Hybrid deep learning and feature selection approach for autism detection from rs-fMRI data

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: 73% accuracy across three atlas-based feature sets

• Primary Outcome: Diagnostic accuracy for ASD detection

• Nnt Or Sensitivity: Sensitivity: 78%, AUC: 79%

• Confidence Interval: Not reported

Clinical Application

Low feasibility due to requirement for specialized rs-fMRI acquisition and computational resources Not directly applicable to current Australian diagnostic pathways; would require TGA approval and integration with existing RACGP ASD screening protocols Limited to research settings; unclear applicability to routine clinical practice

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that is primarily characterized by deficits in social communication and restricted or repetitive behavioral patterns. Although psychologists contribute significantly to the understanding of ASD, offering insights into its cognitive, emotional, and behavioral dimensions through assessments, diagnoses, therapeutic approaches, and family support, the diagnostic process remains complex. This complexity arises from the diverse manifestations of the disorder and the challenges associated with data sharing. In addition, conventional machine learning approaches for ASD detection may struggle with high-dimensional neuroimaging data and may require careful feature engineering. Consequently, this motivated us to enhance ASD diagnosis by incorporating deep learning (DL) techniques for feature extraction alongside a modified exponential-trigonometric optimization (ETO) algorithm as a feature selection (FS) technique. The modified ETO integrates the Arithmetic Optimization Algorithm (AOA) and the Guided Learning Strategy (GLS) to improve diagnostic performance. To evaluate the effectiveness of the proposed model, we utilized resting-state functional MRI (rs-fMRI) data from the Autism Brain Imaging Data Exchange (ABIDE I). Furthermore, the performance of the proposed model was compared with that of established models. The results indicate that the proposed model achieves competitive and, in most cases, superior performance compared with the benchmark methods, demonstrating superior accuracy, sensitivity, and AUC in diagnosing ASD. On average across the three atlas-based feature sets, the proposed model has an accuracy, sensitivity, and AUC of 73%, 78%, and 79%, respectively.

References

1. 1.Abd Elaziz, M., Mahmoud, N., Ewees, A. A., Khattap, M. G., Dahou, A., Alghamdi, S. M., Nafisah, I., Fares, I. A., & Azmi Al-Betar, M. (2026). Hybrid deep learning and feature selection approach for autism detection from rs-fMRI data. PLoS One. https://doi.org/10.1371/journal.pone.0339921