Research Appraisals
Evidence-based critical appraisals of the latest medical research, systematically evaluated using Oxford CEBM methodology.
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Proceedings of the National Academy of Sciences of the United States of America
Legal infrastructure for transformative AI governance
Most of our AI governance efforts focus on substance: What rules do we want in place? What limits or checks do we want to impose on AI development and deployment? But a key role for law is not only to establish substantive rules but also to establish legal and regulatory infrastructure to generate and implement rules. The transformative nature of AI calls especially for attention to building legal and regulatory frameworks. In this Perspective, I review three examples: the creation of registration regimes for frontier models; the creation of registration and identification regimes for autonomous agents; and the design of regulatory markets to facilitate a role for private companies to innovate and deliver AI regulatory services.
29 July 2026
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Internet of Things-Enhanced Mathematical Oncology: Conceptual Framework for Adaptive Cancer Care Modeling
The Internet of Things (IoT) is transforming various industries, including health care. IoT-based systems are increasingly prevalent in consumer health applications, while intelligent or smart devices equipped with sophisticated sensors are gaining recognition for their potential to improve clinical care practice and decision-making. Cancer care is a particularly promising area for IoT applications, enabling real-time and personalized interventions. However, empirical research on the effects of IoT in this field is limited due to the complexities inherent in cancer as a dynamic disease and the paucity of IoT-generated data available for research. This presents an opportunity to apply mathematical modeling to understand the effects of IoT under various scenarios. These analytical and "in silico" mathematical approaches are instrumental with limited data. Such models support the analysis of treatment uncertainty and patient response while balancing patient preferences, clinical outcomes, and system-level constraints. Grounded in mathematical oncology and health informatics, this paper proposes a conceptual framework that integrates real-time IoT data as dynamic inputs into adaptive mathematical models to simulate cancer dynamics. By exploring applications across multiple levels of analysis, the study demonstrates how IoT-enhanced mathematical models could inform implementation and optimize oncology services, addressing a critical gap in current research.
15 July 2026
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