Evidence-Based Medicine

Research Appraisals

Evidence-based critical appraisals of the latest medical research, systematically evaluated using Oxford CEBM methodology.

Showing 6 appraisals

observationalEvidence: Moderate
85CEBM

Proceedings of the National Academy of Sciences of the United States of America

Speed and quality of complex strategic decisions

Many strategic decisions involve both substantial complexity and time pressure, but the association between decision speed and decision quality of cognitively demanding strategic decisions is not well understood. This paper presents evidence on this question using a setting with exceptionally detailed and precise information about decision times and decision quality-it analyses move-by-move data from in-person professional chess tournaments. Decision quality is measured by comparing actual moves to a computational benchmark of best moves constructed using the artificial intelligence of a chess engine. The results show that faster decisions are associated with higher decision quality, even after accounting for computational complexity, distinctiveness between alternatives, and time pressure. Greater computational complexity and lower distinctiveness between move alternatives are associated with longer decision times, whereas greater time pressure is associated with shorter decision times. All three factors are associated with lower decision quality. We discuss the findings against the predictions of different decision models in which individuals sequentially acquire information about alternatives with uncertain valuations, extending theories originally developed in the context of nonstrategic decisions to a strategic environment.

15 May 2026

Read appraisal →
otherEvidence: Moderate
80CEBM

Behavior research methods

Lexique 4: A major upgrade of the Lexique French lexical database

Lexique 4, an updated French lexical database, expands upon its predecessor, Lexique 3, by incorporating several significant improvements to enhance its utility in psycholinguistics, computational linguistics, and education. The new version is based on a larger corpus of 316 million words derived from 65,317 documents, including movie, TV show, and documentary subtitles, which offers more accurate frequency estimates and includes contemporary neologisms. Lexique 4 introduces new variables, such as orthographic surface frequency, contextual diversity (CD), and detailed morphological structure, which provide a more comprehensive view of lexical properties. We find that contextual diversity is a slightly better predictor than word frequency, in line with previous work. Moreover, the integration of lexical decision times from the French Lexicon Project into Lexique 4 facilitates more in-depth linguistic research. Enhancements to the user interface, including a redesigned web platform, enable dynamic searches and sorting capabilities, increasing accessibility and usability for researchers. Statistical analyses indicate that the updated frequency measures in Lexique 4 are better predictors of lexical decision times compared to Lexique 3, supporting the value of these enhancements. Overall, Lexique 4 represents a comprehensive and flexible tool for analyzing French lexical properties, making it an essential asset for a broad range of users.

27 Apr 2026

Read appraisal →
Systematic ReviewEvidence: Moderate
60CEBM

Journal of the International Society of Sports Nutrition

Effects of nutritional interventions on competitive performance and dose‒response relationships among esports players of different skill levels: a systematic review and three-level meta-analysis

BACKGROUND AND OBJECTIVES: Esports place exceptional demands on neuropsychological capacities; however, a systematic and quantitative synthesis of the specific efficacy of nutritional interventions across various tasks and competitive populations remains absent. This study aims to evaluate the impact of nutritional supplementation on cognitive function and competitive performance in esports players and to explore key moderating variables. METHODS: Electronic databases, including Web of Science, PubMed, and Scopus, were searched (up to January 25, 2026). Thirteen randomized controlled trials (RCTs) met the inclusion criteria. A three-level random-effects model was employed to calculate the pooled effect size (Hedges' g), with sources of heterogeneity explored through subgroup analyses and meta-regression. RESULTS: Nutritional interventions significantly enhanced esports-related performance (g = 0.92), with the most pronounced benefits observed in processing speed (g = 1.18) and executive function (g = 1.06). Subgroup analyses revealed significant gains in both professional (g = 0.97) and amateur groups (g = 0.92), while the improvement in first-person shooter (FPS) games (g = 0.96) appeared to surpass that in multiplayer online battle athlete (MOBA) games. Meta-regression indicated no significant linear correlation between caffeine dosage and effect size. GRADE assessment categorized the quality of evidence mostly as "low" to "moderate." CONCLUSIONS: Nutritional interventions demonstrate significant potential for optimizing multidimensional cognitive performance in esports players, particularly in enhancing fundamental reaction speed and high-level decision-making processes. While the findings exhibit a degree of robustness, their practical application should be cautiously evaluated within specific competitive contexts due to current limitations in evidence certainty and significant interstudy heterogeneity. Future research characterized by gender balance and mechanistic orientation with long-term intervention protocols is warranted to elevate the level of clinical evidence.

27 Apr 2026

Read appraisal →
otherEvidence: Moderate
60CEBM

Psychonomic bulletin & review

Speaker effects in language comprehension: An integrative model of language and speaker processing

The identity of a speaker influences language comprehension through modulating perception and expectation. This review explores speaker effects and proposes an integrative model of language and speaker processing that integrates distinct mechanistic perspectives. We argue that speaker effects arise from the interplay between bottom-up perception-based processes, driven by acoustic-episodic memory, and top-down expectation-based processes, driven by a speaker model. We show that language and speaker processing are functionally integrated through multi-level probabilistic processing: prior beliefs about a speaker modulate language processing at the phonetic, lexical, and semantic levels, while the unfolding speech and message continuously update the speaker model, refining broad demographic priors into precise individualized representations. Within this framework, we distinguish between speaker-idiosyncrasy effects arising from familiarity with an individual and speaker-demographics effects arising from social group expectations. We discuss how speaker effects serve as indices for assessing language development and social cognition, and we encourage future research to extend these findings to the emerging domain of artificial intelligence (AI) speakers, as AI agents represent a new class of social interlocutors that are transforming the way we engage in communication.

17 Apr 2026

Read appraisal →
Systematic ReviewEvidence: Moderate
75CEBM

NeuroImage

Convergent neural signatures of optimal creative performance: A systematic review and meta-analysis

The neural architecture that supports optimal creative performance across diverse contexts remains unclear. To address this question, we conducted a quantitative meta-analysis to identify convergent patterns of brain activation associated with enhanced creativity and to examine their relationships with behavioral improvements. A total of 33 neuroimaging studies involving 965 participants were included, encompassing four enhancement contexts: creativity training, domain-specific expertise, trait-level creativity, and positive stimulus conditioning. Across these contexts, superior creative performance (Hedges' g = 0.668) was consistently characterized by increased activation in the left middle frontal gyrus (LMFG), left superior frontal gyrus (LSFG), and left inferior parietal gyrus (LIPG), together with decreased activation in the right precuneus (95 % CI [0.508, 0.828]). Meta-regression analyses revealed that longer intervention duration and greater professional experience predicted stronger LSFG and LIPG activation, whereas age and sex ratio showed no significant effects. LSFG activation was attenuated during convergent thinking tasks, suggesting task-specific modulation of creative neural circuits. These findings provide systematic evidence for a convergent neural signature of superior creative performance across multiple enhancement pathways, offering empirical targets for future training and neuromodulation-based interventions to optimize creative potential.

17 Apr 2026

Read appraisal →
observationalEvidence: Moderate
75CEBM

Journal of speech, language, and hearing research : JSLHR

Information Load Predicts Stuttering Events

PURPOSE: One potential contributor to the variability of stuttering events is information load, quantified by assessing word predictability based on preceding context. This study investigated whether words with greater information load are more likely to be stuttered using word surprisal as an index while controlling for relevant linguistic variables. We also examined whether this relationship varied with stuttering severity and impact. METHOD: We analyzed spontaneous speech samples from 35 adults who stutter, drawn from the FluencyBank corpus. Word surprisal values were computed using the Generative Pretrained Transformer 2 large language model and analyses controlled for six linguistic predictors of stuttering. We also tested whether clinical measures of stuttering severity and overall impact predicted individuals' sensitivity to surprisal. RESULTS: Higher word surprisal significantly increased the likelihood of stuttering, even after controlling for linguistic covariates. However, we found no evidence that stuttering severity or overall impact moderated this relationship. CONCLUSIONS: These findings suggest that words with greater information load are more likely to elicit stuttering during spontaneous speech. This pattern may reflect increased communicative demands associated with high-surprisal words. The absence of a moderating effect of stuttering severity or impact may indicate that individual differences in coping with communicative pressure, rather than clinical severity alone, shape stuttering variability.

11 Apr 2026

Read appraisal →