LADNET: An MRI-based deep learning approach for Alzheimer's disease detection.

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: 99.4% overall accuracy

• Primary Outcome: Multi-class classification accuracy for dementia staging

• Nnt Or Sensitivity: 99% AUC (area under curve), class-specific sensitivity/specificity not reported

• Confidence Interval: Not reported

Clinical Application

Technically feasible with standard MRI equipment, but clinical integration requires regulatory approval Would require TGA approval as medical device software; needs validation against Australian dementia diagnostic guidelines and integration with existing neuroimaging protocols Limited applicability - requires validation in clinical populations with suspected dementia

Abstract

Alzheimer's disease (AD) is considered a leading form of dementia, found in the majority of individuals, and it accounts for the highest prevalence of all the types of dementia. It is a gradually progressing condition which can begin with mild memory impairment and may lead to the inability to engage in meaningful conversations in the future. In addition to that, it is also capable of reacting appropriately to the environment around it. According to official data, there has been an increase in reported cases of AD-related mortality in recent years, along with rising rates of the disease itself. Therefore, it is beneficial for patients to be diagnosed with AD as early as possible in order to maximize their chance of survival. In medical field, deep learning (DL) is employed in many applications, especially the identification of Alzheimer's disease, has shown considerable success. Based on the fact that these methods are capable of acquiring and extracting features from extensive datasets autonomously, they are highly suitable for analyzing intricate medical images with the aid of these methods. Design the Lightweight Alzheimer's Disease Net (LADNET) model for the current task. Accurate detection of AD using magnetic resonance imaging (MRI)-based scans is presented in this work. The model classifies the three dementia types, namely Mild Dementia (MD), Moderate Dementia (MDD), and Very Mild Dementia (VMD), while also accurately categorizing the non-demented (ND) category based on the severity of the condition. We measure the performance of the model we recommend against a publicly available Kaggle dataset that contains over six thousand images from four different types of images. LADNET model achieves 99.4% accuracy and 99% AUC, outperforming existing methods. With a lightweight design of approximately 1.2 million parameters and fast inference (4.2 ms per image), LADNET demonstrates strong potential for practical clinical deployment, where it could help extract biomarker information from conventional MRIs, potentially reducing patient burden and diagnostic costs.