Research Appraisalother

Implementation of dispense waste functionality with new electronic health record system.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System PharmacistsBaumann, Alysa, Fitzpatrick, Nicole, Fitzgerald, Diana et al.22 Apr 2026DOI

Clinical Snapshot

60CEBM
Evidence: Moderateother

PICO Framework

P — PopulationHospital pharmacy staff at a pediatric research hospital implementing electronic health record system for medication waste documentation
I — InterventionImplementation of dispense waste functionality in electronic health record system with staff training and process changes
C — ComparatorPre-implementation waste documentation practices (baseline measurement)
O — OutcomesReal-time waste documentation compliance rates during drug preparation, measured as percentage of waste documented at time of medication preparation

Bottom Line

This single-site implementation study demonstrates that combining electronic health record functionality with staff training can substantially improve real-time medication waste documentation compliance from 31% to 86% over 8 months. While the results show statistical significance and a large effect size, the study's before-and-after design without a control group limits causal inference. The intervention addressed US regulatory requirements for JZ modifier reporting, but the general approach of systematic waste documentation has broader applicability. Australian hospitals could adapt these methods for PBS compliance and medication stewardship programs, though the specific regulatory context differs. The study provides useful implementation guidance but would benefit from replication in diverse hospital settings with more rigorous study design including control groups and confidence interval reporting.

Evidence: Moderate

Key Findings

  • P Value: P < 0.001

  • Effect Size: Increase from 31.1% to 85.9% (54.8 percentage point improvement)

  • Primary Outcome: Real-time waste documentation compliance during drug preparation

  • Nnt Or Sensitivity: Absolute risk reduction of 54.8% suggests approximately 2 staff members need training for 1 to achieve compliant documentation

  • Confidence Interval: Not reported

Clinical Application

Requires electronic health record system capability, dedicated pharmacy technician time for retrospective review, and ongoing staff education programs Relevant for Australian hospitals implementing PBS compliance measures and medication waste reduction initiatives, though specific JZ modifier requirements are US-specific. Principles applicable to TGA reporting requirements and hospital accreditation standards Hospital pharmacy departments implementing electronic health record systems for medication waste tracking, particularly pediatric hospitals with high single-dose container usage

Abstract

PURPOSE: Practice changes were implemented and adjusted to ensure regulatory compliance with JZ modifier documentation. SUMMARY: The JW modifier allows institutions to bill for partially unused and discarded single-dose containers of drugs and biologics, whereas the JZ modifier is used to report that no amount of drug was discarded from a single-dose container. These modifiers are essential for accurate coding and resource stewardship, especially in pediatric hospitals, where medication doses are often patient specific and require manipulation of single-dose containers. Starting July 1, 2023, the Centers for Medicare & Medicaid Services required providers to report the JZ modifier on all claims that bill for drugs from single-dose containers. Our institution underwent a soft go-live in June 2023, which allowed the institution to make necessary process changes to ensure regulatory compliance. In June 2023, only 31.1% of waste was documented at the time of medication preparation. To capture waste documentation post preparation, a pharmacy technician was trained to review missed opportunities and document waste retrospectively. Monthly monitoring of waste documentation, including missed opportunities during drug preparation, was conducted and further staff education was provided. A reassessment of waste documentation was completed in February 2024, which highlighted that real-time waste documentation completed during compounding had increased to 85.9%. By documenting waste during drug preparation, the resources spent reviewing reports for drug preparations from the previous day and the need to document waste are reduced. CONCLUSION: Through process implementation and staff education, compliance with real-time waste documentation during drug preparation increased from 31.1% to 85.9% (P < 0.001) in 8 months.

References

  1. 1.Baumann, A., Fitzpatrick, N., Fitzgerald, D., & Brasher, C. (2026). Implementation of dispense waste functionality with new electronic health record system. American Journal of Health-System Pharmacy, 83(8), 234-241. https://doi.org/10.1093/ajhp/zxaf334
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