Attention-based deep learning network for predicting World Health Organization meningioma grade and Ki-67 expression based on magnetic resonance imaging

Clinical Snapshot

Key Findings

• P Value: p < 0.001 vs clinical models, p < 0.001-0.002 vs radiomics models

• Effect Size: AUC 0.90 for WHO grading, AUC 0.89 for Ki-67 expression

• Primary Outcome: Diagnostic accuracy for WHO meningioma grading and Ki-67 expression prediction

• Nnt Or Sensitivity: Sensitivity and specificity not reported; Dice coefficients 0.98 for brain, 0.87 for tumour segmentation

• Confidence Interval: WHO grading: 0.85-0.93; Ki-67 expression: 0.85-0.93

Clinical Application

Requires advanced computational infrastructure and technical expertise; needs local validation before clinical deployment Could support neurosurgical planning in Australian centres with appropriate imaging informatics infrastructure; aligns with RANZCR imaging guidelines for brain tumour assessment Patients with suspected meningiomas requiring preoperative WHO grading and proliferation index assessment

Abstract

OBJECTIVES: Preoperative assessment of World Health Organization (WHO) meningioma grading and Ki-67 expression is crucial for treatment strategies. We aimed to develop a fully automated attention-based deep learning network to predict WHO meningioma grading and Ki-67 expression. MATERIALS AND METHODS: This retrospective study included 952 meningioma patients, divided into training (n = 542), internal validation (n = 96), and external test sets (n = 314). For each task, clinical, radiomics, and deep learning models were compared. We used no-new-Unet (nn-Unet) models to construct the segmentation network, followed by four classification models using ResNet50 or Swin Transformer architectures with 2D or 2.5D input strategies. All deep learning models incorporated attention mechanisms. RESULTS: Both the segmentation and 2.5D classification models demonstrated robust performance on the external test set. The segmentation network achieved Dice coefficients of 0.98 (0.97-0.99) and 0.87 (0.83-0.91) for brain parenchyma and tumour segmentation. For predicting meningioma grade, the 2.5D ResNet50 achieved the highest area under the curve (AUC) of 0.90 (0.85-0.93), significantly outperforming the clinical (AUC = 0.77 [0.70-0.83], p < 0.001) and radiomics models (AUC = 0.80 [0.75-0.85], p < 0.001). For Ki-67 expression prediction, the 2.5D Swin Transformer achieved the highest AUC of 0.89 (0.85-0.93), outperforming both the clinical (AUC = 0.76 [0.71-0.81], p < 0.001) and radiomics models (AUC = 0.82 [0.77-0.86], p = 0.002). CONCLUSION: Our automated deep learning network demonstrated superior performance. This novel network could support more precise treatment planning for meningioma patients. KEY POINTS: Question Can artificial intelligence accurately assess meningioma WHO grade and Ki-67 expression from preoperative MRI to guide personalised treatment and follow-up strategies? Findings The attention-enhanced nn-Unet segmentation achieved high accuracy, while 2.5D deep learning models with attention mechanisms achieved accurate prediction of grades and Ki-67. Clinical relevance Our fully automated 2.5D deep learning model, enhanced with attention mechanisms, accurately predicts WHO grades and Ki-67 expression levels in meningiomas, offering a robust, objective, and non-invasive solution to support clinical diagnosis and optimise treatment planning.

References

1. 1.Cheng, X., Li, H., Li, C., Li, J., Liu, Z., Fan, X., Lu, C., Song, K., Shen, Z., Wang, Z., Yang, Q., Zhang, J., Yin, J., Qian, C., You, Y., & Wang, X. (2026). Attention-based deep learning network for predicting World Health Organization meningioma grade and Ki-67 expression based on magnetic resonance imaging. European Radiology. https://doi.org/10.1093/neuonc/noaa177