Predictors Of Cognitive Decline In Attenders Of Essex Memory Clinic From Digital Devices Using Classical Statistical Methods, Machine Learning And Disease Progression Modelling

Inclusion Criteria

Inclusion Criteria: 1. Patients who present to the Essex Memory Clinic and their relatives or carers 2. Capacity to provide written informed consent 3. Sufficient proficiency in English to understand study documents and use the digital devices 4. Own a compatible smartphone (Android 7.0 or higher / iOS 12.2 or higher). If participants own a smartphone which is not a compatible device (i.e. prior to Android 7.0 or iOS 12.2), a new handset will be provided to them, as long as they are willing to use this as their primary phone. 5. Ability to use a smartphone and EDoN digital devices, either alone, or with appropriate support (carer, partner, family member, etc). Support would involve reminding participants to complete study tasks and to charge / wear devices. 6. Able to connect to the internet using their smartphone at home. Note: In order to use the Dreem headband, participants will additionally require a home WiFi connection. However, participants without a WiFi connection will still be able to join the study and will not be asked to use the Dreem headband. 7. For people with a diagnosis of dementia, a carer, partner or family member willing to support their participation in the study by reminding patients to complete study tasks and to charge/wear their devices 8. For patients who do not have a record of neurocognitive and physical assessments outlined in section 4.5.3, they must be willing to undergo these additional assessments 9. For the blood donation sub study only: consented to participate in the main CODEC II study. 10. For the qualitative sub study only: able to use a phone or video-conferencing platform to participate in the interviews 11. Aged 40+ years Exclusion Criteria: 1. Patients with active major psychiatric disorder which requires regular reviews by secondary care, for example schizophrenia, schizoaffective disorder or bipolar affective disorder 2. Patients under end-of-life care 3. Previous sensitivity or allergic skin reaction to latex, rubber or plastics 4. Do not have a personal smartphone with internet access 5. Participating in a clinical trial of an investigational medicinal product 6. Not meeting all inclusion criteria