Mycobacterium tuberculosis Transmission in Healthcare Settings: A Systematic Review of Frequency, Risk Factors, and Exposure Conditions

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: Transmission rates varied by risk factors: 12.1% without N95 respirators, 45.1% with frequent direct care, 33.6% without negative pressure ventilation

• Primary Outcome: Overall tuberculosis transmission rate of 7.1% in healthcare settings

• Nnt Or Sensitivity: Only 6.9% of transmissions occurred with <8 hours cumulative exposure, suggesting 8-hour threshold has high sensitivity for identifying transmission risk

• Confidence Interval: Not reported

Clinical Application

Highly feasible - recommendations align with existing infection control infrastructure and PPE availability Directly applicable to Australian healthcare settings. Supports current NHMRC and state health department TB infection control guidelines. Relevant for TGA-approved N95 respirators and hospital ventilation standards under Australian building codes Healthcare workers and patients in acute care, emergency departments, and inpatient settings with potential TB exposure

Abstract

BACKGROUND: Uncertainty regarding factors that govern Mycobacterium tuberculosis transmission in healthcare settings leads to broad and variable exposure definitions and low-yield contact investigations. We systematically reviewed data on M. tuberculosis transmission in healthcare to inform risk stratification and exposure definitions. METHODS: We searched MEDLINE, Embase, CINAHL, and Cochrane databases from inception through December 2024 for studies describing M. tuberculosis transmission from adult patients to healthcare personnel (HCP) or patients. We tabulated data on transmission frequency, circumstances, and risk factors. RESULTS: Of 6695 studies screened, 86 met inclusion criteria, encompassing 1083 source patients, 35 698 exposed individuals, and 2517 secondary cases (7.1% overall transmission risk, 3.8% among studies published since the US Centers for Disease Control and Prevention last updated healthcare ventilation standards in 2005). Transmission was associated with prolonged contact between HCP and source patients (median duration 24 hours, interquartile range [IQR] 24-25 hours) and between patients in shared rooms (median duration 24 hours, IQR 12-24 hours), clinical care without N95 respirator (1232 transmissions/10 149 exposures that included data on face covering use, 12.1%), frequent direct care (185 transmissions/410 exposures, 45.1%), and lack of negative pressure ventilation (1906 transmissions/5670 exposures, 33.6%). Only 8/116 (6.9%) transmissions with documented exposure durations were associated with <8 hours of cumulative exposure and all in poorly ventilated spaces. CONCLUSIONS: Mycobacterium tuberculosis transmission in healthcare is uncommon, particularly in spaces that meet current healthcare ventilation standards. Risk factors for transmission include prolonged exposure, close contact, lack of respirators, and poor ventilation. Defining exposures as >8 hours without a respirator should identify most transmissions and could improve the efficiency of contact investigations.

References

1. 1.Manzoor, F., Rhee, C., Baker, M. A., & Klompas, M. (2026). Mycobacterium tuberculosis transmission in healthcare settings: A systematic review of frequency, risk factors, and exposure conditions. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciag053