Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure
Sponsor: Brigham and Women's Hospital
Trial Details
| Condition | Heart Failure |
| Intervention | LLM-GDMT Clinical Decision Support Tool |
| Phase | NA |
| Status | Not_yet_recruiting |
| Participants | 500 |
| Est. Completion | 1 July 2027 |
| Last Updated | 21 Apr 2026 |
Primary Outcome
Any GDMT optimization within 30 days of index visit
Eligibility Criteria
Inclusion Criteria
Inclusion Criteria: * Age ≥18 years * Scheduled outpatient visit with a participating cardiology provider in an MGB outpatient cardiology clinic * At least one prior cardiology clinic visit in the MGB system within the past 2 years * Diagnosis of heart failure by ICD code within the past 2 years * Heart failure diagnosis supported by at least one of the following: * Current or recent use of a loop diuretic * Left ventricular ejection fraction ≤40% on the most recent echocardiogram * Explicit documentation of heart failure diagnosis or heart failure signs/symptoms in a prior cardiology note Exclusion Criteria: * Systolic blood pressure \<90 mmHg on the most recent recorded measurement * Heart rate \<50 beats per minute on the most recent recorded measurement * eGFR \<20 mL/min/1.73 m² on the most recent laboratory assessment * Known cardiac amyloidosis or hypertrophic cardiomyopathy * History of heart transplant or presence of a left ventricular assist device * Severe aortic stenosis, severe aortic insufficiency, or severe mitral stenosis on the most recent echocardiogram * Encounter occurs in an adult congenital heart disease clinic
Trial Sites
Countries
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