Research Appraisalother

Artificial intelligence enables scale, consistency, and rigor in forensic identity inference.

Croatian medical journalBudowle, Bruce, Newman, Stephen, Jones, Nicole et al.15 June 2026

Clinical Snapshot

30CEBM
Evidence: Weakother

PICO Framework

P — PopulationForensic DNA analysis cases requiring identity inference from genetic, genealogical, and contextual information
I — InterventionArtificial intelligence-enabled computational decision-support systems for forensic identity inference
C — ComparatorCurrent human-centered manual reasoning workflows in forensic DNA analysis
O — OutcomesScale, consistency, rigor, transparency, reproducibility, and documentation of forensic identity inference processes

Bottom Line

This narrative review proposes using computational decision-support systems to enhance forensic DNA analysis workflows, particularly for genetic genealogy cases. While the authors identify legitimate challenges in current manual processes - including scalability, consistency, and documentation issues - the paper lacks empirical evidence supporting the proposed solutions. The conceptual framework may have merit, but implementation would require extensive validation studies, regulatory approval, and consideration of ethical implications. Australian forensic laboratories would need to evaluate such systems against existing standards and privacy requirements. The commercial affiliation of the lead author raises questions about potential bias. Clinicians should view this as an early-stage technological proposal requiring substantial further research rather than an evidence-based recommendation for practice change.

Evidence: Weak

Key Findings

  • Effect Size: Not applicable - no quantitative analysis

  • Primary Outcome: Conceptual framework for AI-enabled forensic identity inference systems

  • Nnt Or Sensitivity: Not applicable - conceptual review only

  • Confidence Interval: Not provided

Clinical Application

Requires significant technological infrastructure and validation studies before implementation Would need alignment with Australian forensic standards, privacy laws, and validation by National Institute of Forensic Science (NIFS). Implementation would require coordination with state police forensic services and consideration of Australian privacy legislation. Forensic laboratories conducting DNA analysis and genetic genealogy investigations

Abstract

Advances in forensic genomics, which include massively parallel sequencing, dense single nucleotide polymorphism testing, and forensic genetic genealogy (FGG), have greatly expanded the range of cases in which DNA evidence can generate investigative leads. As a result, the primary limitations in modern forensic DNA analysis are no longer analytical sensitivity or marker availability, but the ability to reason consistently, transparently, and at scale over increasingly complex genetic, genealogical, and contextual information. Current forensic workflows remain predominantly human-centered, relying on manual reasoning that is difficult to standardize, reproduce, document, or scale across growing case inventories. The potential of artificial intelligence (AI) is described as an enabling layer for forensic identity inference, defined here as computational decision-support systems that structure, prioritize, and document reasoning over genetic associations, genealogical structures, and investigative context during identity hypothesis development. While formal statistical inference quantifies evidentiary weight, identity inference governs how evidence is explored, combined, and acted upon during investigations. AI-assisted systems can augment, but not replace, expert judgment by supporting scalable prioritization, relational reasoning, and systematic documentation of analytical decisions, while reducing bias. Properly designed AI-enabled systems offer a path to sustainably scaling FGG while supporting scientific rigor, accountability, and public trust.

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