Health Technology/clinical-trials

Withdrawn Trial Spotlight: AI-Driven ROTEM Interpretation vs Expert Panel Consensus in Cardiac and Liver Transplant Coagulopathy — Clinical Implications for Perioperative Practice

247 Health News Editorial

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18 July 2026

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4 min read

·clinical-trials

A now-withdrawn Turkish clinical trial sought to determine whether large language model AI tools — ChatGPT and Gemini — could match expert clinician interpretation of ROTEM coagulation data in cardiac surgery and liver transplantation. Though no data were collected, the trial raises important questions about AI decision-support in perioperative haemostasis that remain highly relevant to anaesthetists, intensivists, and haematologists worldwide.

Originally reported by ClinicalTrials.gov

References

  1. 1.Ondokuz Mayıs University. (2025). Assessment of artificial intelligence algorithms for ROTEM analysis in coagulation management (NCT07043556). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07043556
  2. 2.Afshari, A., Wikkelso, A., Brok, J., Moller, A. M., & Wetterslev, J. (2011). Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding. Cochrane Database of Systematic Reviews, 2011(3), CD007871. https://doi.org/10.1002/14651858.CD007871.pub2
  3. 3.Meybohm, P., Herrmann, E., Steinbicker, A. U., Wittmann, M., Gruenewald, M., Fischer, D., Baumgarten, G., Renner, J., Papadopoulos, D., Weber, C. F., Zacharowski, K., & QUIPS Investigators. (2017). Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient's outcome: A prospective, multicenter cohort study with a noninferiority design. Annals of Surgery, 265(2), 203–211. https://doi.org/10.1097/SLA.0000000000001747
  4. 4.Clevenger, B., Mallett, S. V., Klein, A. A., & Richards, T. (2015). Patient blood management to reduce surgical risk. British Journal of Surgery, 102(11), 1325–1337. https://doi.org/10.1002/bjs.9898
  5. 5.Raphael, J., Mazer, C. D., Subramani, S., Schroeder, A., Abdalla, M., Ferreira, R., Roman, P. E., Patel, N., Welsby, I., Greilich, P. E., Harvey, R., Ranucci, M., & Heller, L. B. (2019). Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients. Journal of Cardiothoracic and Vascular Anesthesia, 33(11), 2887–2899. https://doi.org/10.1053/j.jvca.2019.04.003
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