Research AppraisalSystematic Review

Comparative analysis of the improvement in shoulder rotation in complex shoulder fractures treated by reverse shoulder arthroplasty compared to open reduction and internal fixation: a systematic review and meta-analysis

Archives of orthopaedic and trauma surgeryAlbadran, Adeeba, Alsugair, Reem, AlHarthi, Alanood et al.27 May 2026DOI

Clinical Snapshot

75CEBM
Evidence: ModerateSystematic Review

PICO Framework

P — PopulationPatients aged ≥65 years with complex proximal humeral fractures
I — InterventionReverse shoulder arthroplasty (RSA)
C — ComparatorOpen reduction and internal fixation (ORIF)
O — OutcomesShoulder rotation, functional scores (Constant-Murley, Oxford Shoulder Score), complications, reoperation rates

Bottom Line

This large meta-analysis of over 34,000 elderly patients with complex proximal humeral fractures found that reverse shoulder arthroplasty offers modest advantages in forward flexion compared to open reduction and internal fixation, but does not significantly improve overall functional scores or reduce complications. The evidence suggests RSA may be preferred in elderly patients with poor bone quality or rotator cuff pathology, while ORIF remains appropriate when joint preservation is feasible. However, the authors acknowledge that high-quality randomized controlled trials with standardized outcome reporting are still needed to definitively guide surgical decision-making. Clinicians should consider patient-specific factors including bone quality, rotator cuff integrity, and functional demands when choosing between these interventions.

Evidence: Moderate

Key Findings

  • P Value: Non-significant for most outcomes except forward flexion

  • Effect Size: Greater forward flexion with RSA, trend toward improved abduction

  • Primary Outcome: Shoulder rotation and functional outcomes

  • Nnt Or Sensitivity: Not applicable - comparative effectiveness study

  • Confidence Interval: Not reported in abstract

Clinical Application

Both procedures are standard orthopaedic interventions available in major Australian hospitals Relevant to Australian practice; both RSA and ORIF are PBS-funded procedures for appropriate indications; aligns with RACS guidelines for trauma management in elderly Elderly patients (≥65 years) with complex proximal humeral fractures

Abstract

PURPOSE: To compare the clinical and functional outcomes of open reduction and internal fixation (ORIF) and reverse shoulder arthroplasty (RSA) in patients aged ≥ 65 years with complex proximal humeral fractures (PHFs). METHODS: A systematic review and meta-analysis was conducted according to the PRISMA guidelines. PubMed, Web of Science, ScienceDirect, EBSCO, and the Cochrane Library were searched for randomized controlled trials (RCTs) and cohort studies published in English without date restrictions. Eligible studies compared RSA and ORIF in elderly patients with PHFs and reported functional, radiographic, or complication outcomes. Pooled data were analyzed using a random-effects model. RESULTS: Twenty-two studies involving > 34,000 patients were included. RSA was associated with greater forward flexion and a trend toward improved abduction, whereas internal rotation favored ORIF without reaching significance. No significant differences were observed in external rotation. The functional scores (Constant-Murley, Oxford Shoulder Score) were similar, and the complication and reoperation rates did not differ significantly between the groups. CONCLUSION: RSA offers modest advantages in forward flexion compared with ORIF but does not consistently improve overall functional scores or reduce complications. RSA may be preferred in elderly patients with poor bone stock or rotator cuff pathology, whereas ORIF remains appropriate for patients in whom joint preservation is feasible. High-quality RCTs with standardized outcome reporting are needed to clarify the optimal surgical management.

References

  1. 1.Albadran, A., Alsugair, R., AlHarthi, A., Alshangiti, H., Alqahtani, H., Alsugair, G., Ababtain, R., Alhajress, D., Alotaibi, E., Aldokhail, L., & Alshehri, K. (2026). Comparative analysis of the improvement in shoulder rotation in complex shoulder fractures treated by reverse shoulder arthroplasty compared to open reduction and internal fixation: a systematic review and meta-analysis. Archives of Orthopaedic and Trauma Surgery. https://doi.org/10.3390/jcm10050979
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