer With Real-World Data

Inclusion Criteria

Inclusion Criteria Subjects must meet all of the following eligibility criteria: * Diagnosed with advanced NSCLC between January 1, 2011, and June 30, 2024. * Follow-up available until December 31, 2024, with a minimum potential follow-up period of at least six months. Exclusion Criteria Subjects meeting any of the following criteria at baseline will be excluded: * Fewer than one day of follow-up post-initiation of first-line (1L) therapy. * Presence of a targetable mutation, including ALK, BRAF, EGFR, KRAS, or ROS1. * PD-L1 expression \<50% at baseline (restricted to patients with PD-L1 ≥50%). * First-line treatment limited to immunotherapy or chemoimmunotherapy (excluding other treatment regimens). * Patients receiving second-line (2L) treatment, including those enrolled in a clinical study.