Artificial Intelligence in Physical, Occupational and Neuro-Rehabilitation: Clinical Effectiveness, Prognostic Performance, and Pre-Implementation Feasibility - A Systematic Review

Clinical Snapshot

Key Findings

• P Value: Not reported for pooled analysis

• Effect Size: Modest clinical effects with signals of benefit in selected musculoskeletal and telerehabilitation contexts

• Primary Outcome: Clinical effectiveness comparable to conventional rehabilitation with modest, heterogeneous effects

• Nnt Or Sensitivity: Prognostic models showed encouraging discrimination in development settings but lacked external validation

• Confidence Interval: Not reported due to heterogeneity

Clinical Application

Implementation challenges include training gaps, governance issues, IT support requirements, costs, and digital equity concerns Relevant to Australian telehealth initiatives and rural rehabilitation access, but requires consideration of PBS funding models and TGA device regulation for AI-enabled interventions Patients requiring physical, occupational, or neurological rehabilitation across diverse conditions

Abstract

BACKGROUND: Global rehabilitation needs far exceed capacity, and artificial intelligence (AI) is proposed to extend access, personalise therapy, and support adherence. We aimed to synthesise evidence on clinical effectiveness, prognostic performance, and implementation feasibility of AI-enabled rehabilitation across conditions and care settings. METHODS: We conducted a mixed-methods systematic review of AI-enabled rehabilitation and rehabilitation-led prevention relevant to physiotherapy practice. MEDLINE, Embase, Web of Science, CINAHL, Scopus, and IEEE Xplore were searched. Methodological quality was appraised with MMAT and PROBAST + AI (prediction/diagnostic models), with a priori AI-reporting minimums checklist. Given heterogeneity, evidence was integrated via prespecified thematic synthesis. FINDINGS: Thirty studies from diverse regions met inclusion, comprising randomised trials, non-randomised comparisons, cohorts, surveys, qualitative work, and prediction/diagnostic models. Clinical effects were modest and heterogeneous. Most AI-enabled interventions were comparable to conventional rehabilitation; signals of benefit appeared in selected musculoskeletal and telerehabilitation contexts but rarely persisted beyond short follow-up. Internal validity was frequently limited by asymmetric adherence measurement objective telemetry in AI arms versus self-report or attendance in controls alongside low uptake and declining engagement over time. Safety and usability were generally favourable within short horizons, although surveillance and explicit attribution to AI components were inconsistently reported. Prognostic and adaptive models showed encouraging discrimination in development settings but lacked multicentre external validation, calibration, subgroup-error profiling, and prospective impact evaluation, leaving them unready for clinical use. Stakeholders reported willingness to adopt AI while highlighting gaps in training, governance and information technology support, costs, and digital equity. Overall certainty for comparative clinical outcomes was low to moderate, for models, very low. CONCLUSION: AI in rehabilitation presently acts more as a behavioural amplifier structuring home programmes and supporting execution than as a replacement for dose-matched therapist-delivered care. Credible scale-up should position AI as an adjunct and hinge on arm-symmetric capture of adherence and execution, clinically meaningful outcomes paired with verified behaviour change over treatment and longer-term follow-up, and model deployment only after transparent development, external validation with calibration and subgroup-error characterisation, and demonstration of clinical impact. Embedding equity and economic evaluation, together with living oversight and version control, will be essential to convert promising prototypes into trustworthy, durable, and widely accessible services.

References

1. 1.El Arab, R. A., Al Moosa, O. A., Almagharbeh, W. T., Abuadas, F., Abdalla, N., Abdrbo, A., & Hassanein, S. (2026). Artificial Intelligence in Physical, Occupational and Neuro-Rehabilitation: Clinical Effectiveness, Prognostic Performance, and Pre-Implementation Feasibility - A Systematic Review. Journal of Medical Systems. https://doi.org/10.1080/21642850.2025.2493139