Health Technology/clinical-trials

Wearable ECG-PPG Synchronisation Trial Opens: Can the CardioWatch Reconstruct QT/QTc From Photoplethysmography Alone?

247 Health News Editorial

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23 July 2026

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5 min read

·clinical-trials

A new observational study by Corsano Health B.V. will collect synchronised PPG and ECG recordings from 50 healthy volunteers to build a reference dataset for reconstructing QT/QTc intervals from wrist-worn wearable signals. If successful, the resulting algorithms could transform continuous cardiac safety monitoring across clinical and community settings. The trial is not yet recruiting; estimated completion is September 2026.

Originally reported by ClinicalTrials.gov

References

  1. 1.Corsano Health B.V. (2025). Collection of synchronised ECG and PPG recordings in healthy adult volunteers to develop and evaluate AI methods for ECG-parameter reconstruction from PPG (Focus: QT/QTc) [Clinical trial registration NCT07684807]. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07684807
  2. 2.Goldenberg, I., Moss, A. J., & Zareba, W. (2006). QT interval: How to measure it and what is 'normal'. Journal of Cardiovascular Electrophysiology, 17(3), 333–336. https://doi.org/10.1111/j.1540-8167.2006.00408.x
  3. 3.Elgendi, M., Norton, I., Brearley, M., Abbott, D., & Schuurmans, D. (2013). Systolic peak detection in acceleration photoplethysmograms measured from emergency responders in tropical conditions. PLOS ONE, 8(10), e76585. https://doi.org/10.1371/journal.pone.0076585
  4. 4.International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. (2005). ICH E14 guideline: The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. ICH. https://www.ich.org/page/efficacy-guidelines
  5. 5.Charlton, P. H., Kyriacou, P. A., Mant, J., & Alastruey, J. (2020). Acquiring wearable photoplethysmography data in daily life: The PPG diary pilot study. Engineering Proceedings, 2(1), 19. https://doi.org/10.3390/engproc2020002019
  6. 6.Verrier, R. L., Klingenheben, T., Malik, M., El-Sherif, N., Exner, D. V., Hohnloser, S. H., Ikeda, T., Martinez, J. P., Narayan, S. M., Nieminen, T., & Rosenbaum, D. S. (2011). Microvolt T-wave alternans: Physiological basis, methods of measurement, and clinical utility — consensus guideline by the International Society for Holter and Noninvasive Electrocardiology. Journal of the American College of Cardiology, 58(13), 1309–1324. https://doi.org/10.1016/j.jacc.2011.06.029
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