Effects of oxycodone and sufentanil on the quality of recovery after laparoscopic total hysterectomy: A randomized controlled trial

Clinical Snapshot

Key Findings

• P Value: P = 0.111 for primary outcome

• Effect Size: No clinically significant difference between groups

• Primary Outcome: QoR-40 scores at 24 hours: Group O 170 (156-179) vs Group S 160 (146-178)

• Nnt Or Sensitivity: Not applicable - no significant treatment effect demonstrated

• Confidence Interval: Not reported

Clinical Application

Both medications are readily available and commonly used in Australian anaesthetic practice Both oxycodone and sufentanil are PBS-listed medications. Results support clinical equipoise between these agents for this indication, potentially allowing choice based on other factors such as cost, availability, or patient-specific considerations Women undergoing laparoscopic hysterectomy in Australian hospitals

Abstract

BACKGROUND: To compare the effects of oxycodone and sufentanil on the quality of recovery after laparoscopic total hysterectomy. METHODS: Ninety patients scheduled for laparoscopic total hysterectomy between January and December 2023 were randomly divided into 2 groups: oxycodone group (Group O) and sufentanil group (Group S), with 45 patients in each group. The primary outcome measure was postoperative recovery status recorded using the Quality of Recovery-40 questionnaire. RESULTS: At 24 hours postoperatively, the Quality of Recovery-40 scores of group O and group S were comparable (170 [156-179], 160 [146-178], P = .111). There were no statistically significant differences between the 2 groups in terms of visual analogue scale pain scores at any postoperative time points, postoperative cumulative sufentanil consumption, length of hospital stay, patient satisfaction, and incidence of postoperative nausea and vomiting, and incidence of postoperative dizziness (P > .05). CONCLUSIONS: Oxycodone and sufentanil provide comparable postoperative recovery after total laparoscopic hysterectomy.