Development and validation of a novel deep learning coronary artery plaque quantification model

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: ICC 0.95 for total plaque volume, ICC 0.90 for calcified plaque volume

• Primary Outcome: Correlation between automated and expert plaque volume quantification

• Nnt Or Sensitivity: Pearson's r 0.95 for total plaque, 0.90 for calcified plaque; Spearman's rho 0.87 and 0.93 respectively

• Confidence Interval: 95% limits of agreement: -102 to 85 mm³ for total plaque, -21.97 to 21.42 mm³ for calcified plaque

Clinical Application

Requires integration with existing CCTA workflow and validation in local practice settings Could support CCTA reporting in Australian cardiology and radiology practices, potentially relevant for Medicare item 57360 (CCTA). Would require TGA approval for clinical use and integration with existing PACS systems Patients undergoing CCTA for coronary artery disease assessment, particularly those requiring plaque burden quantification

Abstract

BACKGROUND: Coronary Computed Tomography Angiography (CCTA) is an established tool for assessing coronary artery disease. CCTA determined total coronary artery plaque volume predicts cardiovascular events, but manual quantification is impractical for routine use. Deep learning-based methods offer a promising solution for automated plaque volume assessment. METHODS: We developed and validated a novel software, QuantiPlaque, powered by deep learning models, for automated segmentation of total and calcified coronary plaque volume. Expert manual annotation served as the reference standard. Correlations between deep learning and expert segmentation were evaluated using intraclass correlation coefficient (ICC), Pearson's r, and Spearman's rho, and agreements were evaluated with Bland-Altman analyses. RESULTS: A total of 115 CCTA scans were included. Mean (range) age was 58 (51-64) and 51% were females. The mean coronary artery calcium score was 56 Agatston units, ranging from 0 to 601. The model demonstrated strong correlation and agreement with expert annotation for per-patient total plaque volume (ICC 0.95, mean difference - 8.35 mm3, 95% limit of agreement - 102 to 85 mm3, Spearman's rho 0.87, Pearson's r 0.95) and calcified plaque volume (ICC 0.90, mean difference - 0.28 mm3, 95% limits of agreement - 21.97 to 21.42 mm3, Spearman's rho 0.93, Pearson's r 0.90). Per-vessel analysis showed strong correlation in the left anterior descending artery and right coronary artery but was weaker in the left circumflex artery territory. CONCLUSION: The evaluated deep learning model provides accurate quantification of total and calcified plaque burden, with strong correlation and agreement to expert annotation.

References

1. 1.Malmqvist, J., Jernberg, T., Vedad, R., & Wang, C. (2026). Development and validation of a novel deep learning coronary artery plaque quantification model. BMC Medical Imaging. https://doi.org/10.1007/s00330-025-11410-w