Withdrawn Trial Spotlight: AI-Driven ROTEM Interpretation vs Expert Panel Consensus in Cardiac and Liver Transplant Coagulopathy — Clinical Implications for Perioperative Practice
247 Health News Editorial
·18 July 2026
·4 min read
·clinical-trialsA now-withdrawn Turkish clinical trial sought to determine whether large language model AI tools — ChatGPT and Gemini — could match expert clinician interpretation of ROTEM coagulation data in cardiac surgery and liver transplantation. Though no data were collected, the trial raises important questions about AI decision-support in perioperative haemostasis that remain highly relevant to anaesthetists, intensivists, and haematologists worldwide.
Originally reported by ClinicalTrials.gov
References
- 1.Ondokuz Mayıs University. (2025). Assessment of artificial intelligence algorithms for ROTEM analysis in coagulation management (NCT07043556). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07043556
- 2.Afshari, A., Wikkelso, A., Brok, J., Moller, A. M., & Wetterslev, J. (2011). Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding. Cochrane Database of Systematic Reviews, 2011(3), CD007871. https://doi.org/10.1002/14651858.CD007871.pub2
- 3.Meybohm, P., Herrmann, E., Steinbicker, A. U., Wittmann, M., Gruenewald, M., Fischer, D., Baumgarten, G., Renner, J., Papadopoulos, D., Weber, C. F., Zacharowski, K., & QUIPS Investigators. (2017). Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient's outcome: A prospective, multicenter cohort study with a noninferiority design. Annals of Surgery, 265(2), 203–211. https://doi.org/10.1097/SLA.0000000000001747
- 4.Clevenger, B., Mallett, S. V., Klein, A. A., & Richards, T. (2015). Patient blood management to reduce surgical risk. British Journal of Surgery, 102(11), 1325–1337. https://doi.org/10.1002/bjs.9898
- 5.Raphael, J., Mazer, C. D., Subramani, S., Schroeder, A., Abdalla, M., Ferreira, R., Roman, P. E., Patel, N., Welsby, I., Greilich, P. E., Harvey, R., Ranucci, M., & Heller, L. B. (2019). Society of Cardiovascular Anesthesiologists Clinical Practice Improvement Advisory for management of perioperative bleeding and hemostasis in cardiac surgery patients. Journal of Cardiothoracic and Vascular Anesthesia, 33(11), 2887–2899. https://doi.org/10.1053/j.jvca.2019.04.003
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247 Health News Editorial
247 Health News is a medical intelligence platform delivering evidence-based research appraisals, clinical trial monitoring, and health technology news for healthcare professionals.
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