Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis.

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: 21.3% of placebo group achieved sustained off-treatment control

• Primary Outcome: Off-treatment disease control (no flare for 40 weeks)

• Nnt Or Sensitivity: Approximately 5 patients need initial abrocitinib treatment for 1 to achieve sustained off-treatment remission

• Confidence Interval: Not reported

Clinical Application

Feasible in Australian dermatology practice with appropriate monitoring protocols for JAK inhibitor withdrawal Relevant to PBS-subsidised abrocitinib use; supports treatment discontinuation strategies in responders, potentially reducing long-term medication costs and monitoring requirements Adults and adolescents with moderate-to-severe atopic dermatitis who achieve good initial response to JAK inhibitor therapy

Abstract

PURPOSE: Achieving sustained on- and off-treatment disease control is an important therapeutic goal in atopic dermatitis (AD). This study evaluated achievement of off-treatment disease control in patients randomized to placebo following 12 weeks of abrocitinib 200 mg. MATERIALS AND METHODS: In the phase 3 JADE REGIMEN study, patients with moderate-to-severe AD who achieved Investigator's Global Assessment (IGA) of 0/1 (with ≥2 grades of improvement) and ≥75% improvement in Eczema Area and Severity Index (EASI) after 12 weeks of abrocitinib 200 mg were randomized (1:1:1) to placebo, abrocitinib 100 mg, or abrocitinib 200 mg for 40 weeks. This post-hoc analysis evaluated patients by flare status (protocol flare definition: ≥50% loss of initial EASI post-randomization response and IGA score ≥2). EASI, IGA, Peak Pruritus Numerical Rating Scale (PP-NRS), and Dermatology Life Quality Index (DLQI) were evaluated. RESULTS: There were no off-treatment flares in 21.3% of patients in the placebo arm. The no-flare group had EASI, IGA, PP-NRS, and DLQI mean scores indicating clear/mild AD at week 52 (2.9, 1.0, 2.6, and 3.5, respectively). CONCLUSIONS: After 12 weeks of abrocitinib 200 mg, some patients achieved 40 weeks of sustained off-treatment disease control, with assessments demonstrating clear/mild AD, suggesting attainment of disease remission. TRIAL REGISTRATION: NCT03627767.

References

1. 1.Guttman-Yassky, E., Bieber, T., Kabashima, K., Gutermuth, J., Weidinger, S., Wollenberg, A., Lazariciu, I., Encinas, G., Mikheil, M., & Watkins, M. (2026). Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis. The Journal of Dermatological Treatment. https://doi.org/10.1080/09546634.2026.2672328