Biwt-UNet: lung nodule segmentation via wavelet transform and multi-scale feature fusion

Clinical Snapshot

Key Findings

• P Value: Not reported

• Effect Size: Dice coefficient: 90.18%, IoU: 82.67%, normalized surface dice: 96.39%

• Primary Outcome: Lung nodule segmentation accuracy measured by Dice similarity coefficient

• Nnt Or Sensitivity: Sensitivity/specificity not reported; performance represents substantial improvement over state-of-the-art methods

• Confidence Interval: Not reported

Clinical Application

Requires integration into existing PACS systems and radiologist workflow validation Relevant to Australian lung cancer screening programs and could support TGA-approved CAD systems; aligns with RACGP lung cancer screening guidelines Patients undergoing CT screening for lung cancer or nodule evaluation

Abstract

Lung nodule segmentation is a crucial step in computer-aided diagnosis of lung diseases and is of great significance for early detection and diagnosis of lung cancer. Traditional segmentation methods face many challenges, such as blurred nodule boundaries that are difficult to distinguish effectively, and the diversity of nodule sizes and shapes, which together increases the difficulty of segmenting lung nodules. Existing approaches often fail to address these issues adequately, highlighting the need for more effective solutions. To meet these challenges, this paper proposes a hybrid lung nodule segmentation approach-Biwt-UNet that integrates improved Haar wavelet transform and multi-scale feature information from the multi-scale fusion module and bi-encoder fusion module proposed in this study. The approach enables accurate segmentation of lung nodules of varying sizes, diverse shapes and, in particular, indistinct boundaries. Experimental results on the public LIDC-IDRI dataset demonstrate that Biwt-UNet achieves excellent segmentation performance. It significantly surpasses other state-of-the-art methods with an average dice similarity coefficient of 90.18%, an average intersection over union of 82.67%, and an average normalized surface dice of 96.39%, fully validating the effectiveness and accuracy of the proposed model in CT-based lung nodule analysis. Moreover, ablation studies further confirm the individual contributions of each architectural component and show that the best performance is achieved within an acceptable parameter budget. This study provides a new technical perspective for automatic lung nodule segmentation and is expected to assist physicians in more efficient diagnosis.

References

1. 1.Zhang, H., Huang, X., Zhao, Y., Zhang, Z., & Sun, G. (2026). Biwt-UNet: lung nodule segmentation via wavelet transform and multi-scale feature fusion. Biomedical Physics & Engineering Express. https://doi.org/10.1088/2057-1976/ae6cff