Pulse Wave Velocity and Machine Learning for Prediction of Coronary Artery Disease by Coronary CT Angiography - The Heart Waves Study
Sponsor: Danderyd Hospital
Trial Details
| Condition | Coronary Artery Disease, Chest Pain, Dyspnea, Arterial Stiffness |
| Intervention | Coronary computer tomography angiography (CCTA); Photoplethysmography (PPG) and single-lead ECG; Brachial single cuff-based arterial stiffness |
| Status | Terminated |
| Participants | 156 |
| Est. Completion | 1 July 2025 |
| Last Updated | 17 Apr 2026 |
Primary Outcome
Improved area under receiver operating curve (ROC) to predict CAD-RADS ≥3
Eligibility Criteria
Inclusion Criteria
Inclusion Criteria: * Patients undergoing coronary computer tomography angiography to investigate stable suspected symptomatic coronary artery disease. * Age 30 to \<70 years of age. Exclusion Criteria: * Known coronary artery disease (prior myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft or any angiographic evidence of coronary artery disease ≥50% lesion in a major epicardial vessel). * Known significant cardiac (\> moderate valvular disease, heart failure with reduced ejection fraction, hypertrophic cardiomyopathy, or congenital heart disease), or pulmonary condition which could explain symptoms. * Known ongoing atrial fibrillation/flutter. * No Swedish social security number. * Unable to provide written informed consent.
Trial Sites
Countries
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