Coronary revascularization: a long-term perspective.

Clinical Snapshot

Key Findings

• Effect Size: Not applicable - qualitative forecasting

• Primary Outcome: Prediction of personalised, AI-guided coronary revascularization by 2040

• Nnt Or Sensitivity: Not applicable - forecasting study without quantitative outcomes

• Confidence Interval: Not provided

Clinical Application

Highly dependent on technology development, regulatory approval, and healthcare system adoption Relevance to Australian practice depends on TGA approval of novel devices, PBS funding decisions, and integration with existing cardiac services infrastructure All patients with coronary artery disease requiring revascularization consideration

Abstract

This paper will forecast advancements in coronary revascularization by 2040, drawing on historical trends and recent breakthroughs. Having forecasted in 2000 the impact of innovations like drug-eluting stents, coronary computed tomography angiography, and bioresorbable scaffolds, the authors examine the evolving landscape of coronary artery disease treatment emphasizing artificial intelligence and omics sciences. Imagenomics-the integration of imaging and omics-will be a transformative tool with artificial intelligence enabling more personalized decisions between pharmacological and mechanical revascularization. The shift towards minimally invasive, image-guided procedures is discussed along with the potential obsolescence of current antiplatelet and anticoagulant therapies with novel biomimetic peptides like CD31-covalently bound to metallic or polymeric devices. Advances in photon-counting computed tomography and Fibre Optic Real Shape promise high-resolution imaging with lower radiation, enhancing procedural safety and diagnostic accuracy. It is anticipated that robotics and 3D holograms in percutaneous and surgical revascularization will improve precision and the resulting outcomes. Additionally, the need for mechanical revascularization for younger patients may decline due to effective plaque regression therapies and novel potent anti-atherogenic biologics. However, the aging population will drive demand for mechanical interventions, with advancements in atherectomy and lithotripsy techniques improving outcomes in complex, calcified lesions. This comprehensive analysis outlines a future where myocardial revascularization becomes increasingly personalized, with technology-driven interventions redefining cardiovascular medicine.

References

1. 1.Serruys, P. W., Oshima, A., Ferraz-Costa, G., Garg, S., Tsai, T. Y., Sharif, F., & Onuma, Y. (2026). Coronary revascularization: a long-term perspective. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaf883