Wearable Continuous Lactate Monitoring vs. Arterial/Venous Sampling in CABG and Valve Surgery: A Single-Centre Validation Study Clinicians Should Watch
247 Health News Editorial
·12 July 2026
·5 min read
·clinical-trialsA Queen Mary University of London study at Barts Hospital is validating a wearable continuous interstitial lactate sensor against arterial and venous blood gas measurements in patients undergoing elective CABG and valve surgery. With 61 participants enrolled and results expected in 2026, this device validation trial could pave the way for non-invasive, real-time lactate monitoring in perioperative and critical care settings.
Originally reported by ClinicalTrials.gov
References
- 1.Queen Mary University of London. (2024). A single centre study comparing continuous interstitial fluid lactate detection (as measured by change in current) to standard measurements of change in venous and arterial lactate in patients undergoing elective coronary artery bypass graft surgery and/or valve replacement (NCT06602336). ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT06602336
- 2.Ranucci, M., De Toffol, B., Isgro, G., Romitti, F., Conti, D., & Vicentini, M. (2006). Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome. Critical Care, 10(6), R167. https://doi.org/10.1186/cc4818
- 3.Bland, J. M., & Altman, D. G. (1986). Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet, 327(8476), 307–310. https://doi.org/10.1016/S0140-6736(86)90837-8
- 4.Nichol, A. D., Egi, M., Pettila, V., Bellomo, R., French, C., Hart, G., Davies, A., Stachowski, E., Reade, M. C., Bailey, M., & Cooper, D. J. (2010). Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study. Critical Care, 14(1), R25. https://doi.org/10.1186/cc8888
- 5.Jansen, T. C., van Bommel, J., Schoonderbeek, F. J., Sleeswijk Visser, S. J., van der Klooster, J. M., Lima, A. P., Willemsen, S. P., & Bakker, J. (2010). Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. American Journal of Respiratory and Critical Care Medicine, 182(6), 752–761. https://doi.org/10.1164/rccm.200912-1918OC
- 6.Andreasen, J. J., Dethlefsen, C., Modrau, I. S., Baech, J., Partly, A., & Siostrzonek, P. (2011). Storage time of autologous pericardial blood influences the quality of blood cardioplegia and early postoperative outcome after coronary artery bypass surgery. European Journal of Cardio-Thoracic Surgery, 40(2), 324–329. https://doi.org/10.1016/j.ejcts.2010.11.028
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247 Health News Editorial
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