Development and Validation of a Multimodal Artificial Intelligence Model Integrating CT Radiomics, Pathomics, and Clinical Features for the Diagnosis, Risk Stratification, and Genotype Prediction of Gastrointestinal Stromal Tumors

Inclusion Criteria

Inclusion Criteria: Age ≥ 18 years, gender not limited. Clinical diagnosis of gastric submucosal tumor (SMT) or suspected gastrointestinal stromal tumor (GIST) based on gastroscopy or ultrasound. Scheduled for surgical resection or endoscopic biopsy at the study center. Standard preoperative contrast-enhanced CT scans are available (performed within 2 weeks prior to surgery). Patients or their legal guardians have signed the informed consent form. Exclusion Criteria: Received neoadjuvant therapy (e.g., Imatinib, chemotherapy, or radiotherapy) prior to surgery/biopsy. Poor quality of CT images (e.g., severe motion artifacts) affecting radiomics analysis. Insufficient tissue samples for pathological diagnosis or genetic testing. Confirmed diagnosis of other primary malignancies. Incomplete clinical data or lost to follow-up immediately after surgery.