Research Appraisalother

Levels of analysis for large language models

Philosophical transactions. Series A, Mathematical, physical, and engineering sciencesKu, Alexander, Campbell, Declan, Bai, Xuechunzi et al.14 May 2026DOI

Clinical Snapshot

70CEBM
Evidence: Moderateother

PICO Framework

P — PopulationLarge language models and artificial intelligence systems
I — InterventionApplication of cognitive science methods using Marr's levels of analysis framework
C — ComparatorTraditional approaches to understanding AI systems
O — OutcomesFramework for understanding behaviour and internal organization of large language models

Bottom Line

This theoretical paper proposes applying David Marr's cognitive science framework to understand large language models through three levels of analysis: computational, algorithmic, and implementational. While not directly clinical, this work is relevant to healthcare professionals as AI systems become increasingly integrated into medical practice. The framework could inform how we evaluate and understand AI diagnostic tools, clinical decision support systems, and other healthcare AI applications. However, the work remains theoretical without empirical validation. For Australian healthcare, this contributes to the broader understanding needed for TGA evaluation of AI medical devices and development of appropriate governance frameworks for AI in clinical settings.

Evidence: Moderate

Key Findings

  • Effect Size: Not applicable - theoretical work

  • Primary Outcome: Theoretical framework for understanding large language models using cognitive science methods

  • Nnt Or Sensitivity: Framework applicability across multiple AI research domains

Clinical Application

High feasibility for research applications, limited direct clinical implementation Relevant to Australian AI research initiatives and TGA considerations for AI in healthcare, though not directly applicable to clinical practice guidelines AI researchers, cognitive scientists, and healthcare professionals working with AI systems

Abstract

Modern artificial intelligence systems, such as large language models, are increasingly powerful but also increasingly hard to understand. Recognizing this problem as analogous to the historical difficulties in understanding the human mind, we argue that methods developed in cognitive science can be useful for understanding large language models. We propose a framework for applying these methods based on the levels of analysis that David Marr proposed for studying information processing systems. By revisiting established cognitive science techniques relevant to each level and illustrating their potential to yield insights into the behaviour and internal organization of large language models, we aim to provide a toolkit for making sense of these new kinds of minds. This article is part of the theme issue 'World models in natural and artificial intelligence'.

References

  1. 1.Ku, A., Campbell, D., Bai, X., Geng, J., Liu, R., Marjieh, R., McCoy, R. T., Nam, A., Sucholutsky, I., Zhang, L., Zhu, J. Q., & Griffiths, T. (2026). Levels of analysis for large language models. Philosophical Transactions of the Royal Society A, 384(2274). https://doi.org/10.1098/rsta.2025.0012
Share:XLinkedIn

This content is for educational purposes for healthcare professionals only and does not constitute clinical advice. Clinical decisions should be based on individual patient assessment, current guidelines, and appropriate specialist consultation. Editorial Standards · Privacy Policy · Terms of Service