Longitudinal Frontal EEG Trajectories Reveal Divergent Cortical Dynamics in Delirium After Severe Trauma
Sponsor: Ajou University School of Medicine
Trial Details
| Condition | Delirium, Trauma, Brain Dysfunction, Critical Illness |
| Status | Completed |
| Participants | 73 |
| Est. Completion | 27 Apr 2025 |
| Last Updated | 17 Apr 2026 |
Primary Outcome
Predictive Performance for Delirium (Area Under the Receiver Operating Characteristic Curve, AUROC
Eligibility Criteria
Inclusion Criteria
1. Inclusion Criteria: Trauma patients admitted to the Trauma Intensive Care Unit (TICU) who meet the following criteria: * Patients aged 18 to 65 years. * Severe trauma patients with an Injury Severity Score (ISS) 2. Exclusion Criteria: Patients with a head Abbreviated Injury Scale (AIS) ≥ 2 Patients with a Richmond Agitation-Sedation Scale (RASS) score ≤ -2 History of neurological disorders (e.g., Parkinson's disease, dementia, cerebrovascular disease) History of major psychiatric disorders (e.g., schizophrenia, bipolar disorder, intellectual disability, autism spectrum disorder) History of illicit drug use disorder or positive results on a urine drug screen for substances other than Benzodiazepines or Tricyclic antidepressants. Clinical evidence of acute alcohol withdrawal (CIWA-Ar score \> 10) History of liver failure or hepatic encephalopathy (Child-Pugh Class B or C) Renal impairment requiring renal replacement therapy (RRT) Inability to perform the Confusion Assessment Method for the ICU (CAM-ICU) due to the following Inability to communicate in Korean Failure to obey commands (unable to follow test instructions) Severe visual or hearing impairment Refusal to undergo CAM-ICU assessment Requirement for isolation due to infectious diseases (e.g., COVID-19, active tuberculosis).
Trial Sites
Countries
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