Multidimensional psychological and neurophysiological effects of moderate- and low-intensity exercise on pregnant women: an integrative systematic review and Bayesian framework network meta-analysis

Clinical Snapshot

Key Findings

• P Value: Not reported in abstract

• Effect Size: Moderate-intensity aerobic training SUCRA = 0.89 for depression; Yoga SUCRA = 0.76 for anxiety

• Primary Outcome: Prenatal depression and anxiety reduction

• Nnt Or Sensitivity: Interventions ≥3 times/week for >12 weeks showed larger effect sizes

• Confidence Interval: Not explicitly reported in abstract

Clinical Application

High - exercise interventions are accessible and safe during pregnancy Aligns with RACGP pregnancy care guidelines promoting physical activity; could inform Medicare-funded antenatal care programs Pregnant women seeking non-pharmacological mental health interventions

Abstract

BACKGROUND: Pregnancy-related mental health disorders are an increasingly important global public health concern. Exercise interventions have gained attention as safe, non-pharmacological strategies for improving maternal psychological and neurophysiological well-being. However, comparative evidence regarding different exercise modalities and intensities remains limited. OBJECTIVE: This study aimed to systematically evaluate and rank the effects of different prenatal exercise modalities and compare moderate- versus low-intensity exercise protocols on maternal mental health and neurophysiological outcomes during pregnancy. METHODS: A Bayesian network meta-analysis was conducted following PRISMA-NMA guidelines. PubMed, Embase, Cochrane Central, and PsycINFO were systematically searched. Thirty-six randomized controlled trials involving 4,577 pregnant participants were included. Methodological quality was assessed using the Cochrane RoB 2.0 tool. Treatment effects were ranked using the surface under the cumulative ranking curve method. RESULTS: Moderate-intensity aerobic training showed the strongest effect on reducing prenatal depression, with a SUCRA value of 0.89. Yoga-based interventions were particularly effective for anxiety reduction, with a SUCRA value of 0.76, and ranked second in the overall outcome evaluation, with a SUCRA value of 0.82. Neurophysiological findings indicated that yoga showed the greatest benefit for cortisol regulation, whereas aquatic exercise demonstrated distinctive anti-inflammatory effects. Subgroup analyses suggested that moderate-intensity exercise tended to produce greater reductions in depression, while low-intensity exercise showed comparable or superior effects on anxiety and cortisol modulation. Meta-regression further indicated that interventions conducted three times per week and lasting more than 12 weeks were associated with larger effect sizes. The certainty of evidence ranged from moderate to high across primary comparisons. CONCLUSION: This network meta-analysis provides a preliminary evidence hierarchy for prenatal exercise interventions. Moderate-intensity aerobic exercise may be most beneficial for reducing prenatal depression, while yoga appears particularly suitable for anxiety and cortisol regulation. These findings offer clinicians a reference framework for individualized prenatal exercise recommendations and support the integration of exercise into maternal mental healthcare.

References

1. 1.He, L., Wang, S., Cao, Y., Wang, B., Liu, H., Zhang, J., Xu, F., & Jiao, J. (2026). Multidimensional psychological and neurophysiological effects of moderate- and low-intensity exercise on pregnant women: an integrative systematic review and Bayesian framework network meta-analysis. Archives of Women's Mental Health. https://doi.org/10.1111/cns.13385