Research Appraisalother

Evolving Beyond Nature: AI-Driven Rapid Advancements of Bio-Inspired Electronic Skin

ACS applied materials & interfacesQuiquero, Domenic, Noroozi, Reza, Wang, Kaiting et al.8 Apr 2026DOI

Clinical Snapshot

60CEBM
Evidence: Weakother

PICO Framework

P — PopulationNot applicable - this is a narrative review of electronic skin technology
I — InterventionAI-driven approaches to bio-inspired electronic skin design and development
C — ComparatorTraditional electronic skin design approaches
O — OutcomesEnhanced functionality, optimized microstructures, novel applications in healthcare, robotics, and wearable electronics

Bottom Line

This narrative review synthesizes developments in AI-driven bio-inspired electronic skin technology, highlighting potential applications in healthcare monitoring, prosthetics, and rehabilitation. While the technology shows promise for personalized therapeutics and enhanced human-machine interfaces, the review lacks systematic methodology and critical analysis of implementation challenges. The clinical applications remain largely theoretical, with significant technical hurdles including sensitivity, durability, and biocompatibility requiring resolution. Australian clinicians should monitor developments but recognize this represents early-stage technology requiring substantial validation before clinical adoption. The review provides useful background for understanding emerging wearable health technologies but offers limited evidence-based guidance for current practice decisions.

Evidence: Weak

Key Findings

  • Effect Size: Not applicable - narrative review

  • Primary Outcome: Identification of AI-driven approaches accelerating bio-inspired electronic skin development

  • Nnt Or Sensitivity: Not applicable - technology review

Clinical Application

Early-stage technology requiring significant development before clinical implementation Relevant to TGA medical device regulations, potential PBS considerations for future therapeutic applications, and alignment with digital health initiatives Healthcare professionals in rehabilitation, prosthetics, remote monitoring, and wearable device development

Abstract

Electronic skin (e-skin) is a rapidly developing technology at the intersection of humans and machines with tremendous applications in robotics, healthcare, sports performance, and other fields of wearable electronics. With the recent popularization of artificial intelligence (AI), data-driven approaches to materials design and geometric functional optimization have accelerated e-skin development, enabling optimized microstructures, novel functionalities, and improved usability. Recent progress in bioinspired materials design and functionality enhancements for e-skin is paving the way for future-facing machine learning-powered tools to further accelerate their development. In this review, we discuss the traditional properties of e-skins, their sensing mechanisms, and suitable applications. Then, we investigate and categorize bioinspired structures from material, structural, and functional perspectives. Next, we outline the fundamentals of AI for data-driven optimization and how it can be utilized toward bioinspired e-skin design. This blended e-skin design framework culminates in novel applications, from customizable layouts for personalized therapeutics to dynamic environment recognition for enhanced robotics. Finally, we will explore the challenges of e-skin human-machine interfaces, including their hardware limitations, sensitivity, and longevity issues, and offer insights into future-proof research.

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