Research Appraisals
Evidence-based critical appraisals of the latest medical research, systematically evaluated using Oxford CEBM methodology.
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ACS applied materials & interfaces
Fingerprint-Inspired Recyclable Electronic Skin for Non-Contact Urinary Incontinence Monitoring and Sensing
The development of high-performance flexible electronics faces a fundamental challenge: balancing sophisticated multimodal sensing and end-of-life environmental sustainability. Drawing inspiration from the human fingerprint, we present a microelectronic-printing-based arch-shaped sensor that resolves this conflict by integrating dual-mode (contact/non-contact) sensing with inherently recyclable components. The device, fabricated through high-resolution printing of liquid metal circuits (with line widths below 200 μm) on functionally tailored substrates, exhibits a sensitivity of 3.07 kPa-1 and a response time under 60 ms. It operates across a broad pressure range (0-15 kPa) in contact mode and senses proximity up to 5 cm. This robust performance enables an integrated wireless system for encrypted communication, gesture-trajectory tracking, and dynamic gesture recognition with 92.67% classification accuracy. Notably, we demonstrate a closed-loop lifecycle for the key functional materials, achieving 86.2% recovery and direct reuse of the liquid metal conductor. This work provides a versatile design strategy that simultaneously meets the demands for performance, functionality, and sustainability, offering a practical platform for future green and intelligent wearable technologies.
3 May 2026
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Randomized trial of transcutaneous tibial nerve stimulation to treat overactive bladder in older women
OBJECTIVES: To evaluate the effects of transcutaneous tibial nerve stimulation (TTNS) associated with behavior therapy (BT) compared to BT alone in the treatment of Overactive Bladder Syndrome (OAB) in older women. STUDY DESIGN: Randomized controlled clinical trial in two groups, G1 that received BT (n = 19) and G2 with the addition of TTNS (n = 19). MAIN OUTCOME MEASURES: The variables analyzed were impact on quality of live (QOL) and degree of discomfort of the symptoms of OAB by International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and voiding habit by a 3-day voiding diary (VD). The assessments were conducted at the beginning and the end of the treatment. RESULTS: Both groups showed a significant reduction in the impact of QOL by ICIQ-OAB. The G1 (BT) reduced the discomfort of nocturia symptoms and urgency urinary incontinence, while in G2 (BT+TTNS), it just did not present a reduction in the discomfort of urinary frequency by ICIQ-OAB. In the VD, despite G1 presenting an episode reduction of urgency urinary incontinence and nocturia, it showed no significant difference. In the G2, the same variables had significant reduction. CONCLUSION: Behavioral therapy reduced OAB symptoms and discomfort in older women, but its combination with TTNS led to greater improvements, particularly in urgency and nocturia. TTNS was safe, well tolerated, and enhanced quality of life, although further studies with larger samples and longer follow-up are warranted. No adverse events or complications were observed, supporting the safety and tolerability of TTNS in older women with OAB.
7 Apr 2026
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